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208848-19-5,MFCD09837826
Catalog No.:AA002JU8

208848-19-5 | Ono 6818

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$165.00   $115.00
- +
5mg
98%
in stock  
$397.00   $278.00
- +
10mg
98%
in stock  
$593.00   $415.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002JU8
Chemical Name:
Ono 6818
CAS Number:
208848-19-5
Molecular Formula:
C23H28N6O4
Molecular Weight:
452.5062
MDL Number:
MFCD09837826
SMILES:
O=C(Cn1c(ncc(c1=O)N)c1ccccc1)NC(C(=O)c1nnc(o1)C(C)(C)C)C(C)C
Properties
Computed Properties
 
Complexity:
825  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.6  

Literature

Title: AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.

Journal: The Journal of pharmacology and experimental therapeutics 20111001

Title: Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).

Journal: Comparative medicine 20050201

Title: Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.

Journal: The Journal of veterinary medical science 20041001

Title: ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation.

Journal: The Annals of thoracic surgery 20031001

Title: Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells.

Journal: The Journal of investigative dermatology 20010801

Title: Am J Respir Crit Care Med. 2002 Aug 15;166(4):496-500.

Title: K Ohmoto, et al. Design and synthesis of new orally active inhibitors of human neutrophil elastase. Bioorg Med Chem. 2001 May;9(5):1307-23.

Title: Yasushi Hirota, et al. Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J Vet Med Sci. 2004 Oct;66(10):1223-8.

Title: Yukihiro Yoshimura, et al. ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation. Ann Thorac Surg. 2003 Oct;76(4):1234-9.

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