Catalog No.:AA01KFDE

2114339-57-8 | 8-(2,4-Dichlorophenyl)-9-[4-[[(3S)-1-(3-fluoropropyl)-3-pyrrolidinyl]oxy]phenyl]-6,7-dihydro-5H-benzocycloheptene-3-carboxylic acid

Name: Name:8-(2,4-Dichlorophenyl)-9-[4-[[(3S)-1-(3-fluoropropyl)-3-pyrrolidinyl]oxy]phenyl]-6,7-dihydro-5H-benzocycloheptene-3-carboxylic acid
Brand: AABLOCKS
SKU: AA01KFDE
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10mg

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA01KFDE

Chemical Name:

8-(2,4-Dichlorophenyl)-9-[4-[[(3S)-1-(3-fluoropropyl)-3-pyrrolidinyl]oxy]phenyl]-6,7-dihydro-5H-benzocycloheptene-3-carboxylic acid

CAS Number:

2114339-57-8

Molecular Formula:

C31H30Cl2FNO3

Molecular Weight:

554.4792

SMILES:

O=C(C1=CC=C(C(C3=CC=C(O[C@@H]4CN(CCCF)CC4)C=C3)=C(C5=CC=C(Cl)C=C5Cl)CCC2)C2=C1)O

Properties

Downstream Synthesis Route

2114341-34-1

2114339-57-8

[1]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[2]CurrentPatentAssignee:SANOFI-EP3434272,2019,A1

[3]El-Ahmad,Youssef;Tabart,Michel;Halley,Frank;Certal,Victor;Thompson,Fabienne;Filoche-Rommé,Bruno;Gruss-Leleu,Florence;Muller,Claire;Brollo,Maurice;Fabien,Laurence;Loyau,Véronique;Bertin,Luc;Richepin,Patrick;Pilorge,Fabienne;Desmazeau,Pascal;Girardet,Chrystelle;Beccari,Sylvie;Louboutin,Audrey;Lebourg,Gilles;Le-Roux,Jacques;Terrier,Corinne;Vallée,François;Steier,Valérie;Mathieu,Magali;Rak,Alexey;Abecassis,Pierre-Yves;Vicat,Pascale;Benard,Tsiala;Bouaboula,Monsif;Sun,Fangxian;Shomali,Maysoun;Hebert,Andrew;Levit,Mikhail;Cheng,Hong;Courjaud,Albane;Ginesty,Celine;Perrault,Christelle;Garcia-Echeverria,Carlos;McCort,Gary;Schio,Laurent[JournalofMedicinalChemistry,2020,vol.63,#2,p.512-528]

2114341-28-3

2114339-57-8

[1]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[2]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[3]CurrentPatentAssignee:SANOFI-EP3434272,2019,A1

[4]CurrentPatentAssignee:SANOFI-EP3434272,2019,A1

[5]El-Ahmad,Youssef;Tabart,Michel;Halley,Frank;Certal,Victor;Thompson,Fabienne;Filoche-Rommé,Bruno;Gruss-Leleu,Florence;Muller,Claire;Brollo,Maurice;Fabien,Laurence;Loyau,Véronique;Bertin,Luc;Richepin,Patrick;Pilorge,Fabienne;Desmazeau,Pascal;Girardet,Chrystelle;Beccari,Sylvie;Louboutin,Audrey;Lebourg,Gilles;Le-Roux,Jacques;Terrier,Corinne;Vallée,François;Steier,Valérie;Mathieu,Magali;Rak,Alexey;Abecassis,Pierre-Yves;Vicat,Pascale;Benard,Tsiala;Bouaboula,Monsif;Sun,Fangxian;Shomali,Maysoun;Hebert,Andrew;Levit,Mikhail;Cheng,Hong;Courjaud,Albane;Ginesty,Celine;Perrault,Christelle;Garcia-Echeverria,Carlos;McCort,Gary;Schio,Laurent[JournalofMedicinalChemistry,2020,vol.63,#2,p.512-528]

6500-65-8

2114339-57-8

[1]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[2]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

3470-51-7

2114339-57-8

[1]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[2]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[3]CurrentPatentAssignee:SANOFI-EP3434272,2019,A1

[4]CurrentPatentAssignee:SANOFI-EP3434272,2019,A1

2114341-33-0

2114339-57-8

[1]CurrentPatentAssignee:SANOFI-US9714221,2017,B1

[2]CurrentPatentAssignee:SANOFI-EP3434272,2019,A1

Literature

Title: El-Ahmad Y, et al. Discovery of 6-(2,4-Dichlorophenyl)-5--[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yloxyphenyl-8,9-dihydro-7H-benzoannulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J Med Chem. 2019 Nov 27.

Title: Monsif Bouaboula, et al. Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer.

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