Catalog No.:AA00BE8C

209986-17-4 | γ-Secretase Inhibitor XXI

Name: Name:γ-Secretase Inhibitor XXI
Brand: AABLOCKS
SKU: AA00BE8C
Rating: 90 (10 reviews)

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA00BE8C

Chemical Name:

γ-Secretase Inhibitor XXI

CAS Number:

209986-17-4

Molecular Formula:

C27H24F2N4O3

Molecular Weight:

490.5013

MDL Number:

MFCD04974531

SMILES:

Fc1cc(cc(c1)F)CC(=O)N[C@H](C(=O)N[C@H]1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2)C

Properties

Computed Properties

Complexity:

837

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

3.6

Downstream Synthesis Route

Literature

Title: Recent advances in the identification of gamma-secretase inhibitors to clinically test the Abeta oligomer hypothesis of Alzheimer's disease.

Journal: Journal of medicinal chemistry 20091022

Title: Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402.

Title: Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88.

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SDS