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204205-90-3,MFCD05861105
Catalog No.:AA00299J

204205-90-3 | 2-(1-(4-Chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide

Pack Size
Purity
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Price(USD)
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5mg
98%
in stock  
$100.00   $70.00
- +
10mg
≥95%
in stock  
$158.00   $110.00
- +
25mg
98%
in stock  
$267.00   $187.00
- +
50mg
≥95%
in stock  
$513.00   $359.00
- +
100mg
98%
in stock  
$743.00   $520.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00299J
Chemical Name:
2-(1-(4-Chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
CAS Number:
204205-90-3
Molecular Formula:
C22H16ClN3O2
Molecular Weight:
389.8343
MDL Number:
MFCD05861105
SMILES:
Clc1ccc(cc1)Cn1cc(c2c1cccc2)C(=O)C(=O)Nc1ccncc1
Properties
Computed Properties
 
Complexity:
558  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.9  

Literature

Title: [Molecular dynamics simulation of the tubulin dimer with cytostatics].

Journal: Molekuliarnaia biologiia 20120101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20101201

Title: Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.

Journal: Investigational new drugs 20100401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100101

Title: Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies.

Journal: Journal of medicinal chemistry 20091008

Title: Synthesis and structure-activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents.

Journal: Bioorganic & medicinal chemistry 20090915

Title: Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin.

Journal: Cancer research 20090101

Title: Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents.

Journal: Journal of enzyme inhibition and medicinal chemistry 20081001

Title: Design, synthesis and cytotoxicity of novel podophyllotoxin derivatives.

Journal: Chemical & pharmaceutical bulletin 20080601

Title: Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: In vivo evaluation of indolyl glyoxamides in the phenotypic sea urchin embryo assay.

Journal: Chemical biology & drug design 20071201

Title: Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors.

Journal: Investigational new drugs 20070601

Title: Antirestenotic effects of a novel polymer-coated d-24851 eluting stent. Experimental data in a rabbit iliac artery model.

Journal: Cardiovascular and interventional radiology 20070101

Title: Microtubule inhibitor D-24851 induces p53-independent apoptotic cell death in malignant glioma cells through Bcl-2 phosphorylation and Bax translocation.

Journal: International journal of oncology 20050301

Title: Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies.

Journal: Molecular pharmacology 20011101

Title: D-24851, a novel synthetic microtubule inhibitor, exerts curative antitumoral activity in vivo, shows efficacy toward multidrug-resistant tumor cells, and lacks neurotoxicity.

Journal: Cancer research 20010101

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Tags:204205-90-3 Molecular Formula|204205-90-3 MDL|204205-90-3 SMILES|204205-90-3 2-(1-(4-Chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide