[1]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[1]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[2]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[1]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[2]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[3]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[4]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[1]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[2]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[3]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[4]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[1]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[2]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[3]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
[4]Angibaud,PatrickR.;Venet,MarcG.;Filliers,Walter;Broeckx,Rudy;Ligny,YannickA.;Muller,Philippe;Poncelet,VirginieS.;End,DaveW.[EuropeanJournalofOrganicChemistry,2004,#3,p.479-486]
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Title: Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC.
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Title: Farnesyltransferase inhibitors: a comprehensive review based on quantitative structural analysis.
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Title: In vitro antifungal activity of farnesyltransferase inhibitors against clinical isolates of Aspergillus and Candida.
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Title: Effects of statins and farnesyl transferase inhibitors on ERK phosphorylation, apoptosis and cell viability in non-small lung cancer cells.
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Title: Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF.
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Title: A phase II trial of capecitabine in combination with the farnesyltransferase inhibitor tipifarnib in patients with anthracycline-treated and taxane-resistant metastatic breast cancer: an Eastern Cooperative Oncology Group Study (E1103).
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Title: Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities.
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Title: Tipifarnib-mediated suppression of T-bet-dependent signaling pathways.
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Title: Kinase inhibitors for advanced medullary thyroid carcinoma.
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Title: Tipifarnib and tanespimycin show synergic proapoptotic activity in U937 cells.
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Title: Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438).
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Title: Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia.
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Title: A phase I trial of tipifarnib with radiation therapy, with and without temozolomide, for patients with newly diagnosed glioblastoma.
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Title: Tipifarnib-induced apoptosis in acute myeloid leukemia and multiple myeloma cells depends on Ca2+ influx through plasma membrane Ca2+ channels.
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Title: Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
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Title: Inhibition of the Ras/Raf/MEK/ERK and RET kinase pathways with the combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in medullary and differentiated thyroid malignancies.
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Title: Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas.
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Title: Novel agents for the treatment of acute myeloid leukemia in the older patient.
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Title: Bostrycin inhibits proliferation of human lung carcinoma A549 cells via downregulation of the PI3K/Akt pathway.
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Title: Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.
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Title: Tipifarnib plus tamoxifen in tamoxifen-resistant metastatic breast cancer: a negative phase II and screening of potential therapeutic markers by proteomic analysis.
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Title: Present and future evolution of advanced breast cancer therapy.
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Title: Current data and strategy in glioblastoma multiforme.
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Title: Repeated responses of an elderly patient with high-risk myelodysplastic syndrome to sequential therapy with tipifarnib, 5-azacitidine, and decitabine.
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Title: The histologic spectrum of epithelial neoplasms induced by sorafenib.
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Title: Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme.
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Title: A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older.
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Title: Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide.
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Title: Tipifarnib and etoposide for older AML patients: from bench to bedside.
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Title: Combining simvastatin with the farnesyltransferase inhibitor tipifarnib results in an enhanced cytotoxic effect in a subset of primary CD34+ acute myeloid leukemia samples.
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Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090501
Title: Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer.
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Title: Determination of Ras-GTP and Ras-GDP in patients with acute myelogenous leukemia (AML), myeloproliferative syndrome (MPS), juvenile myelomonocytic leukemia (JMML), acute lymphocytic leukemia (ALL), and malignant lymphoma: assessment of mutational and indirect activation.
Journal: Annals of hematology 20090401
Title: A phase I study of tipifarnib combined with conventional induction and consolidation therapy for previously untreated patients with acute myeloid leukemia aged 60 years and over.
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Title: Phase II trial of the farnesyltransferase inhibitor tipifarnib plus fulvestrant in hormone receptor-positive metastatic breast cancer: New York Cancer Consortium Trial P6205.
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Title: Gateways to clinical trials.
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Title: Rational modification of a candidate cancer drug for use against Chagas disease.
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Title: Novel strategies for patients with chronic myeloproliferative disorders.
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Title: Applications of microarray technology to Acute Myelogenous Leukemia.
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Title: The role side effects play in the choice of antiepileptic therapy in brain tumor-related epilepsy: a comparative study on traditional antiepileptic drugs versus oxcarbazepine.
