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189954-96-9,MFCD09837800
Catalog No.:AA002E3N

189954-96-9 | Firocoxib

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10mg
≥98%
in stock  
$63.00   $44.00
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50mg
≥98%
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$276.00   $193.00
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100mg
≥98%
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$519.00   $363.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002E3N
Chemical Name:
Firocoxib
CAS Number:
189954-96-9
Molecular Formula:
C17H20O5S
Molecular Weight:
336.4027
MDL Number:
MFCD09837800
SMILES:
O=C1OC(C(=C1OCC1CC1)c1ccc(cc1)S(=O)(=O)C)(C)C
NSC Number:
758895
Properties
Computed Properties
 
Complexity:
614  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
2.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:SEQUENTSCIENT-WO2018/109781,2018,A1Locationinpatent:Page/Pagecolumn24

[2]CurrentPatentAssignee:CHINAPHARMACEUTICALUNIVERSITY-CN105859664,2016,ALocationinpatent:Paragraph0019;0020

[3]Leblanc;Roy;Boyce;Brideau;Chan;Charleson;Gordon;Grimm;Guay;Leger;Li;Riendeau;Visco;Wang;Webb;Xu;Prasit[BioorganicandMedicinalChemistryLetters,1999,vol.9,#15,p.2207-2212]

[4]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-CN109810031,2019,ALocationinpatent:Paragraph0061;0062;0063;0064;0065;0066

CASUnavailable 
  189954-96-9 

[1]Leblanc;Roy;Boyce;Brideau;Chan;Charleson;Gordon;Grimm;Guay;Leger;Li;Riendeau;Visco;Wang;Webb;Xu;Prasit[BioorganicandMedicinalChemistryLetters,1999,vol.9,#15,p.2207-2212]

53207-58-2   
3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one 

[1]BioorganicandMedicinalChemistryLetters,1999,vol.9,p.2207-2212

[2]Patent:CN105859664,2016,A

[3]Patent:WO2018/109781,2018,A1

[4]Patent:WO2018/188763,2018,A1

[1]Leblanc;Roy;Boyce;Brideau;Chan;Charleson;Gordon;Grimm;Guay;Leger;Li;Riendeau;Visco;Wang;Webb;Xu;Prasit[BioorganicandMedicinalChemistryLetters,1999,vol.9,#15,p.2207-2212]

[2]CurrentPatentAssignee:FINANZIARIAIMMOBILIAREDIPARTECIPAZIONIECOSTRUZIONISPAABBREVIABILEINFIMP-WO2018/188763,2018,A1

246869-08-9   
3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one 

[1]Leblanc;Roy;Boyce;Brideau;Chan;Charleson;Gordon;Grimm;Guay;Leger;Li;Riendeau;Visco;Wang;Webb;Xu;Prasit[BioorganicandMedicinalChemistryLetters,1999,vol.9,#15,p.2207-2212]

[2]CurrentPatentAssignee:JIANGSUJUNRUOMEDICINE;NANJINGJUNRUOBIOMEDICINERESINSTITUTE-CN110105314,2019,A

Literature

Title: Efficacy and safety of firocoxib for the treatment of pain associated with soft tissue surgery in dogs under field conditions in Japan.

Journal: The Journal of veterinary medical science 20121001

Title: Determination of non-steroidal anti-inflammatory drugs and their metabolites in milk by liquid chromatography-tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20120701

Title: Evaluation of oral administration of firocoxib for the management of musculoskeletal pain and lameness associated with osteoarthritis in horses.

Journal: American journal of veterinary research 20120501

Title: Vesiculobullous skin reaction temporally related to firocoxib treatment in a white rhinoceros (Ceratotherium simum).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20120301

Title: Efficacy of ABT-116, an antagonist of transient receptor potential vanilloid type 1, in providing analgesia for dogs with chemically induced synovitis.

Journal: American journal of veterinary research 20120101

Title: Canine malignant mammary gland neoplasms with advanced clinical staging treated with carboplatin and cyclooxygenase inhibitors.

Journal: In vivo (Athens, Greece) 20120101

Title: Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20110910

Title: Long-term efficacy and safety of firocoxib in the treatment of dogs with osteoarthritis.

Journal: The Veterinary record 20110611

Title: Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy.

Journal: Veterinary anaesthesia and analgesia 20110501

Title: Tolerance of firocoxib in dogs with osteoarthritis during 90 days.

Journal: Journal of veterinary pharmacology and therapeutics 20110401

Title: Determination of firocoxib in equine plasma using high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115

Title: Distribution of flunixin meglumine and firocoxib into aqueous humor of horses.

Journal: Journal of veterinary internal medicine 20110101

Title: [New drugs for horses and production animals in 2010].

Journal: Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere 20110101

Title: Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.

Journal: Protoplasma 20101001

Title: Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.

Journal: American journal of veterinary research 20100901

Title: Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs.

Journal: American journal of veterinary research 20091001

Title: The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial.

Journal: Journal of veterinary science 20090901

Title: The effects of firocoxib (Previcox) in geriatric dogs over a period of 90 days.

Journal: Journal of the South African Veterinary Association 20090901

Title: Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum.

Journal: American journal of veterinary research 20090801

Title: Systematic review of the management of canine osteoarthritis.

Journal: The Veterinary record 20090404

Title: The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses.

Journal: Equine veterinary journal 20090301

Title: Confirmatory analysis of firocoxib in bovine milk by rapid resolution liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215

Title: Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model.

Journal: Journal of veterinary internal medicine 20090101

Title: Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses.

Journal: American journal of veterinary research 20081101

Title: Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs.

Journal: American journal of veterinary research 20080901

Title: Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs.

Journal: Research in veterinary science 20080201

Title: Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis.

Journal: Journal of the American Veterinary Medical Association 20080101

Title: Quantitative HPLC-UV method for the determination of firocoxib from horse and dog plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

Title: Automated liquid chromatography-tandem mass spectrometry method for the analysis of firocoxib in urine and plasma from horse and dog.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Pharmacokinetics and metabolism of orally administered firocoxib, a novel second generation coxib, in horses.

Journal: Journal of veterinary pharmacology and therapeutics 20070601

Title: Evaluation of the adverse effects of oral firocoxib in healthy dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20070601

Title: [European symposium about osteoarthritis in a dog].

Journal: Tijdschrift voor diergeneeskunde 20070101

Title: Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Switching NSAIDs in practice: insights from the Previcox (firocoxib) Experience Trial.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20070101

Title: Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis.

Journal: The Veterinary record 20061021

Title: The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors.

Journal: The Veterinary clinics of North America. Small animal practice 20060901

Title: Clinical effectiveness and safety of a new NSAID, firocoxib: a 1,000 dog study.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20060101

Title: Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20060101

Title: In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia.

Journal: American journal of veterinary research 20050701

Title: In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis.

Journal: American journal of veterinary research 20040401

Title: Steagall PV, et al. Evaluation of the adverse effects of oral firocoxib in healthy dogs. J Vet Pharmacol Ther. 2007 Jun;30(3):218-23.

Title: Stock ML, et al. Pharmacokinetics of firocoxib in preweaned calves after oral and intravenous administration. J Vet Pharmacol Ther. 2014 Oct;37(5):457-63.

Title: Albanese F, et al. Clinical outcome and cyclo-oxygenase-2 expression in five dogs with solar dermatitis/actinic keratosis treated with firocoxib. Vet Dermatol. 2013 Dec;24(6):606-12, e147.

Title: McCann ME, et al. In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia. Am J Vet Res. 2005 Jul;66(7):1278-84.

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