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193153-04-7,MFCD11100277
Catalog No.:AA00ABID

193153-04-7 | Otamixaban

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10mg
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100mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABID
Chemical Name:
Otamixaban
CAS Number:
193153-04-7
Molecular Formula:
C25H26N4O4
Molecular Weight:
446.4983
MDL Number:
MFCD11100277
SMILES:
COC(=O)[C@@H]([C@H](NC(=O)c1ccc(cc1)c1cc[n+](cc1)[O-])C)Cc1cccc(c1)C(=N)N
Properties
Computed Properties
 
Complexity:
671  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
2  

Literature

Title: New parenteral anticoagulants: focus on factor Xa and thrombin inhibitors.

Journal: Current drug discovery technologies 20120601

Title: Emerging anticoagulants.

Journal: Current medicinal chemistry 20120101

Title: Inhibitors of propagation of coagulation: factors V and X.

Journal: British journal of clinical pharmacology 20111001

Title: New and emerging anticoagulant therapy for atrial fibrillation and acute coronary syndrome.

Journal: Pharmacotherapy 20111001

Title: Is there evidence to support the use of direct Factor Xa inhibitors in coronary artery disease?

Journal: Reviews on recent clinical trials 20110501

Title: Future anticoagulants in interventional cardiology: anti-IXa and anti-Xa agents in percutaneous coronary intervention.

Journal: Future cardiology 20110501

Title: Investigational factor Xa inhibitors for thrombosis and acute coronary syndromes.

Journal: Expert opinion on investigational drugs 20110401

Title: New parenteral anticoagulants in development.

Journal: Therapeutic advances in cardiovascular disease 20110201

Title: New anticoagulant agents in acute coronary syndromes.

Journal: Heart (British Cardiac Society) 20110201

Title: A network-based multi-target computational estimation scheme for anticoagulant activities of compounds.

Journal: PloS one 20110101

Title: Emerging therapies for acute coronary syndromes.

Journal: Frontiers in pharmacology 20110101

Title: Clinical pharmacology of direct and indirect factor Xa inhibitors.

Journal: Drugs 20101112

Title: Factor Xa inhibitors: next-generation antithrombotic agents.

Journal: Journal of medicinal chemistry 20100909

Title: What goes into a major acute coronary syndrome trial and what will future trials look like?

Journal: Current cardiology reports 20100701

Title: Recent research on antithrombotics. News on the treatment of patients with acute coronary syndromes.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20100501

Title: New drugs for the treatment of coronary artery syndromes: otamixaban and ticagrelor.

Journal: Expert opinion on pharmacotherapy 20100201

Title: Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice.

Journal: F1000 medicine reports 20100101

Title: Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial.

Journal: Lancet (London, England) 20090905

Title: Otamixaban in acute coronary syndromes.

Journal: Lancet (London, England) 20090905

Title: [What's new on antithrombotics?].

Journal: Annales de cardiologie et d'angeiologie 20090801

Title: [Factor Xa-inhibition in interventional cardiology].

Journal: Hamostaseologie 20071201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070901

Title: Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: the SEPIA-PCI trial.

Journal: Circulation 20070522

Title: The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development.

Journal: Current medicinal chemistry 20070101

Title: Drug evaluation: the directly activated Factor Xa inhibitor otamixaban.

Journal: IDrugs : the investigational drugs journal 20061201

Title: Direct and rapid inhibition of factor Xa by otamixaban: a pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease.

Journal: Clinical pharmacology and therapeutics 20061201

Title: Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases.

Journal: Expert opinion on investigational drugs 20060801

Title: Asymmetric synthesis of intermediates for otamixaban and premafloxacin by the chiral ligand-controlled asymmetric conjugate addition of a lithium amide.

Journal: The Journal of organic chemistry 20060609

Title: Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, and acetylsalicylic acid.

Journal: Thrombosis and haemostasis 20060201

Title: Pharmacokinetics of otamixaban, a direct factor Xa inhibitor, in healthy male subjects: pharmacokinetic model development for phase 2/3 simulation of exposure.

Journal: Journal of clinical pharmacology 20060101

Title: Pharmacokinetic/pharmacodynamic relationships for otamixaban, a direct factor Xa inhibitor, in healthy subjects.

Journal: Journal of clinical pharmacology 20060101

Title: Pharmacodynamic markers in the early clinical assessment of otamixaban, a direct factor Xa inhibitor.

Journal: Thrombosis and haemostasis 20051201

Title: Anticoagulant and anti-platelet effects are maintained following coadministration of otamixaban, a direct factor Xa inhibitor, with tirofiban in healthy volunteers.

Journal: Thrombosis and haemostasis 20050401

Title: Small molecule coagulation cascade inhibitors in the clinic.

Journal: Current topics in medicinal chemistry 20050101

Title: Optimization of the beta-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity.

Journal: Bioorganic & medicinal chemistry letters 20020617

Title: Pharmacological characterization of a novel factor Xa inhibitor, FXV673.

Journal: Thrombosis research 20010815

Title: Role of short-term inhibition of factor Xa by FXV673 in arterial passivation: a study in a chronic model of thrombosis in conscious dogs.

Journal: Journal of cardiovascular pharmacology 20010801

Title: Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombolysis.

Journal: British journal of pharmacology 20010801

Title: Eikelboom JW, Weitz JI.Otamixaban in acute coronary syndromes.Lancet. 2009 Sep 5;374(9692):762-4. Epub 2009 Aug 28.

Title: Sabatine MS, Antman EM, et al. Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial.Lancet. 2009 Sep 5;374(9692):787-95. Epub 2009 Aug 28

Title: Guertin KR, Choi YM.The discovery of the Factor Xa inhibitor otamixaban: from lead identification to clinical development.Curr Med Chem. 2007;14(23):2471-81.

Title: Cohen M, Bhatt DL, et al. SEPIA-PCI Trial Investigators.Randomized, double-blind, dose-ranging study of otamixaban, a novel, parenteral, short-acting direct factor Xa inhibitor, in percutaneous coronary intervention: the SEPIA-PCI trial.Circulation. 2007

Title: Guertin, Kevin R.; Choi, Yong-Mi.The discovery of the factor Xa inhibitor Otamixaban: from lead identification to clinical development.Current Medicinal Chemistry (2007), 14(23), 2471-2481.

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