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208255-80-5,MFCD04974585
Catalog No.:AA002JIP

208255-80-5 | Dapt

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$23.00   $16.00
- +
10mg
98%
in stock  
$38.00   $26.00
- +
25mg
98%
in stock  
$73.00   $51.00
- +
100mg
98%
in stock  
$165.00   $115.00
- +
1g
98%
in stock  
$784.00   $549.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002JIP
Chemical Name:
Dapt
CAS Number:
208255-80-5
Molecular Formula:
C23H26F2N2O4
Molecular Weight:
432.4603
MDL Number:
MFCD04974585
SMILES:
O=C(N[C@H](C(=O)NC(c1ccccc1)C(=O)OC(C)(C)C)C)Cc1cc(F)cc(c1)F
Properties
Computed Properties
 
Complexity:
622  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
3.7  

Literature

Title: Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.

Journal: Bioorganic & medicinal chemistry letters 20110501

Title: Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.

Journal: Bioorganic & medicinal chemistry letters 20091215

Title: Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease.

Journal: Journal of medicinal chemistry 20081211

Title: Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

Journal: The Journal of biological chemistry 20071221

Title: Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Journal: The Journal of biological chemistry 20070824

Title: Dovey HF, et al. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem. 2001 Jan;76(1):173-81.

Title: Li S, et al. DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and nuclear factor κB in rats. Neurol Sci. 2012 Dec;33(6):1257-64.

Title: Zhou JX, et al. γ-secretase inhibition combined with NSC 119875 enhances apoptosis of nasopharyngeal carcinoma cells.Exp Ther Med. 2012 Feb;3(2):357-361.

Title: Tanimizu N, et al. Intrahepatic bile ducts are developed through formation of homogeneous continuous luminal network and its dynamic rearrangement in mice. Hepatology. 2016 Jul;64(1):175-88.

Title: Michael T. Chang, et al. Notch Drives Proliferation And Radiation Resistance Of Cancer Stem Cells In Adenoid Cystic Carcinoma. Yale University. January 2016.

Title: Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499.

Title: Yixin Tao, et al. β-catenin activation in hair follicle dermal stem cells induces ectopic hair outgrowth and skin fibrosis. J Mol Cell Biol. 2018 May 16.

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