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203450-07-1,MFCD09840782
Catalog No.:AA00C2MB

203450-07-1 | 5'-HYDROXY THALIDOMIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
2 weeks  
$2,529.00   $1,770.00
- +
2mg
2 weeks  
$4,318.00   $3,023.00
- +
5mg
2 weeks  
$7,365.00   $5,155.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00C2MB
Chemical Name:
5'-HYDROXY THALIDOMIDE
CAS Number:
203450-07-1
Molecular Formula:
C13H10N2O5
Molecular Weight:
274.2289
MDL Number:
MFCD09840782
SMILES:
O[C@H]1C[C@H](C(=O)NC1=O)N1C(=O)c2c(C1=O)cccc2
NSC Number:
726792
Properties
Computed Properties
 
Complexity:
479  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.2  

Literature

Title: Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide.

Journal: Chemical research in toxicology 20140121

Title: In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

Journal: Chemical research in toxicology 20120220

Title: Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.

Journal: Chemical research in toxicology 20100621

Title: Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide.

Journal: Organic & biomolecular chemistry 20080507

Title: Comparative molecular field analysis and comparative molecular similarity indices analysis of thalidomide analogues as angiogenesis inhibitors.

Journal: Journal of medicinal chemistry 20040422

Title: 5'-OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis.

Journal: Therapeutic drug monitoring 20020201

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SDS
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Tags:203450-07-1 Molecular Formula|203450-07-1 MDL|203450-07-1 SMILES|203450-07-1 5'-HYDROXY THALIDOMIDE
Catalog No.: AA00C2MB
203450-07-1,MFCD09840782
203450-07-1 | 5'-HYDROXY THALIDOMIDE
Pack Size： 1mg
Purity：
2 weeks
$2,529.00 $1,770.00
Pack Size： 2mg
Purity：
2 weeks
$4,318.00 $3,023.00
Pack Size： 5mg
Purity：
2 weeks
$7,365.00 $5,155.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00C2MB
Chemical Name: 5'-HYDROXY THALIDOMIDE
CAS Number: 203450-07-1
Molecular Formula: C13H10N2O5
Molecular Weight: 274.2289
MDL Number: MFCD09840782
SMILES: O[C@H]1C[C@H](C(=O)NC1=O)N1C(=O)c2c(C1=O)cccc2
NSC Number: 726792
Properties
Complexity: 479  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 2  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.2  
Literature fold

Title: Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide.

Journal: Chemical research in toxicology20140121

Title: In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

Journal: Chemical research in toxicology20120220

Title: Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.

Journal: Chemical research in toxicology20100621

Title: Enzymatic resolution and evaluation of enantiomers of cis-5'-hydroxythalidomide.

Journal: Organic & biomolecular chemistry20080507

Title: Comparative molecular field analysis and comparative molecular similarity indices analysis of thalidomide analogues as angiogenesis inhibitors.

Journal: Journal of medicinal chemistry20040422

Title: 5'-OH-thalidomide, a metabolite of thalidomide, inhibits angiogenesis.

Journal: Therapeutic drug monitoring20020201

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