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Title: Targeted treatment of acute myeloid leukemia in older adults: role of gemtuzumab ozogamicin.
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Title: Current available therapies and future directions in the treatment of malignant gliomas.
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Title: Recent advances in systemic therapy. When HER2 is not the target: advances in the treatment of HER2-negative metastatic breast cancer.
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Title: Two-transcript gene expression classifiers in the diagnosis and prognosis of human diseases.
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Title: Managing myelodysplastic symptoms in elderly patients.
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Title: Targeted therapy in the treatment of malignant gliomas.
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Title: Phase II preradiation R115777 (tipifarnib) in newly diagnosed GBM with residual enhancing disease.
Journal: Neuro-oncology 20081201
Title: Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling.
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Title: A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.
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Title: Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches.
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Title: Interruption of the Ras/MEK/ERK signaling cascade enhances Chk1 inhibitor-induced DNA damage in vitro and in vivo in human multiple myeloma cells.
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Title: Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia.
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Title: A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy.
Journal: Breast cancer research and treatment 20080701
Title: Phase I pharmacokinetic and pharmacodynamic study of the prenyl transferase inhibitor AZD3409 in patients with advanced cancer.
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Title: Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma.
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Title: Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.
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Title: Phase II trial of tipifarnib as maintenance therapy in first complete remission in adults with acute myelogenous leukemia and poor-risk features.
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Title: Farnesyltransferase inhibitors and their potential role in therapy for myelodysplastic syndromes and acute myeloid leukaemia.
Journal: British journal of haematology 20080501
Title: Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib.
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Title: Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma.
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Title: Farnesyltransferase inhibition in hematologic malignancies: the clinical experience with tipifarnib.
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Title: Gateways to clinical trials.
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Title: A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia.
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Title: Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study.
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Title: The potential effect of statins on rituximab immunotherapy.
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Title: Phase I study of alternate-week administration of tipifarnib in patients with myelodysplastic syndrome.
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Title: Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor.
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Title: Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer.
Journal: BMC cancer 20080101
Title: Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas.
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Title: Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models.
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Title: Molecular targeted therapies for breast cancer treatment.
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Title: In vitro effects of the farnesyltransferase inhibitor tipifarnib on myelodysplastic syndrome progenitors.
Journal: Acta haematologica 20080101
Title: A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study.
Journal: Cancer 20071201
Title: Small-molecule and antibody approaches to molecular chemotherapy of primary brain tumors.
Journal: Current opinion in investigational drugs (London, England : 2000) 20071201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071201
Title: The RAS/mitogen activated protein (MAP) kinase pathway in melanoma biology and therapeutics.
Journal: Biologics : targets & therapy 20071201
Title: Tipifarnib in the treatment of acute myeloid leukemia.
Journal: Biologics : targets & therapy 20071201
Title: The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways.
Journal: International journal of cancer 20071115
Title: Novel therapeutic strategies combining antihormonal and biological targeted therapies in breast cancer: focus on clinical trials and perspectives.
Journal: Critical reviews in oncology/hematology 20071101
Title: Phase 1 study of tipifarnib in combination with imatinib for patients with chronic myelogenous leukemia in chronic phase after imatinib failure.
Journal: Cancer 20071101
Title: Tipifarnib in acute myeloid leukemia.
Journal: Drugs of today (Barcelona, Spain : 1998) 20071101
Title: Femara and the future: tailoring treatment and combination therapies with Femara.
Journal: Breast cancer research and treatment 20071001
Title: Decitabine in the treatment of myelodysplastic syndromes.
Journal: Therapeutics and clinical risk management 20071001
Title: Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
Journal: Blood 20070915
Title: A phase II trial of tipifarnib in myelofibrosis: primary, post-polycythemia vera and post-essential thrombocythemia.
Journal: Leukemia 20070901
Title: Cloning and characterization of a human BCR/ABL-positive cell line, K562/RR, resistant to the farnesyltransferase inhibition by tipifarnib.
