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194085-75-1,MFCD15071195
Catalog No.:AA0074MP

194085-75-1 | 1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbamate, (1S)-

Pack Size
Purity
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1mg
98%
in stock  
$236.00   $165.00
- +
5mg
98%
in stock  
$654.00   $458.00
- +
10mg
98%
in stock  
$950.00   $665.00
- +
25mg
98%
in stock  
$1,725.00   $1,208.00
- +
50mg
98%
in stock  
$2,557.00   $1,790.00
- +
100mg
98%
in stock  
$3,807.00   $2,665.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0074MP
Chemical Name:
1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbamate, (1S)-
CAS Number:
194085-75-1
Molecular Formula:
C9H10ClNO3
Molecular Weight:
215.6336
MDL Number:
MFCD15071195
SMILES:
NC(=O)OCC(c1ccccc1Cl)O
Properties
Computed Properties
 
Complexity:
201  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1  

Literature

Title: Effect of carisbamate on the pharmacokinetics and pharmacodynamics of warfarin in healthy participants.

Journal: Journal of clinical pharmacology 20120901

Title: Novel medication targets for the treatment of alcoholism: preclinical studies.

Journal: Recent patents on CNS drug discovery 20120801

Title: Effect of mild and moderate hepatic impairment on the pharmacokinetics and safety of carisbamate.

Journal: Journal of clinical pharmacology 20120501

Title: Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.

Journal: Journal of medicinal chemistry 20120322

Title: Carisbamate (RWJ-333369) inhibits glutamate transmission in the granule cell of the dentate gyrus.

Journal: Neuropharmacology 20111201

Title: CONSORT recommendations in abstracts of randomised, controlled trials on migraine and headache.

Journal: The journal of headache and pain 20111001

Title: Cognitive effects of carisbamate in randomized, placebo-controlled, healthy-volunteer, multidose studies.

Journal: Epilepsy & behavior : E&B 20111001

Title: Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls.

Journal: Cephalalgia : an international journal of headache 20111001

Title: Carisbamate acutely suppresses spasms in a rat model of symptomatic infantile spasms.

Journal: Epilepsia 20110901

Title: A randomized, double-blind, placebo-controlled study of the efficacy, safety, and tolerability of adjunctive carisbamate treatment in patients with partial-onset seizures.

Journal: Epilepsia 20110401

Title: Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: Carisbamate has powerful disease-modifying effects in the lithium-pilocarpine model of temporal lobe epilepsy.

Journal: Neuropharmacology 20110101

Title: Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X).

Journal: Epilepsy research 20101201

Title: Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research.

Journal: Pharmacological reviews 20101201

Title: 'Epileptic encephalopathy' of infancy and childhood: electro-clinical pictures and recent understandings.

Journal: Current neuropharmacology 20101201

Title: Emerging drugs for partial onset seizures.

Journal: Expert opinion on emerging drugs 20100901

Title: Antiepileptic drug interactions - principles and clinical implications.

Journal: Current neuropharmacology 20100901

Title: Carisbamate in essential tremor: brief report of a proof of concept study.

Journal: Movement disorders : official journal of the Movement Disorder Society 20100415

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100401

Title: Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100401

Title: Carisbamate as adjunctive treatment of partial onset seizures in adults in two randomized, placebo-controlled trials.

Journal: Epilepsia 20100301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100301

Title: What is the promise of new antiepileptic drugs in status epilepticus? Focus on brivaracetam, carisbamate, lacosamide, NS-1209, and topiramate.

Journal: Epilepsia 20091201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090901

Title: Carisbamate, a novel antiepileptic candidate compound, attenuates alcohol intake in alcohol-preferring rats.

Journal: Alcoholism, clinical and experimental research 20090801

Title: Pharmacokinetics of carisbamate (RWJ-333369) in healthy Japanese and Western subjects.

Journal: Epilepsia 20090801

Title: Investigation of the effects of the novel anticonvulsant compound carisbamate (RWJ-333369) on rat piriform cortical neurones in vitro.

Journal: British journal of pharmacology 20090301

Title: Evaluation of carisbamate for the treatment of migraine in a randomized, double-blind trial.

Journal: Headache 20090201

Title: Quantitative determination of polymorphic impurity by X-ray powder diffractometry in an OROS formulation.

Journal: International journal of pharmaceutics 20090121

Title: Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX).

Journal: Epilepsy research 20090101

Title: Carisbamate, a novel neuromodulator, inhibits voltage-gated sodium channels and action potential firing of rat hippocampal neurons.

Journal: Epilepsy research 20090101

Title: Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.

Journal: Pharmacological reports : PR 20090101

Title: Pregabalin for the management of partial epilepsy.

Journal: Neuropsychiatric disease and treatment 20081201

Title: Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures.

Journal: Neurology 20081111

Title: One-pot conversion of trimethylsilyl ethers into urethanes using chlorosulfonyl isocyanate: application to the synthesis of a novel neuromodulator carisbamate.

Journal: Archives of pharmacal research 20081101

Title: Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons.

Journal: Epilepsia 20081001

Title: A new potential AED, carisbamate, substantially reduces spontaneous motor seizures in rats with kainate-induced epilepsy.

Journal: Epilepsia 20081001

Title: The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons.

Journal: Epilepsy research 20080501

Title: Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS.

Journal: Epilepsia 20080301

Title: Pharmacokinetics, safety, and tolerability of the new antiepileptic carisbamate in the elderly.

Journal: Epilepsy research 20080301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080301

Title: Pharmacological management of epilepsy: recent advances and future prospects.

Journal: Drugs 20080101

Title: Pharmacotherapy of essential tremor : an overview of existing and upcoming agents.

Journal: CNS drugs 20080101

Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.

Journal: Perspectives in medicinal chemistry 20080101

Title: Carisbamate, a new carbamate for the treatment of epilepsy.

Journal: IDrugs : the investigational drugs journal 20071001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070901

Title: An interaction study between the new antiepileptic and CNS drug carisbamate (RWJ-333369) and lamotrigine and valproic acid.

Journal: Epilepsia 20070701

Title: Evaluation of carisbamate, a novel antiepileptic drug, in photosensitive patients: an exploratory, placebo-controlled study.

Journal: Epilepsy research 20070501

Title: The absorption, metabolism, and excretion of the novel neuromodulator RWJ-333369 (1,2-ethanediol, [1-2-chlorophenyl]-, 2-carbamate, [S]-) in humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070401

Title: Metabolism and excretion of RWJ-333369 [1,2-ethanediol, 1-(2-chlorophenyl)-, 2-carbamate, (S)-] in mice, rats, rabbits, and dogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070401

Title: Carisbamate (RWJ-333369).

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101

Title: The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury.

Journal: Restorative neurology and neuroscience 20070101

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Tags:194085-75-1 Molecular Formula|194085-75-1 MDL|194085-75-1 SMILES|194085-75-1 1,2-Ethanediol,1-(2-chlorophenyl)-, 2-carbamate, (1S)-