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191219-80-4,MFCD04113219
Catalog No.:AA002F26

191219-80-4 | Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$16.00   $11.00
- +
5mg
97%
in stock  
$41.00   $29.00
- +
10mg
97%
in stock  
$61.00   $43.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002F26
Chemical Name:
Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-
CAS Number:
191219-80-4
Molecular Formula:
C17H16ClN3O
Molecular Weight:
313.7814
MDL Number:
MFCD04113219
SMILES:
CCc1ccc2c(n1)n(CC)c(=O)nc2c1cccc(c1)Cl
Properties
Computed Properties
 
Complexity:
453  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
4  

Downstream Synthesis Route
191219-80-4    34241-39-9   
7-(1-bromoethyl)-4-(3-chlorophenyl)-1-ethylpyrido2,3-dpyrimidin-2(1H)-one 
 
4-(3-chlorophenyl)-7-cyclopropyl-1-ethylpyrido2,3-dpyrimidin-2(1H)-one 

[1]CurrentPatentAssignee:ASTELLASPHARMAINC.-US6136810,2000,A

191219-80-4    34241-39-9   
7-(1-acetoxyethyl)-4-(3-chlorophenyl)-1-ethylpyrido2,3-dpyrimidin-2(1H)-one 

[1]CurrentPatentAssignee:ASTELLASPHARMAINC.-US6136810,2000,A

Literature

Title: Effect of phosphodiesterase antagonists on glucocorticoid mediated growth inhibition in murine skin cell lines.

Journal: European journal of pharmacology 20090521

Title: The type 4 phosphodiesterase inhibitors rolipram and YM976 facilitate recall of the weak version of the passive avoidance task in the day-old chick.

Journal: Pharmacology, biochemistry, and behavior 20090401

Title: [Effects of phosphodiesterase-4 inhibitor on the mucin secretion in airway stimulated with acrolein: experiment with rats].

Journal: Zhonghua yi xue za zhi 20081118

Title: The effects of a novel phosphodiesterase 7A and -4 dual inhibitor, YM-393059, on T-cell-related cytokine production in vitro and in vivo.

Journal: European journal of pharmacology 20060710

Title: Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle.

Journal: European journal of pharmacology 20030530

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Antiasthmatic effect of YM976, a novel PDE4 inhibitor, in guinea pigs.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity.

Journal: The Journal of pharmacology and experimental therapeutics 20001001

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Tags:191219-80-4 Molecular Formula|191219-80-4 MDL|191219-80-4 SMILES|191219-80-4 Pyrido[2,3-d]pyrimidin-2(1H)-one, 4-(3-chlorophenyl)-1,7-diethyl-