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20554-84-1,MFCD00134592
Catalog No.:AA002A43

20554-84-1 | Parthenolide

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1mg
97% HPLC
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100mg
97% HPLC
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250mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002A43
Chemical Name:
Parthenolide
CAS Number:
20554-84-1
Molecular Formula:
C15H20O3
Molecular Weight:
248.3175
MDL Number:
MFCD00134592
SMILES:
C/C/1=C\CC[C@@]2(C)O[C@@H]2[C@@H]2[C@@H](CC1)C(=C)C(=O)O2
Properties
Computed Properties
 
Complexity:
437  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
2.3  

Downstream Synthesis Route
20554-84-1   
(11<i>S</i>)-5ξ,6α-dihydroxy-4ξ<i>H</i>,10ξ<i>H</i>-germacran-12-oicacid-6-lactone 

[1]CollectionofCzechoslovakChemicalCommunications,1961,vol.26,p.803-810

67-56-1    20554-84-1   
platinum 
  2513-76-0 

[1]CollectionofCzechoslovakChemicalCommunications,1961,vol.26,p.803-810

Literature

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters 20150105

Title: Elucidation and in planta reconstitution of the parthenolide biosynthetic pathway.

Journal: Metabolic engineering 20140501

Title: Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937.

Journal: Arthritis research & therapy 20140101

Title: Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.

Journal: Toxicology and applied pharmacology 20131101

Title: Resveratrol induces nuclear factor-κB activity in human cardiac cells.

Journal: International journal of cardiology 20130910

Title: NF-κB pathway contributes to cadmium-induced apoptosis of porcine granulosa cells.

Journal: Biological trace element research 20130601

Title: Role of 15-hydroxyeicosatetraenoic acid in hemozoin-induced lysozyme release from human adherent monocytes.

Journal: BioFactors (Oxford, England) 20130101

Title: Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide.

Journal: Anti-cancer drugs 20121001

Title: Parthenolide inhibits the LPS-induced secretion of IL-6 and TNF-α and NF-κB nuclear translocation in BV-2 microglia.

Journal: Phytotherapy research : PTR 20120901

Title: Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells.

Journal: Basic & clinical pharmacology & toxicology 20120901

Title: TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes.

Journal: Biochimica et biophysica acta 20120901

Title: Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma.

Journal: Molecular medicine reports 20120901

Title: Biomimetic semisynthesis of arglabin from parthenolide.

Journal: The Journal of organic chemistry 20120817

Title: Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model.

Journal: Experimental & molecular medicine 20120731

Title: TWEAK (tumor necrosis factor-like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation.

Journal: Kidney international 20120601

Title: Culture supernatants of breast cancer cell line MDA-MB-231 treated with parthenolide inhibit the proliferation, migration, and lumen formation capacity of human umbilical vein endothelial cells.

Journal: Chinese medical journal 20120601

Title: Mixed micelles of PEG(2000)-DSPE and vitamin-E TPGS for concurrent delivery of paclitaxel and parthenolide: enhanced chemosenstization and antitumor efficacy against non-small cell lung cancer (NSCLC) cell lines.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

Title: Bcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosis.

Journal: Cancer letters 20120501

Title: Patch testing with constituents of Compositae mixes.

Journal: Contact dermatitis 20120501

Title: Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities.

Journal: Inflammation 20120401

Title: Inhibition of Myb-dependent gene expression by the sesquiterpene lactone mexicanin-I.

Journal: Leukemia 20120401

Title: Targeting radioresistant osteosarcoma cells with parthenolide.

Journal: Journal of cellular biochemistry 20120401

Title: 9β-hydroxyparthenolide esters from Inula montbretiana and their antiprotozoal activity.

Journal: Planta medica 20120201

Title: Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo.

Journal: Journal of biochemical and molecular toxicology 20120101

Title: Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.

Journal: Chemical biology & drug design 20120101

Title: Parthenolide, an inhibitor of the nuclear factor-κB pathway, ameliorates dextran sulfate sodium-induced colitis in mice.

Journal: International immunopharmacology 20120101

Title: HIV-1 Tat protein impairs adipogenesis and induces the expression and secretion of proinflammatory cytokines in human SGBS adipocytes.