Journal: Experimental hematology 20070901
Title: The farnesyltransferase inhibitor R115777 (tipifarnib) in combination with tamoxifen acts synergistically to inhibit MCF-7 breast cancer cell proliferation and cell cycle progression in vitro and in vivo.
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Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070901
Title: On the diversity of biological therapeutics.
Journal: Biologics : targets & therapy 20070901
Title: The molecular genetics of breast cancer and targeted therapy.
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Title: Exposure-toxicity relationships for tipifarnib in cancer patients.
Journal: British journal of clinical pharmacology 20070801
Title: Phase I trial of tipifarnib (R115777) concurrent with radiotherapy in patients with glioblastoma multiforme.
Journal: International journal of radiation oncology, biology, physics 20070801
Title: Exploiting signal transduction pathways in acute myelogenous leukemia.
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Title: Farnesyltransferase inihibitors in hematologic malignancies.
Journal: Blood reviews 20070701
Title: A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia.
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Title: A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome.
Journal: Blood 20070515
Title: The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.
Journal: Cancer research 20070515
Title: A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer.
Journal: British journal of cancer 20070507
Title: R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation.
Journal: Journal of cellular physiology 20070501
Title: Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.
Journal: European journal of medicinal chemistry 20070501
Title: The incidence and impact of thrombocytopenia in myelodysplastic syndromes.
Journal: Cancer 20070501
Title: A phase I clinical and pharmacokinetic study of tipifarnib in combination with docetaxel in patients with advanced solid malignancies.
Journal: Current medical research and opinion 20070501
Title: Massive plexiform neurofibromas in childhood: natural history and management issues.
Journal: Journal of neurosurgery 20070501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070501
Title: The farnesyl transferase inhibitor, tipifarnib, is a potent inhibitor of the MDR1 gene product, P-glycoprotein, and demonstrates significant cytotoxic synergism against human leukemia cell lines.
Journal: Leukemia 20070401
Title: Diseases of large granular lymphocytes.
Journal: Cancer control : journal of the Moffitt Cancer Center 20070401
Title: Identification of molecular predictors of response in a study of tipifarnib treatment in relapsed and refractory acute myelogenous leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070401
Title: Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Journal: Neoplasia (New York, N.Y.) 20070401
Title: Clinical activity of tipifarnib in hematologic malignancies.
Journal: Expert opinion on investigational drugs 20070301
Title: The emerging role of targeted therapy for hematologic malignancies: update on bortezomib and tipifarnib.
Journal: The oncologist 20070301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070301
Title: A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia.
Journal: Blood 20070215
Title: [Prognostic molecular marker and molecular targeted-therapy in pediatric malignancies].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070201
Title: Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (Zarnestra MT).
Journal: Carcinogenesis 20070101
Title: 48th annual meeting of the American Society of Hematology December 9-12, 2006, Orlando, FL.
Journal: Clinical lymphoma & myeloma 20070101
Title: E2902: A Phase III randomized study of farnesyl transferase inhibitor R115777 in acute myeloid leukemia patients in second or subsequent remission or in remission after primary induction failure or patients over age 60 in first remission.
Journal: Clinical advances in hematology & oncology : H&O 20070101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070101
Title: Clinical trials update: endocrine and biological therapy combinations in the treatment of breast cancer.
Journal: Breast cancer research : BCR 20070101
Title: Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex.
Journal: BMC genomics 20070101
Title: New and old treatment modalities in primary myelofibrosis.
Journal: Cancer journal (Sudbury, Mass.) 20070101
Title: Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).
Journal: Carcinogenesis 20061201
Title: Azacytidine (Vidaza(R)) in the treatment of myelodysplastic syndromes.
Journal: Therapeutics and clinical risk management 20061201
Title: Role of erlotinib in the management of pancreatic cancer.
Journal: Therapeutics and clinical risk management 20061201
Title: Effect of CYP2D6 genetic polymorphism on the population pharmacokinetics of tipifarnib.
Journal: Cancer chemotherapy and pharmacology 20061101
Title: A phase I safety, pharmacological and biological study of the farnesyl protein transferase inhibitor, tipifarnib and capecitabine in advanced solid tumors.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20061101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061101
Title: Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells.
