Home Amines 190277-13-5
190277-13-5,MFCD00672678
Catalog No.:AA002ED9

190277-13-5 | Carbamic acid, N-[3-[2-(acetylamino)ethyl]-1H-indol-5-yl]-, methyl ester

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1mg
≥95%
in stock  
$58.00   $40.00
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5mg
≥95%
in stock  
$258.00   $180.00
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10mg
98%
in stock  
$361.00   $253.00
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50mg
98%
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$1,379.00   $965.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002ED9
Chemical Name:
Carbamic acid, N-[3-[2-(acetylamino)ethyl]-1H-indol-5-yl]-, methyl ester
CAS Number:
190277-13-5
Molecular Formula:
C14H17N3O3
Molecular Weight:
275.3031
MDL Number:
MFCD00672678
SMILES:
COC(=O)Nc1ccc2c(c1)c(CCNC(=O)C)c[nH]2
Properties
Computed Properties
 
Complexity:
362  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
0.4  

Literature

Title: Involvement of carbonic anhydrases in the ocular hypotensive effect of melatonin analogue 5-MCA-NAT.

Journal: Journal of pineal research 20120401

Title: Regulation of ocular adrenoceptor genes expression by 5-MCA-NAT: implications for glaucoma treatment.

Journal: Pharmacogenetics and genomics 20110901

Title: Design of novel melatonin analogs for the reduction of intraocular pressure in normotensive rabbits.

Journal: The Journal of pharmacology and experimental therapeutics 20110601

Title: Design and synthesis of naphthalenic derivatives as new ligands at the melatonin binding site MT3.

Journal: European journal of medicinal chemistry 20110501

Title: The use of mucoadhesive polymers to enhance the hypotensive effect of a melatonin analogue, 5-MCA-NAT, in rabbit eyes.

Journal: Investigative ophthalmology & visual science 20110318

Title: Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.

Journal: British journal of pharmacology 20110301

Title: MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries.

Journal: The Journal of pharmacology and experimental therapeutics 20110101

Title: Molecular and cellular pharmacological properties of 5-methoxycarbonylamino-N-acetyltryptamine (MCA-NAT): a nonspecific MT3 ligand.

Journal: Journal of pineal research 20100401

Title: An unexpected effect of 5-MCA-NAT in chick retinal development.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20091001

Title: 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit.

Journal: Journal of pineal research 20090901

Title: Ophthalmic formulations of the intraocular hypotensive melatonin agent 5-MCA-NAT.

Journal: Experimental eye research 20090301

Title: A novel quantitative structure-activity relationship method to predict the affinities of MT3 melatonin binding site.

Journal: European journal of medicinal chemistry 20081201

Title: Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3.

Journal: Bioorganic & medicinal chemistry 20080501

Title: Requirement of intact sympathetic transmission for the ocular hypotensive effects of melatonin and 5-MCA-NAT.

Journal: Autonomic neuroscience : basic & clinical 20071230

Title: Cellular mechanisms involved in the melatonin inhibition of HT-29 human colon cancer cell proliferation in culture.

Journal: Journal of pineal research 20070901

Title: Mechanisms of N-methyl-D-aspartate receptor inhibition by melatonin in the rat striatum.

Journal: Journal of neuroendocrinology 20041101

Title: Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes.

Journal: Journal of glaucoma 20041001

Title: Melatonin inhibits nitrate tolerance in isolated coronary arteries.

Journal: British journal of pharmacology 20030801

Title: Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor.

Journal: British journal of pharmacology 20030301

Title: Melatonin receptors in rat hippocampus: molecular and functional investigations.

Journal: Hippocampus 20020101

Title: Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation.

Journal: European journal of pharmacology 20011102

Title: Expression and functional characterization of the mt1 melatonin receptor from rat brain in Xenopus oocytes: evidence for coupling to the phosphoinositol pathway.

Journal: Journal of pineal research 20010401

Title: Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbits.

Journal: European journal of pharmacology 20010330

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Tags:190277-13-5 Molecular Formula|190277-13-5 MDL|190277-13-5 SMILES|190277-13-5 Carbamic acid, N-[3-[2-(acetylamino)ethyl]-1H-indol-5-yl]-, methyl ester