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190791-29-8,MFCD13185249
Catalog No.:AA002ER0

190791-29-8 | Lasofoxifene hcl

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$70.00   $49.00
- +
10mg
≥98%
in stock  
$132.00   $92.00
- +
25mg
≥98%
in stock  
$309.00   $216.00
- +
50mg
≥98%
in stock  
$543.00   $380.00
- +
100mg
98%
in stock  
$1,061.00   $743.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002ER0
Chemical Name:
Lasofoxifene hcl
CAS Number:
190791-29-8
Molecular Formula:
C32H37NO8
Molecular Weight:
563.6381
MDL Number:
MFCD13185249
SMILES:
OC(=O)[C@H]([C@@H](C(=O)O)O)O.Oc1ccc2c(c1)CC[C@@H]([C@@H]2c1ccc(cc1)OCCN1CCCC1)c1ccccc1
Properties
Computed Properties
 
Complexity:
667  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
9  

Literature

Title: Andersson A, et al. Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced arthritis. Rheumatology (Oxford). 2016 Mar;55(3):553-63.

Title: Andreano KJ, et al. The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor. Mol Cancer Ther. 2020 Jul. 19(7):1395-1405.

Title: Lainé M, et al. Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer. Breast Cancer Res. 2021 May 12. 23(1):54.

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SDS
Tags:190791-29-8 Molecular Formula|190791-29-8 MDL|190791-29-8 SMILES|190791-29-8 Lasofoxifene hcl