Journal: Molecular reproduction and development 20061001
Title: Pharmacokinetics of tipifarnib after oral and intravenous administration in subjects with advanced cancer.
Journal: Journal of clinical pharmacology 20061001
Title: Clinical and pharmacologic study of the farnesyltransferase inhibitor tipifarnib in cancer patients with normal or mildly or moderately impaired hepatic function.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061001
Title: Combination therapy with aromatase inhibitors: the next era of breast cancer treatment?
Journal: British journal of cancer 20060918
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060901
Title: Phase II trial of tipifarnib in patients with recurrent malignant glioma either receiving or not receiving enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060801
Title: Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.
Journal: Carcinogenesis 20060701
Title: Phase II trial of R115777 (NSC #70818) in patients with advanced colorectal cancer: a Southwest Oncology Group study.
Journal: Investigational new drugs 20060701
Title: Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060701
Title: HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway.
Journal: Cancer research 20060701
Title: Population pharmacokinetics of tipifarnib in healthy subjects and adult cancer patients.
Journal: British journal of clinical pharmacology 20060701
Title: Gastrazole (JB95008), a novel CCK2/gastrin receptor antagonist, in the treatment of advanced pancreatic cancer: results from two randomised controlled trials.
Journal: British journal of cancer 20060424
Title: Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib.
Journal: The Journal of pharmacology and experimental therapeutics 20060401
Title: [Farnesyl transferase inhibitors--a novel agent for breast cancer].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20060401
Title: Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations.
Journal: Molecular cancer therapeutics 20060401
Title: [Molecular targets in colon cancer].
Journal: Therapeutische Umschau. Revue therapeutique 20060401
Title: Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer.
Journal: British journal of cancer 20060327
Title: Tipifarnib: farnesyl transferase inhibition at a crossroads.
Journal: Expert review of anticancer therapy 20060301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060301
Title: Farnesyltransferase inhibitors in myelodysplastic syndrome.
Journal: Current hematologic malignancy reports 20060301
Title: Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060120
Title: Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060115
Title: Non-transplant therapy for older adults with acute myeloid leukemia.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20060101
Title: Myelodysplasia: when to treat and how.
Journal: Best practice & research. Clinical haematology 20060101
Title: Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.
Journal: Breast cancer research : BCR 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051201
Title: Development of the farnesyltransferase inhibitor tipifarnib for therapy of hematologic malignancies.
Journal: Future oncology (London, England) 20051201
Title: Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra, R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours.
Journal: British journal of cancer 20051128
Title: In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib: identification of T-cell ALL and FAB M5 AML as the most sensitive subsets.
Journal: Blood 20051115
Title: Nitrogen-containing bisphosphonate incadronate augments the inhibitory effect of farnesyl transferase inhibitor tipifarnib on the growth of fresh and cloned myeloma cells in vitro.
Journal: Leukemia & lymphoma 20051101
Title: Farnesyl transferase inhibition in hematologic malignancies.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20051101
Title: A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study.
Journal: Investigational new drugs 20051001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051001
Title: Phase I trial of tipifarnib in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs: a North American Brain Tumor Consortium Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050920
Title: Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor r115777 in human epithelial cancer cells.
Journal: Frontiers in bioscience : a journal and virtual library 20050901
Title: Development of farnesyl transferase inhibitors: a review.
Journal: The oncologist 20050901
Title: The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.
Journal: Journal of medicinal chemistry 20050825
Title: Characterization of a R115777-resistant human multiple myeloma cell line with cross-resistance to PS-341.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050815
Title: Conventional and new treatment options for myelofibrosis with myeloid metaplasia.
Journal: Seminars in oncology 20050801
Title: Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.
Journal: Blood 20050615
Title: Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
Journal: Bioorganic & medicinal chemistry letters 20050602
Title: Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Journal: Journal of medicinal chemistry 20050602
Title: Relative importance of apoptosis and cell cycle blockage in the synergistic effect of combined R115777 and imatinib treatment in BCR/ABL-positive cell lines.
Journal: Biochemical pharmacology 20050601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050601
Title: A phase II trial of R115777, an oral farnesyl transferase inhibitor, in patients with advanced urothelial tract transitional cell carcinoma.