Journal: Antiviral therapy 20120101

Title: Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina.

Journal: The International journal of developmental biology 20120101

Title: Thermosensitization and induction of apoptosis or cell-cycle arrest via the MAPK cascade by parthenolide, an NF-κB inhibitor, in human prostate cancer androgen-independent cell lines.

Journal: International journal of molecular medicine 20111201

Title: Parthenolide attenuates LPS-induced fever, circulating cytokines and markers of brain inflammation in rats.

Journal: Cytokine 20111201

Title: Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments.

Journal: Journal of medicinal chemistry 20111124

Title: Effects of nuclear factor-κB inhibitors on colon anastomotic healing in rats.

Journal: The Journal of surgical research 20111101

Title: Biosynthesis and localization of parthenolide in glandular trichomes of feverfew (Tanacetum parthenium L. Schulz Bip.).

Journal: Phytochemistry 20111001

Title: Involvement of endoplasmic reticulum stress-mediated CHOP (GADD153) induction in the cytotoxicity of 2-aminophenoxazine-3-one in cancer cells.

Journal: International journal of oncology 20111001

Title: Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro.

Journal: Molecules (Basel, Switzerland) 20110809

Title: Selenoprotein-dependent up-regulation of hematopoietic prostaglandin D2 synthase in macrophages is mediated through the activation of peroxisome proliferator-activated receptor (PPAR) gamma.

Journal: The Journal of biological chemistry 20110805

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Molecular pathways of spontaneous and TNF-{alpha}-mediated neutrophil apoptosis under intermittent hypoxia.

Journal: American journal of respiratory cell and molecular biology 20110701

Title: CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors.

Journal: Cytokine 20110701

Title: Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation.

Journal: Journal of cellular physiology 20110601

Title: The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.

Journal: Leukemia & lymphoma 20110601

Title: Tissue factor pathway inhibitor 2 is induced by thrombin in human macrophages.

Journal: Biochimica et biophysica acta 20110601

Title: A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-κB and generating reactive oxygen species.

Journal: International journal of cancer 20110515

Title: The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-κB inhibition.

Journal: Thrombosis research 20110501

Title: Parthenolide inhibits STAT3 signaling and attenuates angiotensin II-induced left ventricular hypertrophy via modulation of fibroblast activity.

Journal: Journal of molecular and cellular cardiology 20110401

Title: Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.

Journal: Hypertension (Dallas, Tex. : 1979) 20110401

Title: Parthenolide inhibits TRIF-dependent signaling pathway of Toll-like receptors in RAW264.7 macrophages.

Journal: Molecules and cells 20110331

Title: Contribution of a nuclear factor-kappaB binding site to human angiotensinogen promoter activity in renal proximal tubular cells.

Journal: Hypertension (Dallas, Tex. : 1979) 20110301

Title: Suppression of intracellular calcium levels and inhibition of degranulation in RBL-2H3 mast cells by the sesquiterpene lactone parthenolide.

Journal: Planta medica 20110201

Title: NFκB inhibitors induce cell death in glioblastomas.

Journal: Biochemical pharmacology 20110201

Title: Glyceroneogenesis is inhibited through HIV protease inhibitor-induced inflammation in human subcutaneous but not visceral adipose tissue.

Journal: Journal of lipid research 20110201

Title: Screening for Compositae sensitization with pure allergens: implications of molecular structure, strength of reaction, and time of testing.

Journal: Contact dermatitis 20110201

Title: In vitro anti HSV-1 and HSV-2 activity of Tanacetum vulgare extracts and isolated compounds: an approach to their mechanisms of action.

Journal: Phytotherapy research : PTR 20110201

Title: Parthenolide, an NF-κB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer.

Journal: Cancer genomics & proteomics 20110101

Title: The NFĸB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways.

Journal: Blood 20101223

Title: Synergistic effects of parthenolide and benznidazole on Trypanosoma cruzi.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101215

Title: Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells.

Journal: Experimental & molecular medicine 20101130

Title: Paclitaxel efficacy is increased by parthenolide via nuclear factor-kappaB pathways in in vitro and in vivo human non-small cell lung cancer models.

