Title: Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands.
Journal: Molecular pharmacology 20070301
Title: Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity.
Journal: Molecular pharmacology 20060701
Title: Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors.
Journal: Journal of medicinal chemistry 20060112
Title: Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20060101
Title: Allosteric modulators and selective agonists of muscarinic receptors.
Journal: Journal of molecular neuroscience : MN 20060101
Title: Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide.
Journal: Molecular pharmacology 20050901
Title: Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.
Journal: Journal of medicinal chemistry 20040603
Title: Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding.
Journal: Journal of medicinal chemistry 20030313
