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198419-90-8,MFCD10565942
Catalog No.:AA00ATB3

198419-90-8 | (+/-)-LY367385

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1mg
≥98%
in stock  
$89.00   $62.00
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5mg
≥98%
in stock  
$278.00   $194.00
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10mg
≥98%
in stock  
$510.00   $357.00
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25mg
≥98%
in stock  
$1,170.00   $819.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ATB3
Chemical Name:
(+/-)-LY367385
CAS Number:
198419-90-8
Molecular Formula:
C10H11NO4
Molecular Weight:
209.1986
MDL Number:
MFCD10565942
SMILES:
OC(=O)c1ccc(c(c1)C)C(C(=O)O)N
Properties
Computed Properties
 
Complexity:
266  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-1.8  

Literature

Title: Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.

Journal: Journal of neurophysiology 20111101

Title: Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110316

Title: Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons.

Journal: The European journal of neuroscience 20110301

Title: Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100929

Title: Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100801

Title: Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability.

Journal: The European journal of neuroscience 20090601

Title: Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

Journal: The European journal of neuroscience 20080301

Title: A role for protein kinase A and protein kinase M zeta in muscarinic acetylcholine receptor-initiated persistent synaptic enhancement in rat hippocampus in vivo.

Journal: Neuroscience 20080124

Title: Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning.

Journal: Neurobiology of learning and memory 20071001

Title: Functional and ultrastructural analysis of group I mGluR in striatal fast-spiking interneurons.

Journal: The European journal of neuroscience 20070301

Title: Glutamate pretreatment affects Ca2+ signaling in processes of astrocyte pairs.

Journal: Journal of neurochemistry 20070101

Title: Metabotropic glutamate receptors in the main olfactory bulb drive granule cell-mediated inhibition.

Journal: Journal of neurophysiology 20070101

Title: Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease.

Journal: The European journal of neuroscience 20051001

Title: Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long-term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N-methyl-D-aspartate and metabotropic glutamate receptor-dependent mechanisms.

Journal: The European journal of neuroscience 20050101

Title: Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat.

Journal: Neuroscience 20050101

Title: Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents.

Journal: Experimental neurology 20031001

Title: The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson's disease.

Journal: Neuroscience 20030101

Title: Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices.

Journal: Journal of neurophysiology 20021001

Title: Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780.

Title: V Bruno, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. europharmacology. 1999 Feb;38(2):199-207.

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Tags:198419-90-8 Molecular Formula|198419-90-8 MDL|198419-90-8 SMILES|198419-90-8 (+/-)-LY367385