Journal: Current cancer drug targets 20101101

Title: Small molecule inhibitors of IkappaB kinase signaling inhibit osteoclast formation in vitro and prevent ovariectomy-induced bone loss in vivo.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20101101

Title: Myeloperoxidase expression as a potential determinant of parthenolide-induced apoptosis in leukemia bulk and leukemia stem cells.

Journal: The Journal of pharmacology and experimental therapeutics 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11).

Journal: International journal of oncology 20101101

Title: MTA1 coregulator regulates LPS response via MyD88-dependent signaling.

Journal: The Journal of biological chemistry 20101022

Title: The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.

Journal: British journal of haematology 20101001

Title: Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons.

Journal: American journal of physiology. Cell physiology 20100901

Title: Patch test reactivity to feverfew-containing creams in feverfew-allergic patients.

Journal: Contact dermatitis 20100901

Title: Chlamydial infection of monocytes stimulates IL-1beta secretion through activation of the NLRP3 inflammasome.

Journal: Microbes and infection 20100801

Title: In vivo analysis of gut function and disease changes in a zebrafish larvae model of inflammatory bowel disease: a feasibility study.

Journal: Inflammatory bowel diseases 20100701

Title: Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.

Journal: Natural product research 20100701

Title: Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells.

Journal: British journal of pharmacology 20100701

Title: Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells.

Journal: European journal of pharmacology 20100610

Title: BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100601

Title: Ghrelin decreases microvascular leak during inflammation.

Journal: The Journal of trauma 20100501

Title: Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1 alpha,25-dihydroxyvitamin D3.

Journal: Journal of leukocyte biology 20100501

Title: Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.

Journal: Journal of neuroimmunology 20100415

Title: A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells.

Journal: Cancer research 20100401

Title: Nuclear-targeted inhibition of NF-kappaB on MMP-9 production by N-2-(4-bromophenyl) ethyl caffeamide in human monocytic cells.

Journal: Chemico-biological interactions 20100330

Title: Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.

Journal: The Journal of biological chemistry 20100326

Title: [Molecular mechanisms of parthenolide's action: Old drug with a new face].

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20100316

Title: Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator.

Journal: The Journal of biological chemistry 20100305

Title: Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis.

Journal: Planta medica 20100201

Title: Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro.

Journal: Melanoma research 20100201

Title: IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.

Journal: Immunology letters 20100104

Title: Inhibition of NF-kappaB by combination therapy with parthenolide and hyperthermia and kinetics of apoptosis induction and cell cycle arrest in human lung adenocarcinoma cells.

Journal: International journal of molecular medicine 20100101

Title: [Effect of parthenolide on leukemia K562 cells and its leukemia stem cells].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.

Journal: Molecular cancer 20100101

Title: Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro.

Journal: Journal of experimental & clinical cancer research : CR 20100101

Title: [Parthenolide inhibits neuroinflammation and promotes neurogenesis in the ischemic striatum following transient middle cerebral artery occlusion in the adult rat brain].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20091101

Title: Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1).

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.

Journal: Expert opinion on investigational drugs 20090801

Title: NF-kappaB regulates androgen receptor expression and prostate cancer growth.

Journal: The American journal of pathology 20090801

Title: Effect of parthenolide on proliferation and apoptosis in gastric cancer cell line SGC7901.

Journal: Journal of digestive diseases 20090801

Title: Screening biomaterials for stimulation of nitric oxide-mediated inflammation.

Journal: Journal of biomedical materials research. Part A 20090701

Title: CTGF promotes inflammatory cell infiltration of the renal interstitium by activating NF-kappaB.

Journal: Journal of the American Society of Nephrology : JASN 20090701

Title: Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo.

Journal: Molecular cancer research : MCR 20090701

Title: Parthenolide inhibits proliferation of vascular smooth muscle cells through induction of G0/G1 phase cell cycle arrest.

Journal: Journal of Zhejiang University. Science. B 20090701

Title: Tanacetum vulgare: antiherpes virus activity of crude extract and the purified compound parthenolide.

Journal: Phytotherapy research : PTR 20090601

Title: Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach.

Journal: The Prostate 20090601

Title: Nuclear factor-[kappa]B inhibition provides additional protection against ischaemia/reperfusion injury in delayed sevoflurane preconditioning.

