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209860-87-7,MFCD08062150
Catalog No.:AA002KDH

209860-87-7 | Tafluprost

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Purity
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5mg
98%
in stock  
$129.00   $90.00
- +
25mg
98%
in stock  
$272.00   $190.00
- +
250mg
97%
in stock  
$384.00   $269.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002KDH
Chemical Name:
Tafluprost
CAS Number:
209860-87-7
Molecular Formula:
C25H34F2O5
Molecular Weight:
452.5313
MDL Number:
MFCD08062150
SMILES:
CC(OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/C(COc1ccccc1)(F)F)O)C
Properties
Computed Properties
 
Complexity:
614  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
13  
XLogP3:
4.5  

Literature

Title: Corneal epithelial cell viability following exposure to ophthalmic solutions containing preservatives and/or antihypertensive agents.

Journal: Advances in therapy 20121001

Title: Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.

Journal: Nanomedicine (London, England) 20120901

Title: Comparison of efficacy of four prostaglandin analogues by bilateral treatment in healthy subjects.

Journal: Japanese journal of ophthalmology 20120701

Title: Efficacy and ocular surface tolerability of preservative-free tafluprost 0.0015%: a 6-month, single-blind, observational study on naïve ocular hypertension or glaucoma patients.

Journal: Expert opinion on drug safety 20120701

Title: Randomized clinical trial of the efficacy and safety of preservative-free tafluprost and timolol in patients with open-angle glaucoma or ocular hypertension.

Journal: American journal of ophthalmology 20120601

Title: Spanish multicenter tafluprost tolerability study.

Journal: The British journal of ophthalmology 20120601

Title: Tafluprost (Zioptan) - a new topical prostaglandin for glaucoma.

Journal: The Medical letter on drugs and therapeutics 20120416

Title: In vitro study of antiadipogenic profile of latanoprost, travoprost, bimatoprost, and tafluprost in human orbital preadiopocytes.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20120401

Title: FDA approves glaucoma treatment.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120315

Title: Ocular hypotensive effect of tafluprost in latanoprost low-responder cynomolgus monkeys.

Journal: Journal of glaucoma 20120201

Title: A prospective study evaluating IOP changes after switching from a therapy with prostaglandin eye drops containing preservatives to nonpreserved tafluprost in glaucoma patients.

Journal: TheScientificWorldJournal 20120101

Title: Clobazam, ezogabine, and tafluprost.

Journal: Journal of the American Pharmacists Association : JAPhA 20120101

Title: Efficacy and safety of tafluprost in normal-tension glaucoma with intraocular pressure of 16 mmHg or less.

Journal: Japanese journal of ophthalmology 20111101

Title: Tafluprost for glaucoma.

Journal: Expert opinion on pharmacotherapy 20111001

Title: Tafluprost: a novel prostaglandin analog for treatment of glaucoma.

Journal: Advances in therapy 20110901

Title: Preservative-free tafluprost 0.0015% in the treatment of patients with glaucoma and ocular hypertension.

Journal: Advances in therapy 20110701

Title: Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system.

Journal: The British journal of ophthalmology 20110601

Title: Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110601

Title: Effects of prostaglandin F(2α) analogues on endothelin-1-induced impairment of rabbit ocular blood flow: comparison among tafluprost, travoprost, and latanoprost.

Journal: Experimental eye research 20101201

Title: Effects of benzalkonium chloride-preserved, polyquad-preserved, and sofZia-preserved topical glaucoma medications on human ocular epithelial cells.

Journal: Advances in therapy 20101101

Title: Effects of topical phenylephrine and tafluprost on optic nerve head circulation in monkeys with unilateral experimental glaucoma.

Journal: Investigative ophthalmology & visual science 20100801

Title: IOP-lowering efficacy and tolerability of preservative-free tafluprost 0.0015% among patients with ocular hypertension or glaucoma.

Journal: Current medical research and opinion 20100801

Title: Twenty-four-hour ocular hypotensive effects of 0.0015% tafluprost and 0.005% latanoprost in healthy subjects.

