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20311-51-7,MFCD30207844
Catalog No.:AA00BF3P

20311-51-7 | Solamargine

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Purity
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1mg
≥95%
in stock  
$98.00   $68.00
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5mg
98%
in stock  
$311.00   $218.00
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20mg
in stock  
$504.00   $353.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF3P
Chemical Name:
Solamargine
CAS Number:
20311-51-7
Molecular Formula:
C45H73NO15
Molecular Weight:
868.0588
MDL Number:
MFCD30207844
SMILES:
OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@]3(O4)CC[C@H](CN3)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1610  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
26  
Heavy Atom Count:
61  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
7  
XLogP3:
1.1  

Literature

Title: Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.

Journal: Fitoterapia 20120901

Title: Solasodine rhamnosyl glycosides cause apoptosis in cancer cells. Do they also prime the immune system resulting in long-term protection against cancer?

Journal: Planta medica 20120301

Title: In situ RBL receptor visualization and its mediated anticancer activity for solasodine rhamnosides.

Journal: Chembiochem : a European journal of chemical biology 20111104

Title: [Extraction, purification technology and antineoplastic effects of solamargine].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

Title: Quantitative determination and pharmacokinetic study of solamargine in rat plasma by liquid chromatography-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20110715

Title: [Simultaneous determination of three steroidal alkaloids from Solanum Nigrum by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

Title: Total synthesis of solamargine.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells.

Journal: Cancer chemotherapy and pharmacology 20110401

Title: Technology of compact MAb and its application for medicinal plant breeding named as missile type molecular breeding.

Journal: Current drug discovery technologies 20110301

Title: Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20110220

Title: Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells.

Journal: Life sciences 20110214

Title: A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100901

Title: Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.

Journal: Bioscience reports 20090201

Title: Biological activity of alkaloids from Solanum dulcamara L.

Journal: Natural product research 20090101

Title: Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin.

Journal: Chemical research in toxicology 20080201

Title: Downregulation of HER2/neu receptor by solamargine enhances anticancer drug-mediated cytotoxicity in breast cancer cells with high-expressing HER2/neu.

Journal: Cell biology and toxicology 20080101

Title: Solamargine induces apoptosis and sensitizes breast cancer cells to cisplatin.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071101

Title: Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells.

Journal: Molecular nutrition & food research 20070801

Title: Structures of steroidal alkaloid oligoglycosides, robeneosides A and B, and antidiabetogenic constituents from the Brazilian medicinal plant Solanum lycocarpum.

Journal: Journal of natural products 20070201

Title: Impaired female sexual behavior of rat offspring exposed to Solanum lycocarpum unripe fruits during gestation and lactation: lack of hormonal and fertility alterations.

Journal: Pharmacology, biochemistry, and behavior 20050801

Title: Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants.

Journal: Plant cell reports 20031201

Title: Absence of interceptive effect in rats treated with Solanum lycocarpum (St. Hil).

Journal: Contraception 20010101

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