Journal: European journal of anaesthesiology 20090601

Title: Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

Journal: The Journal of pharmacology and experimental therapeutics 20090501

Title: IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20090501

Title: Sesquiterpene lactone parthenolide ameliorates bladder inflammation and bladder overactivity in cyclophosphamide induced rat cystitis model by inhibiting nuclear factor-kappaB phosphorylation.

Journal: The Journal of urology 20090501

Title: A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells.

Journal: Pancreas 20090501

Title: Resistance of cholangiocarcinoma cells to parthenolide-induced apoptosis by the excretory-secretory products of Clonorchis sinensis.

Journal: Parasitology research 20090401

Title: Inhibition of NF-kB and metalloproteinase-9 expression and secretion by parthenolide derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090401

Title: Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

Journal: British journal of pharmacology 20090401

Title: Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells.

Journal: Radiation research 20090401

Title: JP-8 induces immune suppression via a reactive oxygen species NF-kappabeta-dependent mechanism.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090301

Title: Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions.

Journal: Molecular cancer therapeutics 20090301

Title: Anti-inflammatory activity of parthenolide-depleted Feverfew (Tanacetum parthenium).

Journal: Inflammopharmacology 20090201

Title: Chemosensitization in non-small cell lung cancer cells by IKK inhibitor occurs via NF-kappaB and mitochondrial cytochrome c cascade.

Journal: Journal of cellular and molecular medicine 20090101

Title: Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Journal: BMC systems biology 20090101

Title: Modulation of cell surface protein free thiols: a potential novel mechanism of action of the sesquiterpene lactone parthenolide.

Journal: PloS one 20090101

Title: Cardiotrophin-1 induces intercellular adhesion molecule-1 expression by nuclear factor kappaB activation in human umbilical vein endothelial cells.

Journal: Chinese medical journal 20081220

Title: Depressant-like effects of parthenolide in a rodent behavioural antidepressant test battery.

Journal: The Journal of pharmacy and pharmacology 20081201

Title: Cytotoxic effects of catechol to neuroblastoma N2a cells.

Journal: General physiology and biophysics 20081201

Title: IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

Journal: Rheumatology (Oxford, England) 20081101

Title: Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.

Journal: Clinical advances in hematology & oncology : H&O 20081101

Title: NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells.

Journal: Breast cancer research and treatment 20081001

Title: Inhibitory effects of parthenolide on the angiogenesis induced by human multiple myeloma cells and the mechanism.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081001

Title: Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells.

Journal: Molecular pharmacology 20080801

Title: Parthenolide inhibits proliferation of fibroblast-like synoviocytes in vitro.

Journal: Inflammation 20080801

Title: Antileukemic activity of aminoparthenolide analogs.

Journal: Bioorganic & medicinal chemistry letters 20080715

Title: A potential target associated with both cancer and cancer stem cells: a combination therapy for eradication of breast cancer using vinorelbine stealthy liposomes plus parthenolide stealthy liposomes.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20080702

Title: Inhibition of Nod2 signaling and target gene expression by curcumin.

Journal: Molecular pharmacology 20080701

Title: Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.

Journal: Blood 20080615

Title: Inhibitory effects of parthenolide on antigen-induced microtubule formation and degranulation in mast cells.

Journal: International immunopharmacology 20080601

Title: Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.

Journal: Journal of applied toxicology : JAT 20080501

Title: Thermosensitization by parthenolide in human lung adenocarcinoma A549 cells and p53- and hsp72-independent apoptosis induction via the nuclear factor-kappaB signal pathway.

Journal: International journal of molecular medicine 20080501

Title: Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.

Journal: Biochemical and biophysical research communications 20080418

Title: Potentiation of arsenic trioxide cytotoxicity by Parthenolide and buthionine sulfoximine in murine and human leukemic cells.

Journal: Cancer chemotherapy and pharmacology 20080401

Title: Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.

Journal: Pharmacology, biochemistry, and behavior 20080401

Title: Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians.

Journal: European journal of pharmacology 20080331

Title: [Parthenolide inhibits tumor necrosis factor-alpha induced catabolism of aggrecan in chondrocytes in osteoarthritis: in vitro experiment with cultured human chondrocytes].