Journal: Cancer 20050515
Title: Farnesyltransferase inhibitor tipifarnib (R115777) preferentially inhibits in vitro autonomous erythropoiesis of polycythemia vera patient cells.
Journal: Blood 20050501
Title: Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: preclinical and clinical implications.
Journal: Current drug targets 20050501
Title: Farnesyltransferase inhibitors in myelodysplastic syndrome.
Journal: Current hematology reports 20050501
Title: Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20050415
Title: Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.
Journal: Cancer research 20050401
Title: In vivo apoptosis detection with radioiodinated Annexin V in LoVo tumour-bearing mice following Tipifarnib (Zarnestra, R115777) farnesyltransferase inhibitor therapy.
Journal: Nuclear medicine and biology 20050401
Title: Current and future perspectives on fulvestrant.
Journal: Clinical breast cancer 20050401
Title: Molecule of the month. Tipifarnib.
Journal: Drug news & perspectives 20050401
Title: Intermittent dosing of the farnesyl transferase inhibitor tipifarnib (R115777) in advanced malignant solid tumors: a phase I California Cancer Consortium Trial.
Journal: Anti-cancer drugs 20050301
Title: [Farnesyltransferase inhibitors: preliminary results in acute myeloid leukemia].
Journal: Bulletin du cancer 20050301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050301
Title: Farnesyltransferase inhibitors.
Journal: Clinical advances in hematology & oncology : H&O 20050301
Title: [New targets for molecular therapy of acute leukemia: a 'single-hit' or 'multiple-hit' strategy against signaling pathway].
Journal: Zhonghua yi xue za zhi 20050223
Title: Synthesis, biodistribution and effects of farnesyltransferase inhibitor therapy on tumour uptake in mice of 99mTc labelled epidermal growth factor.
Journal: Nuclear medicine communications 20050201
Title: A phase I trial and pharmacokinetic study of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in metastatic breast cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050201
Title: Farnesyltransferase inhibitor therapy in acute myelogenous leukemia.
Journal: Current hematology reports 20050101
Title: The American Society of Hematology--46th Annual Meeting and Exposition. HDAC, Flt and farnesyl transferase inhibitors.
Journal: IDrugs : the investigational drugs journal 20050101
Title: New agents in intravesical chemotherapy of superficial bladder cancer.
Journal: Scandinavian journal of urology and nephrology 20050101
Title: Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro.
Journal: Anticancer research 20050101
Title: Farnesyltransferase inhibitors.
Journal: Cancer chemotherapy and biological response modifiers 20050101
Title: New concepts in the treatment of acute myeloid malignancies: selected pathways for targeted therapy.
Journal: Journal of biological regulators and homeostatic agents 20050101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050101
Title: Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.
Journal: Breast cancer research : BCR 20050101
Title: [Problems in the current target therapy of malignancies].
Journal: Voprosy onkologii 20050101
Title: The influence of farnesyl protein transferase inhibitor R115777 (Zarnestra) alone and in combination with purine nucleoside analogs on acute myeloid leukemia progenitors in vitro.
Journal: European journal of haematology 20041201
Title: Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041201
Title: Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20041101
Title: Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20041101
Title: Clinical activity of farnesyl transferase inhibitors in hematologic malignancies: possible mechanisms of action.
Journal: Leukemia & lymphoma 20041101
Title: [Multiple myeloma: from molecular pathogenensis to the development of molecular targeting therapies].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20041101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20041101
Title: Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20041001
Title: The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate.
Journal: Oncogene 20040909
Title: Investigation of the effect of the farnesyl protein transferase inhibitor R115777 on isoprenylation and intracellular signalling by the prostacyclin receptor.
Journal: British journal of pharmacology 20040901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040901
Title: Quantile estimation following non-parametric phase I clinical trials with ordinal response.
Journal: Statistics in medicine 20040830
Title: Pharmacogenetics of tipifarnib (R115777) transport and metabolism in cancer patients.
Journal: Investigational new drugs 20040801
Title: Influence of farnesyl transferase inhibitor treatment on epidermal growth factor receptor status.
