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19666-76-3,MFCD00210540
Catalog No.:AA00I3I3

19666-76-3 | Panaxadiol

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Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$128.00   $90.00
- +
250mg
95%
in stock  
$245.00   $171.00
- +
500mg
95%
in stock  
$378.00   $264.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I3I3
Chemical Name:
Panaxadiol
CAS Number:
19666-76-3
Molecular Formula:
C30H52O3
Molecular Weight:
460.7321
MDL Number:
MFCD00210540
SMILES:
OC1CC2C3(C)CCC(C(C3CCC2(C2(C1C(CC2)C1(C)CCCC(O1)(C)C)C)C)(C)C)O
Properties
Computed Properties
 
Complexity:
789  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
6.9  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells.

Journal: The Journal of pharmacy and pharmacology 20120501

Title: Study on the structure-function relationship of 20(S)-panaxadiol and its epimeric derivatives in myocardial injury induced by isoproterenol.

Journal: Fitoterapia 20101001

Title: Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation.

Journal: Cancer letters 20100801

Title: The effects of ginseng total saponin, panaxadiol and panaxatriol on ischemia/reperfusion injury in isolated rat heart.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

Title: Letter to the editor: Panaxadiol's anticancer activity is enhanced by epicatechin.

Journal: The American journal of Chinese medicine 20100101

Title: Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells.

Journal: Cancer chemotherapy and pharmacology 20091101

Title: Synthesis of dammarane-type triterpene derivatives and their ability to inhibit HIV and HCV proteases.

Journal: Bioorganic & medicinal chemistry 20090415

Title: Panaxadiol glycosides that induce neuronal differentiation in neurosphere stem cells.

Journal: Journal of natural products 20070801

Title: [Effects of Ginseng panaxadiol saponin on proliferation and differentiation of human bone marrow CD34+ cells].

Journal: Zhongguo shi yan xue ye xue za zhi 20070801

Title: Modulating effect of ginseng saponins on heterologously expressed HERG currents in Xenopus oocytes.

Journal: Acta pharmacologica Sinica 20050501

Title: [Effect of panaxadiol saponin and panaxtrol saponin on proliferation of human bone marrow hemopoietic progenitor cells].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040201

Title: Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells.

Journal: Carcinogenesis 20031101

Title: Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis.

Journal: Biochemical and biophysical research communications 20030613

Title: Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China.

Journal: Acta pharmacologica Sinica 20011201

Title: Wang Z, et al. Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells. Pharmacol Res. 2020;155:104727.

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