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20153-98-4,MFCD00133267
Catalog No.:AA00C4EY

20153-98-4 | DILAZEP DIHYDROCHLORIDE

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5mg
≥98%
in stock  
$89.00   $62.00
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10mg
≥98%
in stock  
$149.00   $104.00
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25mg
≥98%
in stock  
$302.00   $211.00
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100mg
95%
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$404.00   $283.00
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250mg
95%
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$758.00   $531.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C4EY
Chemical Name:
DILAZEP DIHYDROCHLORIDE
CAS Number:
20153-98-4
Molecular Formula:
C31H46Cl2N2O10
Molecular Weight:
677.6103
MDL Number:
MFCD00133267
SMILES:
COc1cc(cc(c1OC)OC)C(=O)OCCCN1CCCN(CC1)CCCOC(=O)c1cc(OC)c(c(c1)OC)OC.Cl.Cl
Properties
Computed Properties
 
Complexity:
727  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
18  

Downstream Synthesis Route

[1]Playa,Hilaire;Lewis,TimothyA.;Ting,Amal;Suh,Byung-Chul;Muoz,Benito;Matuza,Robert;Passer,BrentJ.;Schreiber,StuartL.;Buolamwini,JohnK.[BioorganicandMedicinalChemistryLetters,2014,vol.24,#24,p.5801-5804]

[1]Playa,Hilaire;Lewis,TimothyA.;Ting,Amal;Suh,Byung-Chul;Muoz,Benito;Matuza,Robert;Passer,BrentJ.;Schreiber,StuartL.;Buolamwini,JohnK.[BioorganicandMedicinalChemistryLetters,2014,vol.24,#24,p.5801-5804]

Literature

Title: Residue Ile89 in human plasma membrane monoamine transporter influences its organic cation transport activity and sensitivity to inhibition by dilazep.

Journal: Biochemical pharmacology 20120801

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Estimation of endogenous adenosine activity at adenosine receptors in guinea-pig ileum using a new pharmacological method.

Journal: Acta physiologica (Oxford, England) 20100601

Title: Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication.

Journal: Cancer research 20100515

Title: Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells.

Journal: Journal of pharmacological sciences 20100101

Title: Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity.

Journal: The Biochemical journal 20080901

Title: Behçet's disease complicated by IgA nephropathy with nephrotic syndrome.

Journal: Clinical and experimental nephrology 20080601

Title: Visualisation of the effects of dilazep on rat afferent and efferent arterioles in vivo.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080201

Title: Nucleoside and nucleobase transporters of primary human cardiac microvascular endothelial cells: characterization of a novel nucleobase transporter.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: Residues 334 and 338 in transmembrane segment 8 of human equilibrative nucleoside transporter 1 are important determinants of inhibitor sensitivity, protein folding, and catalytic turnover.

Journal: The Journal of biological chemistry 20070511

Title: Meta-analysis of antiplatelet therapy for IgA nephropathy.

Journal: Clinical and experimental nephrology 20061201

Title: Long-term effect of imidapril hydrochloride compared with dilazep hydrochloride administration on blood pressure and renal function in patients with chronic glomerulonephritis.

Journal: International heart journal 20050701

Title: Immunotactoid glomerulopathy with microtubular deposits, with reference to the characteristics of Japanese cases.

Journal: Clinical nephrology 20050501

Title: Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites.

Journal: Molecular pharmacology 20050401

Title: Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride.

Journal: Diabetes/metabolism research and reviews 20050101

Title: Characterization of monocyte tissue factor activity induced by IgG antiphospholipid antibodies and inhibition by dilazep.

Journal: Blood 20041015

Title: Dilazep and dipyridamole inhibit tissue factor expression on monocytes induced by IgG from patients with antiphospholipid syndrome.

Journal: Acta pharmacologica Sinica 20041001

Title: Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cells.

Journal: British journal of pharmacology 20040901

Title: Cardiac mechanical dysfunction induced by ischemia-reperfusion in perfused heart isolated from stroke-prone spontaneously hypertensive rats.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20040801

Title: Endothelin-1 gene expression in endothelial cells is potently inhibited by a vasodilator, dilazep.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20040601

Title: [(3)H]Adenosine uptake in brainstem membranes of CD-1 mice lacking the adenosine A(2a) receptor.

Journal: Life sciences 20040528

Title: Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1.

Journal: The Biochemical journal 20040515

Title: Pharmacological analysis and molecular cloning of the canine equilibrative nucleoside transporter 1.

Journal: European journal of pharmacology 20040426

Title: Inhibition of glucose uptake in murine cardiomyocyte cell line HL-1 by cardioprotective drugs dilazep and dipyridamole.

Journal: American journal of physiology. Heart and circulatory physiology 20040201

Title: Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.

Journal: Biochemical pharmacology 20040201

Title: Efficacy of prednisolone and mizoribine therapy for diffuse IgA nephropathy.

Journal: American journal of nephrology 20040101

Title: Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells.

Journal: European journal of pharmacology 20030815

Title: Combination AST-120 and dilazep dihydrochloride therapy reduced urinary protein excretion and serum creatinine levels in patients with chronic renal failure.

Journal: Renal failure 20020901

Title: Effects of a nucleoside transporter inhibitor, dilazep, on renal microcirculation in rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20020701

Title: Mutation of residue 33 of human equilibrative nucleoside transporters 1 and 2 alters sensitivity to inhibition of transport by dilazep and dipyridamole.

Journal: The Journal of biological chemistry 20020104

Title: Steroid therapy and urinary transforming growth factor-beta1 in IgA nephropathy.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20011201

Title: Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).

Journal: The Journal of biological chemistry 20010126

Title: Dilazep hydrochloride, an antiplatelet drug, inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation.

Journal: Kidney & blood pressure research 20010101

Title: A vasoactive agent enhances the effect of ATP on cochlear blood flow.

Journal: Acta oto-laryngologica 20010101

Title: Dipyridamole and dilazep suppress oxygen radicals in puromycin aminonucleoside nephrosis rats.

Journal: European journal of clinical investigation 19981101

Title: Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues.

Journal: The Journal of biological chemistry 19971107

Title: Functional characterization of a recombinant sodium-dependent nucleoside transporter with selectivity for pyrimidine nucleosides (cNT1rat) by transient expression in cultured mammalian cells.

Journal: The Biochemical journal 19960715

Title: Zhang Y, et al. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258(3):767-71.

Title: Kawagoe J, et al. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345(4):485-8.

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