Journal: Zhonghua yi xue za zhi 20080318

Title: Antimyeloma effects of a sesquiterpene lactone parthenolide.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080315

Title: Trypanosoma cruzi: antiprotozoal activity of parthenolide obtained from Tanacetum parthenium (L.) Schultz Bip. (Asteraceae, Compositae) against epimastigote and amastigote forms.

Journal: Experimental parasitology 20080301

Title: Parthenolide-depleted Feverfew (Tanacetum parthenium) protects skin from UV irradiation and external aggression.

Journal: Archives of dermatological research 20080201

Title: Parthenolide induces apoptosis in glioblastomas without affecting NF-kappaB.

Journal: Journal of pharmacological sciences 20080201

Title: The lipophilic hapten parthenolide induces interferon-gamma and interleukin-13 production by peripheral blood-derived CD8+ T cells from contact allergic subjects in vitro.

Journal: The British journal of dermatology 20080101

Title: Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.

Journal: Genome biology 20080101

Title: Implications of the involvement of the endoplasmic reticulum stress pathway in drug-induced apoptosis.

Journal: Anticancer research 20080101

Title: Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20080101

Title: Molecular basis of parthenolide-dependent proapoptotic activity in cancer cells.

Journal: Folia histochemica et cytobiologica 20080101

Title: An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells.

Journal: Blood 20071215

Title: Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-kappaB and split-dose repair.

Journal: Radiation research 20071201

Title: The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-kappaB inhibition and enhanced by the presence of PTEN.

Journal: Molecular cancer therapeutics 20070901

Title: Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells.

Journal: Cancer letters 20070828

Title: Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS.

Journal: Journal of cellular physiology 20070801

Title: Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury.

Journal: American journal of physiology. Renal physiology 20070701

Title: Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated.

Journal: Chemistry & biology 20070701

Title: Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.

Journal: International journal of cancer 20070615

Title: Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice.

Journal: American journal of respiratory cell and molecular biology 20070601

Title: Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9.

Journal: Cell research 20070601

Title: Suppression of pancreatic tumor growth by combination chemotherapy with sulindac and LC-1 is associated with cyclin D1 inhibition in vivo.

Journal: Molecular cancer therapeutics 20070601

Title: The solution and solid state stability and excipient compatibility of parthenolide in feverfew.

Journal: AAPS PharmSciTech 20070601

Title: Modulation of the chemokines KC and MCP-1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice.

Journal: Archives of biochemistry and biophysics 20070515

Title: Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.

Journal: Life sciences 20070403

Title: Parthenolide inhibits tubulin carboxypeptidase activity.

Journal: Cancer research 20070401

Title: Toll-like receptor 2 and 4 combination engagement upregulate IL-15 synergistically in human rheumatoid synovial fibroblasts.

Journal: Immunology letters 20070315

Title: Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes.

Journal: Biochimica et biophysica acta 20070301

Title: Compositae dermatitis from airborne parthenolide.

Journal: The British journal of dermatology 20070301

Title: The leukemic stem cell.

Journal: Best practice & research. Clinical haematology 20070301

Title: Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes.

Journal: Free radical biology & medicine 20070215

Title: Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20070215

Title: TNF-alpha induces transient resistance to Fas-induced apoptosis in eosinophilic acute myeloid leukemia cells.

Journal: Cellular & molecular immunology 20070201

Title: Parthenolide reduces cisplatin-induced renal damage.

Journal: Toxicology 20070125

Title: Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070101

Title: Quantitative estimation of parthenolide in Tanacetum parthenium (L.) Schultz-Bip. cultivated in Egypt.

Journal: Journal of AOAC International 20070101

Title: Understanding interactions between and among apoptosis inducing pathways in tumor cells.

Journal: In vivo (Athens, Greece) 20070101

Title: Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells.

Journal: Pharmacological reports : PR 20070101

Title: Antiapoptotic proteins as targets for bioactive compounds.

Journal: Polish journal of veterinary sciences 20070101

Title: Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity.

Journal: Apoptosis : an international journal on programmed cell death 20061201

Title: Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.