Journal: Nuclear medicine and biology 20040801
Title: Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040801
Title: Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention.
Journal: Experimental biology and medicine (Maywood, N.J.) 20040701
Title: Farnesyltransferase inhibitors as anticancer agents: critical crossroads.
Journal: Current opinion in drug discovery & development 20040701
Title: Farnesyl transferase inhibitors for patients with lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040615
Title: Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity.
Journal: Biochemistry 20040608
Title: Phase I and pharmacokinetic study of the farnesyltransferase inhibitor R115777 in combination with irinotecan in patients with advanced cancer.
Journal: Cancer chemotherapy and pharmacology 20040601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040601
Title: Farnesyltransferase inhibitor tipifarnib is well tolerated, induces stabilization of disease, and inhibits farnesylation and oncogenic/tumor survival pathways in patients with advanced multiple myeloma.
Journal: Blood 20040501
Title: Farnesyl transferase inhibitor R115777 in myelodysplastic syndrome.
Journal: Current hematology reports 20040501
Title: Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor.
Journal: British journal of cancer 20040419
Title: Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040415
Title: Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040401
Title: Targeted therapies in myelodysplastic syndromes: ASH 2003 review.
Journal: Seminars in hematology 20040401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040301
Title: R115777 induces Ras-independent apoptosis of myeloma cells via multiple intrinsic pathways.
Journal: Molecular cancer therapeutics 20040201
Title: Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
Journal: Journal of medicinal chemistry 20040129
Title: [Molecular pathogenesis of chronic myeloid leukemia and tyrosine kinase inhibitor].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20040101
Title: Microarray analysis reveals genetic pathways modulated by tipifarnib in acute myeloid leukemia.
Journal: BMC cancer 20040101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040101
Title: New targets for therapy in breast cancer: farnesyltransferase inhibitors.
Journal: Breast cancer research : BCR 20040101
Title: [Ras signaling pathway as a target for farnesyltransferase inhibitors--a new, promising prospects in the treatment for malignant disorders].
Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20040101
Title: Farnesyltransferase inhibitor R115777 in myelodysplastic syndrome: clinical and biologic activities in the phase 1 setting.
Journal: Blood 20031215
Title: 4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
Journal: Bioorganic & medicinal chemistry letters 20031215
Title: Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20031215
Title: The farnesyltransferase inhibitor R115777 reduces hypoxia and matrix metalloproteinase 2 expression in human glioma xenograft.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031201
Title: Effect of farnesyl transferase inhibitor R115777 on the growth of fresh and cloned myeloma cells in vitro.
Journal: Blood 20031101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031101
Title: A phase I, pharmacokinetic, and biological study of the farnesyltransferase inhibitor tipifarnib in combination with gemcitabine in patients with advanced malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015
Title: Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 1: Growth factor and Ras signaling pathways.
Journal: Expert review of anticancer therapy 20031001
Title: Farnesyltransferase inhibitors and their potential in the treatment of breast carcinoma.
Journal: Seminars in oncology 20031001
Title: Farnesyl transferase inhibitors in myeloid malignancies.
Journal: Blood reviews 20030901
Title: Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis.
Journal: Leukemia 20030901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030901
Title: Primary and secondary prevention of non-small-cell lung cancer: the SPORE Trials of Lung Cancer Prevention.
Journal: Clinical lung cancer 20030901
Title: Farnesyltransferase inhibitors in acute myeloid leukemia and myelodysplastic syndromes.
Journal: Clinical lymphoma 20030801
Title: New drugs in acute myeloid leukemia.
Journal: Clinical advances in hematology & oncology : H&O 20030801
Title: Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030701
Title: A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030601
Title: 5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20030505
Title: Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501
Title: Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030501
Title: In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia.
Journal: Leukemia 20030501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030501
Title: Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
Journal: Bioorganic & medicinal chemistry letters 20030407
Title: Phase II and pharmacodynamic study of the farnesyltransferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic adenocarcinoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030401
Title: Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies.
Journal: Blood 20030301
Title: Preclinical and clinical evaluation of farnesyltransferase inhibitors.
