Catalog No.:AA01EO5T

1912445-55-6 | BMS-986195

Name: Name:BMS-986195
Brand: AABLOCKS
SKU: AA01EO5T
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

5mg

98%

in stock

$33.00 $23.00

- +

25mg

98%

in stock

$82.00 $57.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Download SDS

Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01EO5T

Chemical Name:

BMS-986195

CAS Number:

1912445-55-6

Molecular Formula:

C20H23FN4O2

Molecular Weight:

370.4206

MDL Number:

MFCD31631584

SMILES:

CC#CC(=O)N[C@H]1CCCN(C1)c1c(F)cc(c2c1c(C)c([nH]2)C)C(=O)N

Properties

Computed Properties

Complexity:

657

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

2.8

Downstream Synthesis Route

1912445-95-4

1912445-55-6

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1

[3]Watterson,ScottH.;Liu,Qingjie;BeaudoinBertrand,Myra;Batt,DouglasG.;Li,Ling;Pattoli,MarkA.;Skala,Stacey;Cheng,Lihong;Obermeier,MaryT.;Moore,Robin;Yang,Zheng;Vickery,Rodney;Elzinga,PaulA.;Discenza,Lorell;D'Arienzo,Celia;Gillooly,KathleenM.;Taylor,TracyL.;Pulicicchio,Claudine;Zhang,Yifan;Heimrich,Elizabeth;McIntyre,KimW.;Ruan,Qian;Westhouse,RichardA.;Catlett,IanM.;Zheng,Naiyu;Chaudhry,Charu;Dai,Jun;Galella,MichaelA.;Tebben,AndrewJ.;Pokross,Matt;Li,Jianqing;Zhao,Rulin;Smith,Daniel;Rampulla,Richard;Allentoff,Alban;Wallace,MichaelA.;Mathur,Arvind;Salter-Cid,Luisa;Macor,JohnE.;Carter,PercyH.;Fura,Aberra;Burke,JamesR.;Tino,JosephA.[JournalofMedicinalChemistry,2019]Watterson,ScottH.;Liu,Qingjie;BeaudoinBertrand,Myra;Batt,DouglasG.;Li,Ling;Pattoli,MarkA.;Skala,Stacey;Cheng,Lihong;Obermeier,MaryT.;Moore,Robin;Yang,Zheng;Vickery,Rodney;Elzinga,PaulA.;Discenza,Lorell;D'Arienzo,Celia;Gillooly,KathleenM.;Taylor,TracyL.;Pulicicchio,Claudine;Zhang,Yifan;Heimrich,Elizabeth;McIntyre,KimW.;Ruan,Qian;Westhouse,RichardA.;Catlett,IanM.;Zheng,Naiyu;Chaudhry,Charu;Dai,Jun;Galella,MichaelA.;Tebben,AndrewJ.;Pokross,Matt;Li,Jianqing;Zhao,Rulin;Smith,Daniel;Rampulla,Richard;Allentoff,Alban;Wallace,MichaelA.;Mathur,Arvind;Salter-Cid,Luisa;Macor,JohnE.;Carter,PercyH.;Fura,Aberra;Burke,JamesR.;Tino,JosephA.[JournalofMedicinalChemistry,2019,vol.62,#7,p.3228-3250]

1912446-10-6

1912445-55-6

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1

478646-33-2

(S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1

590-93-2

(S)-4-(3-aminopiperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

(S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1Locationinpatent:Paragraph0787

[2]Watterson,ScottH.;Liu,Qingjie;BeaudoinBertrand,Myra;Batt,DouglasG.;Li,Ling;Pattoli,MarkA.;Skala,Stacey;Cheng,Lihong;Obermeier,MaryT.;Moore,Robin;Yang,Zheng;Vickery,Rodney;Elzinga,PaulA.;Discenza,Lorell;D'Arienzo,Celia;Gillooly,KathleenM.;Taylor,TracyL.;Pulicicchio,Claudine;Zhang,Yifan;Heimrich,Elizabeth;McIntyre,KimW.;Ruan,Qian;Westhouse,RichardA.;Catlett,IanM.;Zheng,Naiyu;Chaudhry,Charu;Dai,Jun;Galella,MichaelA.;Tebben,AndrewJ.;Pokross,Matt;Li,Jianqing;Zhao,Rulin;Smith,Daniel;Rampulla,Richard;Allentoff,Alban;Wallace,MichaelA.;Mathur,Arvind;Salter-Cid,Luisa;Macor,JohnE.;Carter,PercyH.;Fura,Aberra;Burke,JamesR.;Tino,JosephA.[JournalofMedicinalChemistry,2019]Watterson,ScottH.;Liu,Qingjie;BeaudoinBertrand,Myra;Batt,DouglasG.;Li,Ling;Pattoli,MarkA.;Skala,Stacey;Cheng,Lihong;Obermeier,MaryT.;Moore,Robin;Yang,Zheng;Vickery,Rodney;Elzinga,PaulA.;Discenza,Lorell;D'Arienzo,Celia;Gillooly,KathleenM.;Taylor,TracyL.;Pulicicchio,Claudine;Zhang,Yifan;Heimrich,Elizabeth;McIntyre,KimW.;Ruan,Qian;Westhouse,RichardA.;Catlett,IanM.;Zheng,Naiyu;Chaudhry,Charu;Dai,Jun;Galella,MichaelA.;Tebben,AndrewJ.;Pokross,Matt;Li,Jianqing;Zhao,Rulin;Smith,Daniel;Rampulla,Richard;Allentoff,Alban;Wallace,MichaelA.;Mathur,Arvind;Salter-Cid,Luisa;Macor,JohnE.;Carter,PercyH.;Fura,Aberra;Burke,JamesR.;Tino,JosephA.[JournalofMedicinalChemistry,2019,vol.62,#7,p.3228-3250]

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2018/45157,2018,A1Locationinpatent:Page/Pagecolumn29-31

[4]Stevens,JasonM.;Simmons,EricM.;Tan,Yichen;Borovika,Alina;Fan,Junying;Forest,RobertV.;Geng,Peng;Guerrero,CarlosA.;Lou,Sha;Skliar,Dimitri;Steinhardt,SarahE.;Strotman,NeilA.[OrganicProcessResearchandDevelopment,2022,vol.26,#4,p.1174-1183]

1912447-75-6

1912445-55-6

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2016/115126,2016,A1

Literature

Title: JR Burke, et al. BMS-986195 Is a Highly Selective and Rapidly Acting Covalent Inhibitor of Bruton’s Tyrosine Kinase with Robust Efficacy at Low Doses in Preclinical Models of RA and Lupus Nephritis. 2017 ACR/ARHP Annual Meeting, September 18, 2017.

Title: Watterson SH, et al. Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK). J Med Chem. 2019 Apr 11;62(7):3228-3250.

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SDS