Journal: Cytokine 20061101

Title: Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model.

Journal: The Prostate 20061001

Title: Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction.

Journal: Planta medica 20061001

Title: Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20060801

Title: [Proliferation inhibiting and apoptosis inducing effects of parthenolide on human multiple myeloma cells].

Journal: Zhonghua yi xue za zhi 20060725

Title: Estrogen dependent growth inhibitory effects of tamoxifen but not genistein in solid tumors derived from estrogen receptor positive (ER+) primary breast carcinoma MCF7: single agent and novel combined treatment approaches.

Journal: Bulletin du cancer 20060701

Title: Quantification of parthenolide in Tanacetum species by LC-UV/LC-MS and microscopic comparison of Mexican/US feverfew samples.

Journal: Die Pharmazie 20060701

Title: Artemisolide from Artemisia asiatica: nuclear factor-kappaB (NF-kappaB) inhibitor suppressing prostaglandin E2 and nitric oxide production in macrophages.

Journal: Archives of pharmacal research 20060701

Title: The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro.

Journal: Leukemia 20060601

Title: Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.

Journal: Molecular cancer research : MCR 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Platelet-activating factor induces up-regulation of antiapoptotic factors in a melanoma cell line through nuclear factor-kappaB activation.

Journal: Cancer research 20060501

Title: Pyrogenicity of CpG-DNA in mice: role of interleukin-6, cyclooxygenases, and nuclear factor-kappaB.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060401

Title: Contact allergy to herbal teas derived from Asteraceae plants.

Journal: Contact dermatitis 20060401

Title: Parthenolide has limited effects on nuclear factor-kappa beta increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice.

Journal: Cytokine 20060321

Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

Journal: Journal of cellular biochemistry 20060201

Title: CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27.

Journal: Experimental dermatology 20060201

Title: Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo.

Journal: The Journal of endocrinology 20060201

Title: Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.

Journal: Endocrinology 20060101

Title: Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines.

Journal: Journal of medicinal food 20060101

Title: Probing protein function with small molecules.

Journal: Ernst Schering Research Foundation workshop 20060101

Title: Inhibition of DMXAA-induced tumor necrosis factor production in murine splenocyte cultures by NF-kappaB inhibitors.

Journal: Oncology research 20060101

Title: Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways.

Journal: Carcinogenesis 20051201

Title: Prevention of the ultraviolet B-mediated skin photoaging by a nuclear factor kappaB inhibitor, parthenolide.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: Processing of a sesquiterpene lactone by Papilio glaucus caterpillars.

Journal: Journal of chemical ecology 20051101

Title: Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells.

Journal: Biochimica et biophysica acta 20050915

Title: Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.

Journal: The Journal of investigative dermatology 20050901

Title: Feverfew: weeding out the root of leukaemia.

Journal: Expert opinion on biological therapy 20050901

Title: [Effects of parthenolide on the activity and expression of urokinase type plasminogen activator in PGCL3 cells].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050901

Title: Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine.

Journal: Cephalalgia : an international journal of headache 20050801

Title: Altered NF-kappaB gene expression and collagen formation induced by polyunsaturated fatty acids.

Journal: The Journal of nutritional biochemistry 20050801

Title: Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis.

Journal: Cancer research 20050715

Title: Intracellular redox state regulation by parthenolide.

Journal: Biochemical and biophysical research communications 20050701

Title: NF-kappaB and NOS may play a role in human RPMI-8402 cell apoptosis.

Journal: Cell biology international 20050701

Title: Role of interleukin 6 (IL-6)/IL-6R-induced signal tranducers and activators of transcription and mitogen-activated protein kinase/extracellular.

Journal: The Journal of rheumatology 20050701

Title: The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells.

Journal: Blood 20050601

Title: The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer.

Journal: Molecular cancer therapeutics 20050601

Title: Parthenolide and abscisic acid synthesis in feverfew are associated but environmental factors affect them dissimilarly.

Journal: Journal of plant physiology 20050501

Title: Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy.

Journal: The Journal of biological chemistry 20050429

Title: Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.

Journal: Cell death and differentiation 20050401

Title: Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.

Journal: Cancer research 20050401

Title: Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells.

