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2095432-58-7,MFCD30187528
Catalog No.:AA01EO3J

2095432-58-7 | Sag hcl

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$13.00   $9.00
- +
5mg
98+%
in stock  
$29.00   $21.00
- +
10mg
98+%
in stock  
$45.00   $32.00
- +
25mg
98+%
in stock  
$74.00   $52.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EO3J
Chemical Name:
Sag hcl
CAS Number:
2095432-58-7
Molecular Formula:
C28H29Cl2N3OS
Molecular Weight:
526.5204
MDL Number:
MFCD30187528
SMILES:
CN[C@@H]1CC[C@H](CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1.Cl
Properties
Computed Properties
 
Complexity:
666  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  

Literature

Title: Chen JK, et al. Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

Title: Stanton BZ, et al. A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat Chem Biol. 2009 Mar;5(3):154-6.

Title: Guerrini G, et, al. Inhibition of smoothened in breast cancer cells reduces CAXII expression and cell migration. J Cell Physiol. 2018 Dec; 233(12): 9799-9811.

Title: Lee S, et al. Combining Smoothened Agonist (SAG) and NEL-like protein-1 (NELL-1) Enhances Bone Healing. Plast Reconstr Surg. 2017 Feb 13.

Title: Fish EW, et al. Preaxial polydactyly following early gestational exposure to the smoothened agonist, SAG, in C57BL/6J mice. Birth Defects Res A Clin Mol Teratol. 2016 Nov 1.

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Tags:2095432-58-7 Molecular Formula|2095432-58-7 MDL|2095432-58-7 SMILES|2095432-58-7 Sag hcl