Home Other Building Blocks 208260-29-1
208260-29-1,MFCD02683971
Catalog No.:AA002JJK

208260-29-1 | Zm 336372

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$12.00   $8.00
- +
5mg
98%
in stock  
$28.00   $19.00
- +
10mg
98%
in stock  
$43.00   $30.00
- +
50mg
98%
in stock  
$109.00   $76.00
- +
100mg
98%
in stock  
$172.00   $121.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002JJK
Chemical Name:
Zm 336372
CAS Number:
208260-29-1
Molecular Formula:
C23H23N3O3
Molecular Weight:
389.4470
MDL Number:
MFCD02683971
SMILES:
Oc1ccc(cc1)C(=O)Nc1cc(ccc1C)NC(=O)c1cccc(c1)N(C)C
Properties
Computed Properties
 
Complexity:
560  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
3.7  

Literature

Title: Mechanisms of the inhibition of nuclear factor-κB by morphine in neuronal cells.

Journal: Molecular pharmacology 20120401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines.

Journal: The Journal of surgical research 20100601

Title: ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line.

Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080501

Title: Pharmacophore identification of Raf-1 kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080401

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: The selectivity of protein kinase inhibitors: a further update.

Journal: The Biochemical journal 20071215

Title: Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways.

Journal: Surgery 20071201

Title: Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells.

Journal: Toxicology 20060921

Title: Rational design of inhibitors that bind to inactive kinase conformations.

Journal: Nature chemical biology 20060701

Title: ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells.

Journal: The Journal of surgical research 20060601

Title: Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation.

Journal: Free radical biology & medicine 20060315

Title: ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells.

Journal: Molecular cancer therapeutics 20050601

Title: A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: The specificities of protein kinase inhibitors: an update.

Journal: The Biochemical journal 20030401

Title: Hall-Jackson CA, et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol. 1999 Aug;6(8):559-68.

Title: Van Gompel JJ, et al. ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol Cancer Ther. 2005 Jun;4(6):910-7.

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SDS
Tags:208260-29-1 Molecular Formula|208260-29-1 MDL|208260-29-1 SMILES|208260-29-1 Zm 336372