Title: Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110701
Title: Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways.
Journal: Fundamental & clinical pharmacology 20100201
Title: An increased regional blood flow precedes mesenteric inflammation in rats treated by a phosphodiesterase 4 inhibitor.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090101
Title: Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Journal: Journal of medicinal chemistry 20080925
Title: Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071101
Title: Altered gene expression in rat mesenteric tissue following in vivo exposure to a phosphodiesterase 4 inhibitor.
Journal: Toxicology and applied pharmacology 20070101
Title: The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients.
Journal: Pulmonary pharmacology & therapeutics 20050101
Title: Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors.
Journal: Life sciences 20040702
Title: Pruniaux MP, et al. Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways. Fundam Clin Pharmacol. 2010 Feb;24(1):73-82.
