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199666-03-0,MFCD11040807
Catalog No.:AA002C73

199666-03-0 | 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

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1mg
98%
in stock  
$7.00   $5.00
- +
5mg
98%
in stock  
$12.00   $8.00
- +
10mg
98%
in stock  
$17.00   $12.00
- +
25mg
98%
in stock  
$34.00   $24.00
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50mg
98%
in stock  
$56.00   $39.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002C73
Chemical Name:
3,4-Dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide
CAS Number:
199666-03-0
Molecular Formula:
C17H15N3O6S2
Molecular Weight:
421.4475
MDL Number:
MFCD11040807
SMILES:
COc1cc(ccc1OC)S(=O)(=O)Nc1scc(n1)c1cccc(c1)[N+](=O)[O-]
Properties
Computed Properties
 
Complexity:
638  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
3.2  

Downstream Synthesis Route

[1]Patent:WO2008/22281,2008,A1.Locationinpatent:Page/Pagecolumn59

[2]JournalofMedicinalChemistry,1997,vol.40,p.4378-4385

50-00-0    124-40-3    199666-03-0   
3,4-dimethoxy-N-4-(3-nitro-phenyl)-5-dimethylaminomethyl-1,3-thiazol-2-ylbenzenesulfonamide 

[1]Patent:WO2008/22281,2008,A1.Locationinpatent:Page/Pagecolumn59-60

50-00-0    199666-03-0   
C18H17N3O7S2 

[1]Patent:WO2008/22281,2008,A1.Locationinpatent:Page/Pagecolumn61-62

199666-03-0    74-88-4   
3,4-dimethoxy-N-4-(3-nitrophenyl)-thiazol-2-yl-N-(methyl)-benzenesulfonamide 

[1]Patent:WO2008/22281,2008,A1.Locationinpatent:Page/Pagecolumn66-67

activecharcoal 
  23095-31-0   
4-(3-nitrophenyl)thiazol-2-aminehydrobromidesalt 
  199666-03-0 

[1]Patent:US5877193,1999,A

Literature

Title: The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal.

Journal: PloS one 20120101

Title: Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

Journal: Cell 20110610

Title: Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis.

Journal: Journal of neuropathology and experimental neurology 20101101

Title: Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.

Journal: Neuropharmacology 20100101

Title: Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias.

Journal: Journal of molecular neuroscience : MN 20090601

Title: Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.

Journal: Brain : a journal of neurology 20090501

Title: Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.

Journal: International journal for parasitology 20090201

Title: Kynurenine pathway metabolites in humans: disease and healthy States.

Journal: International journal of tryptophan research : IJTR 20090101

Title: Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant.

Journal: European journal of pharmacology 20080531

Title: Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.

Journal: Behavioural brain research 20080125

Title: Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys.

Journal: Movement disorders : official journal of the Movement Disorder Society 20050701

Title: Kynurenine 3-mono-oxygenase inhibitors reduce glutamate concentration in the extracellular spaces of the basal ganglia but not in those of the cortex or hippocampus.

Journal: Neuropharmacology 20050501

Title: The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.

Journal: European journal of pharmacology 20030930

Title: Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.

Journal: Journal of neurochemistry 20020901

Title: Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis.

Journal: Neuroscience 20010101

Title: S Röver, et al. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. J Med Chem. 1997 Dec 19;40(26):4378-85.

Title: Melanie Hamann, et al. Effects of the kynurenine 3-hydroxylase inhibitor Ro 61-8048 after intrastriatal injections on the severity of dystonia in the dt sz mutant. Eur J Pharmacol. 2008 May 31;586(1-3):156-9.

Title: AlbertoChiarugi, et al. Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl) thiazol-2yl-benzenesulfonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase. Neuropharmacology. Volume 38, Issue 8, August 1999, Pages 1225-1233.

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