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195875-84-4,MFCD18633271
Catalog No.:AA00ADK8

195875-84-4 | Tesofensine

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5mg
≥95%
in stock  
$416.00   $291.00
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10mg
≥95%
in stock  
$790.00   $553.00
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50mg
≥95%
in stock  
$1,870.00   $1,309.00
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100mg
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$3,323.00   $2,326.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ADK8
Chemical Name:
Tesofensine
CAS Number:
195875-84-4
Molecular Formula:
C17H23Cl2NO
Molecular Weight:
328.2766
MDL Number:
MFCD18633271
SMILES:
CCOC[C@H]1[C@H]2CC[C@H](N2C)C[C@@H]1c1ccc(c(c1)Cl)Cl
Properties
Computed Properties
 
Complexity:
354  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
4.5  

Literature

Title: Anti-obesity drugs: a review about their effects and their safety.

Journal: Expert opinion on drug safety 20120501

Title: Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20120401

Title: [The pharmacological treatment of obesity: past, present and future].

Journal: Orvosi hetilap 20120311

Title: The effect of tesofensine on appetite sensations.

Journal: Obesity (Silver Spring, Md.) 20120301

Title: Anti-Obesity Drugs: A Review about Their Effects and Safety.

Journal: Diabetes & metabolism journal 20120201

Title: New acetylcholinesterase inhibitors for Alzheimer's disease.

Journal: International journal of Alzheimer's disease 20120101

Title: Pharmacological management of binge eating disorder: current and emerging treatment options.

Journal: Therapeutics and clinical risk management 20120101

Title: Serotonergic anti-obesity agents: past experience and future prospects.

Journal: Drugs 20111203

Title: Neuropsychiatric adverse effects of centrally acting antiobesity drugs.

Journal: CNS neuroscience & therapeutics 20111001

Title: Current and future drug targets in weight management.

Journal: Pharmaceutical research 20110801

Title: Comparative efficiency and safety of pharmacological approaches to the management of obesity.

Journal: Diabetes care 20110501

Title: Assessment of acute and chronic pharmacological effects on energy expenditure and macronutrient oxidation in humans: responses to ephedrine.

Journal: Journal of obesity 20110101

Title: Pharmacotherapies for obesity: past, current, and future therapies.

Journal: Journal of obesity 20110101

Title: Pharmacological treatment of obesity in children and adolescents: present and future.

Journal: Journal of obesity 20110101

Title: Weight gain, obesity, and psychotropic prescribing.

Journal: Journal of obesity 20110101

Title: Present and future: pharmacologic treatment of obesity.

Journal: Journal of obesity 20110101

Title: Usage, risk, and benefit of weight-loss drugs in primary care.

Journal: Journal of obesity 20110101

Title: Management of diabetes across the course of disease: minimizing obesity-associated complications.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20110101

Title: The effect of the triple monoamine reuptake inhibitor tesofensine on energy metabolism and appetite in overweight and moderately obese men.

Journal: International journal of obesity (2005) 20101101

Title: New approaches to the pharmacological treatment of obesity: can they break through the efficacy barrier?

Journal: Pharmacology, biochemistry, and behavior 20101101

Title: [Recent progress and novel perspectives on obesity pharmacotherapy].

Journal: Arquivos brasileiros de endocrinologia e metabologia 20100801

Title: Subjective and objective effects of the novel triple reuptake inhibitor tesofensine in recreational stimulant users.

Journal: Clinical pharmacology and therapeutics 20100701

Title: The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant.

Journal: European journal of pharmacology 20100625

Title: Quantitative pharmacology approach in Alzheimer's disease: efficacy modeling of early clinical data to predict clinical outcome of tesofensine.

Journal: The AAPS journal 20100601

Title: Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601

Title: Effect of centchroman coadministration on the pharmacokinetics of metformin in rats.

Journal: Indian journal of pharmacology 20100601

Title: Pharmacological management of appetite expression in obesity.

Journal: Nature reviews. Endocrinology 20100501

Title: Semi-mechanistic population pharmacokinetic drug-drug interaction modelling of a long half-life substrate and itraconazole.

Journal: Clinical pharmacokinetics 20100101

Title: [Drug treatment of obesity--current situation and perspectives].

Journal: Casopis lekaru ceskych 20100101

Title: Tackling obesity: new therapeutic agents for assisted weight loss.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

Title: [Is there a future for medical treatment of obesity?].

Journal: Ugeskrift for laeger 20091005

Title: [The effect of tesofensine on body weight and body composition in obese subjects--secondary publication].

Journal: Ugeskrift for laeger 20091005

Title: Tesofensine, a monoamine reuptake inhibitor for the treatment of obesity.

Journal: Current opinion in investigational drugs (London, England : 2000) 20091001

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090901

Title: Tesofensine--a novel potent weight loss medicine. Evaluation of: Astrup A, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1906-13.

Journal: Expert opinion on investigational drugs 20090701

Title: Tesofensine and weight loss.

Journal: Lancet (London, England) 20090227

Title: Tesofensine and weight loss.

Journal: Lancet (London, England) 20090227

Title: Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes.

Journal: PloS one 20090101

Title: A quantitative enterohepatic circulation model: development and evaluation with tesofensine and meloxicam.

Journal: Clinical pharmacokinetics 20090101

Title: Triple reuptake inhibitors: the next generation of antidepressants.

Journal: Current neuropharmacology 20081201

Title: Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial.

Journal: Lancet (London, England) 20081129

Title: Is new hope on the horizon for obesity?

Journal: Lancet (London, England) 20081129

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20081001

Title: Triple reuptake inhibitors: a premise and promise.

Journal: Psychiatry investigation 20080901

Title: Weight loss produced by tesofensine in patients with Parkinson's or Alzheimer's disease.

Journal: Obesity (Silver Spring, Md.) 20080601

Title: Tesofensine (NS 2330), a monoamine reuptake inhibitor, in patients with advanced Parkinson disease and motor fluctuations: the ADVANS Study.

Journal: Archives of neurology 20080501

Title: Contribution of the active metabolite M1 to the pharmacological activity of tesofensine in vivo: a pharmacokinetic-pharmacodynamic modelling approach.

Journal: British journal of pharmacology 20080101

Title: Population pharmacokinetic modelling of NS2330 (tesofensine) and its major metabolite in patients with Alzheimer's disease.

Journal: British journal of clinical pharmacology 20070701

Title: Randomized trial of the triple monoamine reuptake inhibitor NS 2330 (tesofensine) in early Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society 20070215

Title: Expression of brain derived neurotrophic factor, activity-regulated cytoskeleton protein mRNA, and enhancement of adult hippocampal neurogenesis in rats after sub-chronic and chronic treatment with the triple monoamine re-uptake inhibitor tesofensine.

Journal: European journal of pharmacology 20070126

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation.

Journal: Neural plasticity 20070101

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