Journal: Current oncology reports 20030301
Title: Farnesyl transferase inhibitors in the treatment of breast cancer.
Journal: Expert opinion on investigational drugs 20030301
Title: Inhibiting Ras signaling in the therapy of breast cancer.
Journal: Clinical breast cancer 20030201
Title: Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002.
Journal: Cancer science 20030201
Title: Targeting RAS signalling pathways in cancer therapy.
Journal: Nature reviews. Cancer 20030101
Title: The prolyl isomerase Pin1 in breast development and cancer.
Journal: Breast cancer research : BCR 20030101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030101
Title: Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discovery.
Journal: Current topics in medicinal chemistry 20030101
Title: Farnesyltransferase inhibitors--a novel approach in the treatment of advanced pancreatic carcinomas.
Journal: Anticancer research 20030101
Title: Clinical research in pancreatic cancer: the Radiation Therapy Oncology Group trials.
Journal: International journal of radiation oncology, biology, physics 20030101
Title: Gemcitabine in the treatment of advanced pancreatic cancer: a comparative analysis of randomized trials.
Journal: Seminars in oncology 20021201
Title: [Innovative treatment in oncology].
Journal: Recenti progressi in medicina 20021101
Title: [New data presented at ASCO 2002 concerning small cell bronchial cancer].
Journal: Revue de pneumologie clinique 20021101
Title: Farnesyl transferase inhibitors as anticancer agents.
Journal: European journal of cancer (Oxford, England : 1990) 20020901
Title: Farnesyl transferase inhibitor R115777 induces apoptosis of human myeloma cells.
Journal: Leukemia 20020901
Title: Farnesyl transferase inhibitors: a major breakthrough in anticancer therapy? Naples, 12 April 2002.
Journal: Anti-cancer drugs 20020901
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020901
Title: [New therapeutic targets and strategies in lung cancer].
Journal: Archivos de bronconeumologia 20020801
Title: Evaluation of accelerator mass spectrometry in a human mass balance and pharmacokinetic study-experience with 14C-labeled (R)-6-[amino(4- chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1- methyl-2(1H)-quinolinone (R115777), a farnesyl transferase inhibitor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020701
Title: Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation.
Journal: International journal of cancer 20020701
Title: Clinical trials referral resource. Current clinical trials of R115777 (Zarnestra).
Journal: Oncology (Williston Park, N.Y.) 20020701
Title: Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020601
Title: Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020601
Title: Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis.
Journal: Clinical orthopaedics and related research 20020401
Title: Tipifarnib (Janssen Pharmaceutica).
Journal: Current opinion in investigational drugs (London, England : 2000) 20020201
Title: Evaluation of the bioequivalence of tablets and capsules containing the novel anticancer agent R115777 (Zarnestra) in patients with advanced solid tumors.
Journal: European journal of drug metabolism and pharmacokinetics 20020101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020101
Title: Agents targeting ras signaling pathway.
Journal: Current pharmaceutical design 20020101
Title: Farnesyltransferase inhibitors in breast cancer therapy.
Journal: Cancer investigation 20020101
Title: Current status of clinical trials of farnesyltransferase inhibitors.
Journal: Current opinion in oncology 20011101
Title: Preclinical antitumor activity and pharmacodynamic studies with the farnesyl protein transferase inhibitor R115777 in human breast cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20011101
Title: Farnesyltransferase inhibitors.
Journal: Seminars in oncology 20011001
Title: Cancer therapy. New strategies and treatment modalities for optimizing patient outcomes.
Journal: Seminars in hematology 20010701
Title: Farnesyl protein transferase inhibitors as targeted therapies for hematologic malignancies.
Journal: Seminars in hematology 20010701
Title: Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial.
Journal: Blood 20010601
Title: Magnetic resonance detects changes in phosphocholine associated with Ras activation and inhibition in NIH 3T3 cells.
Journal: British journal of cancer 20010301
Title: Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R115777 in patients with advanced solid tumors.
Journal: Anti-cancer drugs 20010301
Title: Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
Journal: Cancer research 20010101
Title: Farnesylated proteins and cell cycle progression.
Journal: Journal of cellular biochemistry. Supplement 20010101
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