Journal: Molecular cancer therapeutics 20050401

Title: Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

Journal: Journal of biochemistry and molecular biology 20050331

Title: Transcription factors as targets of the anti-inflammatory treatment. A cell culture study with extracts from some Mediterranean diet plants.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050301

Title: NF-kappa B activation is not required for Chlamydia trachomatis inhibition of host epithelial cell apoptosis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050201

Title: A potent apoptosis-inducing activity of a sesquiterpene lactone, arucanolide, in HL60 cells: a crucial role of apoptosis-inducing factor.

Journal: Journal of pharmacological sciences 20050201

Title: The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells.

Journal: Molecular cancer therapeutics 20050101

Title: Sabarubicin- (MEN 10755) and paclitaxel show different kinetics in nuclear factor-kappaB (NF-kB) activation: effect of parthenolide on their cytotoxicity.

Journal: Anticancer research 20050101

Title: Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis.

Journal: Oncogene 20041118

Title: Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells.

Journal: Carcinogenesis 20041101

Title: Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20041101

Title: Microtubule-interfering activity of parthenolide.

Journal: Chemico-biological interactions 20041015

Title: Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot.

Journal: Pharmacology, biochemistry, and behavior 20041001

Title: Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase.

Journal: Oncogene 20040923

Title: Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin-1.

Journal: Acta pharmacologica Sinica 20040901

Title: Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

Journal: Cancer letters 20040810

Title: Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms.

Journal: Carcinogenesis 20040801

Title: Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer.

Journal: Investigational new drugs 20040801

Title: Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential.

Journal: Life sciences 20040702

Title: NF-kappa B inhibition markedly enhances sensitivity of resistant breast cancer tumor cells to tamoxifen.

Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040601

Title: The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release.

Journal: European journal of immunology 20040601

Title: Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells.

Journal: Cancer letters 20040528

Title: Modulation of inhibitor kappaB kinase/ nuclear factor kappaB signaling during critical illness: a double-edged sword.

Journal: Critical care medicine 20040501

Title: Native LDL induces interleukin-8 expression via H2O2, p38 Kinase, and activator protein-1 in human aortic smooth muscle cells.

Journal: Cardiovascular research 20040401

Title: Effect of C-reactive protein on chemokine expression in human aortic endothelial cells.

Journal: Journal of molecular and cellular cardiology 20040301

Title: NF-kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability.

Journal: Stroke 20040201

Title: Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest.

Journal: Anticancer research 20040101

Title: Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death.

Journal: Redox report : communications in free radical research 20040101

Title: Regulation of expression of stromyelysin-1 by proinflammatory cytokines in mouse brain astrocytes.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20031201

Title: Transport of parthenolide across human intestinal cells (Caco-2).

Journal: Planta medica 20031101

Title: Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew).

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031001

Title: Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.

Journal: FEBS letters 20030925

Title: Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis.

Journal: Critical care medicine 20030901

Title: Nuclear factor-kappaB: is it a therapeutic target for the adjuvant treatment of sepsis?

Journal: Critical care medicine 20030901

Title: NF-kappaB inhibitor sesquiterpene parthenolide induces concurrently atypical apoptosis and cell necrosis: difficulties in identification of dead cells in such cultures.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030801

Title: Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis.

Journal: Stroke 20030701

Title: [Sbudies on the effect of parthenolide on the proliferation of rat vascular smooth muscle cells and the mechanism].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030701

Title: Parthenolide and its photochemically synthesized 1(10)Z isomer: chemical reactivity and structure-activity relationship studies in human leucocyte chemotaxis.

Journal: Bioorganic & medicinal chemistry 20030403

Title: Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030215

Title: Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury. Shock 17(2):127-134, 2002.

Journal: Shock (Augusta, Ga.) 20030201

Title: JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.

Journal: The Journal of biological chemistry 20030131

Title: Inhibitors of diverse metabolic steps cause increased apoptosis in deoxyadenosine-resistant mouse leukemia L1210 cells that lack p53 expression: convergence at caspase-3 activation.

Journal: Advances in enzyme regulation 20030101

Title: Cell cycle effects and caspase-dependent and independent death of HL-60 and Jurkat cells treated with the inhibitor of NF-kappaB parthenolide.