Journal: Japanese journal of ophthalmology 20100701

Title: [Optimization of benzalkonium chloride concentration in 0.0015% tafluprost ophthalmic solution from the points of ocular surface safety and preservative efficacy].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100601

Title: In vitro toxicity of topical ocular prostaglandin analogs and preservatives on corneal epithelial cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100601

Title: A review of preserved and preservative-free prostaglandin analogues for the treatment of open-angle glaucoma and ocular hypertension.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100601

Title: [Intraocular pressure lowering effect of 0.0015% tafluprost as compared to placebo in patients with normal tension glaucoma: randomized, double-blind, multicenter, phase III study].

Journal: Nippon Ganka Gakkai zasshi 20100501

Title: Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication.

Journal: Acta ophthalmologica 20100501

Title: Effects of repeated administrations of tafluprost, latanoprost, and travoprost on optic nerve head blood flow in conscious normal rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100401

Title: A phase II study on the duration and stability of the intraocular pressure-lowering effect and tolerability of Tafluprost compared with latanoprost.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20100201

Title: Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study.

Journal: Acta ophthalmologica 20100201

Title: Tafluprost protects rat retinal ganglion cells from apoptosis in vitro and in vivo.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20091001

Title: Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090801

Title: Corneal penetration into rabbit aqueous humor is comparable between preserved and preservative-free tafluprost.

Journal: Ophthalmic research 20090101

Title: Adjunctive use of tafluprost with timolol provides additive effects for reduction of intraocular pressure in patients with glaucoma.

Journal: European journal of ophthalmology 20090101

Title: [Receptors involved in the mechanism of action of topical prostaglandines].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20090101

Title: Short-term effects of topical tafluprost on retinal blood flow in cats.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081001

Title: Relaxing effect and mechanism of tafluprost on isolated rabbit ciliary arteries.

Journal: Experimental eye research 20080901

Title: Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride.

Journal: The British journal of ophthalmology 20080901

Title: Tafluprost, a new potent prostanoid receptor agonist: a dose-response study on pharmacodynamics and tolerability in healthy volunteers.

Journal: International journal of clinical pharmacology and therapeutics 20080801

Title: In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line.

Journal: Current eye research 20080401

Title: In search of improved prostaglandin treatment for glaucoma.

Journal: Acta ophthalmologica. Supplement 20080101

Title: Pharmacokinetics, efficacy and safety profiles of preserved and preservative-free tafluprost in healthy volunteers.

Journal: Acta ophthalmologica. Supplement 20080101

Title: Efficacy and safety levels of preserved and preservative-free tafluprost are equivalent in patients with glaucoma or ocular hypertension: results from a pharmacodynamics analysis.

Journal: Acta ophthalmologica. Supplement 20080101

Title: [Glaucoma--strategy of treatment].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20080101

Title: A comparative, placebo-controlled study of prostanoid fluoroprostaglandin-receptor agonists tafluprost and latanoprost in healthy males.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801

Title: The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice.

Journal: The British journal of ophthalmology 20070501

Title: Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation.

Journal: Investigative ophthalmology & visual science 20050601

Title: Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug.

Journal: Experimental eye research 20040401

Title: New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents.

Journal: Biological & pharmaceutical bulletin 20031201

Title: Kuwayama, Y. and A. Nomura, Prospective observational post-marketing study of tafluprost for glaucoma and ocular hypertension: short-term efficacy and safety. Adv Ther, 2014. 31(4): p. 461-71.

Title: Kumagami, T., et al., Comparison of corneal safety and intraocular pressure-lowering effect of tafluprost ophthalmic solution with other prostaglandin ophthalmic solutions. J Ocul Pharmacol Ther, 2014. 30(4): p. 340-5.

Title: Inoue, K., A. Tanaka, and G. Tomita, Effects of tafluprost treatment for 3 years in patients with normal-tension glaucoma. Clin Ophthalmol, 2013. 7: p. 1411-6.

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