Home Fluorides 209984-56-5
209984-56-5,MFCD12828734
Catalog No.:AA002KFG

209984-56-5 | (S)-2-(2-(3,5-Difluorophenyl)acetamido)-n-((s)-5-methyl-6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl)propanamide

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1mg
≥98%
in stock  
$46.00   $32.00
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2mg
95%
in stock  
$84.00   $59.00
- +
5mg
≥98%
in stock  
$90.00   $63.00
- +
10mg
≥98%
in stock  
$133.00   $93.00
- +
50mg
95%
in stock  
$525.00   $368.00
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250mg
95%
in stock  
$887.00   $621.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002KFG
Chemical Name:
(S)-2-(2-(3,5-Difluorophenyl)acetamido)-n-((s)-5-methyl-6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl)propanamide
CAS Number:
209984-56-5
Molecular Formula:
C26H23F2N3O3
Molecular Weight:
463.4759
MDL Number:
MFCD12828734
SMILES:
Fc1cc(cc(c1)F)CC(=O)N[C@H](C(=O)N[C@H]1c2ccccc2c2c(N(C1=O)C)cccc2)C
Properties
Computed Properties
 
Complexity:
756  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.6  

Downstream Synthesis Route
7-amino-5-methyl-5H-dibenzob,dazepin-6(7H)-onehydrochloride 
  208124-34-9    209984-56-5 

[1]CurrentPatentAssignee:PERRIGOCOMPANYPUBLICLIMITEDCOMPANY;ELILILLY&CO-EP951466,2009,B1Locationinpatent:Page/Pagecolumn62;79

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74.

Title: Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18.

Title: Zheng YH, et al. Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms. PLoS One. 2013 Dec 16;8(12):e83310.

Title: Xiao Z, et al. The Notch γ-secretase inhibitor ameliorates kidney fibrosis via inhibition of TGF-β/Smad2/3 signaling pathway activation. Int J Biochem Cell Biol. 2014 Oct;55:65-71.

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SDS
Tags:209984-56-5 Molecular Formula|209984-56-5 MDL|209984-56-5 SMILES|209984-56-5 (S)-2-(2-(3,5-Difluorophenyl)acetamido)-n-((s)-5-methyl-6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl)propanamide