Journal: Cell cycle (Georgetown, Tex.) 20030101

Title: Characterization of the molecular events following impairment of NF-kappaB-driven transcription in neurons.

Journal: Brain research. Molecular brain research 20021230

Title: The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.

Journal: European journal of immunology 20021201

Title: The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells.

Journal: Cell death and differentiation 20021101

Title: Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells.

Journal: Journal of neuroimmunology 20021101

Title: GADD153-mediated anticancer effects of N-(4-hydroxyphenyl)retinamide on human hepatoma cells.

Journal: The Journal of biological chemistry 20021011

Title: Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide.

Journal: The Journal of biological chemistry 20021011

Title: Nuclear factor-kappa B inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis.

Journal: The American journal of pathology 20021001

Title: Variations in parthenolide content and daily dose of feverfew products.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020815

Title: The sesquiterpene lactone parthenolide inhibits LPS- but not TNF-alpha-induced maturation of human monocyte-derived dendritic cells by inhibition of the p38 mitogen-activated protein kinase pathway.

Journal: The Journal of allergy and clinical immunology 20020801

Title: Characterization of a novel mammalian phosphatase having sequence similarity to Schizosaccharomyces pombe PHO2 and Saccharomyces cerevisiae PHO13.

Journal: Biochemistry 20020618

Title: Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents.

Journal: Molecular pharmacology 20020501

Title: Phytochemical inhibition of interleukin-4-activated Stat6 and expression of VCAM-1.

Journal: Biochemical and biophysical research communications 20020412

Title: Nuclear factor-kappaB as a molecular target for migraine therapy.

Journal: Annals of neurology 20020401

Title: Enhancement of 1 alpha,25-dihydroxyvitamin D(3)-induced differentiation of human leukaemia HL-60 cells into monocytes by parthenolide via inhibition of NF-kappa B activity.

Journal: British journal of pharmacology 20020301

Title: Sesquiterpene lactone parthenolide, an inhibitor of IkappaB kinase complex and nuclear factor-kappaB, exerts beneficial effects in myocardial reperfusion injury.

Journal: Shock (Augusta, Ga.) 20020201

Title: Lactacystin, a proteasome inhibitor, potentiates the apoptotic effect of parthenolide, an inhibitor of NFkappaB activation, on drug-resistant mouse leukemia L1210 cells.

Journal: Anticancer research 20020101

Title: GC determination of parthenolide in feverfew products.

Journal: Die Pharmazie 20011201

Title: Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones.

Journal: The Journal of biological chemistry 20011026

Title: Activation of NF-kB mediates ICAM-1 induction in respiratory cells exposed to an adenovirus-derived vector.

Journal: Gene therapy 20010901

Title: 6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.

Journal: Biochemical pharmacology 20010815

Title: The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase.

Journal: Chemistry & biology 20010801

Title: Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: involvement of nuclear factor-kappaB.

Journal: Immunology letters 20010702

Title: Feverfew extracts and the sesquiterpene lactone parthenolide inhibit intercellular adhesion molecule-1 expression in human synovial fibroblasts.

Journal: Cellular immunology 20010501

Title: Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.

Journal: Oncogene 20010419

Title: A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation.

Journal: Planta medica 20010301

Title: Voltammetric determination of parthenolide in spiked human plasma and urine.

Journal: Phytochemical analysis : PCA 20010101

Title: A new sesquiterpene lactone from Tsoongiodendron odorum Chun.

Journal: Journal of Asian natural products research 20010101

Title: Augmentation of apoptosis responses in p53-deficient L1210 cells by compounds directed at blocking NFkappaB activation.

Journal: Anticancer research 20010101

Title: Antimycobacterial evaluation of germacranolides.

Journal: Phytochemistry 19980901

Title: Anti-inflammatory effects of South American Tanacetum vulgare.

Journal: The Journal of pharmacy and pharmacology 19980901

Title: Nakshatri H, et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22;6:e1608.

Title: Zhao X, et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3.

Title: Barbier-Torres L, et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62(4):1237-48.

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Tags:20554-84-1 Molecular Formula|20554-84-1 MDL|20554-84-1 SMILES|20554-84-1 Parthenolide