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212631-67-9,MFCD16038897
Catalog No.:AA006XZ9

212631-67-9 | PD 184161

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1mg
≥98%
in stock  
$40.00   $28.00
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5mg
≥98%
in stock  
$168.00   $117.00
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10mg
≥98%
in stock  
$296.00   $207.00
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25mg
≥98%
in stock  
$640.00   $448.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006XZ9
Chemical Name:
PD 184161
CAS Number:
212631-67-9
Molecular Formula:
C17H13BrClF2IN2O2
Molecular Weight:
557.5556
MDL Number:
MFCD16038897
SMILES:
Ic1ccc(c(c1)Cl)Nc1c(cc(c(c1F)F)Br)C(=O)NOCC1CC1
Properties
Computed Properties
 
Complexity:
505  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
6.3  

Literature

Title: nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11β-HSD2.

Journal: Toxicology and applied pharmacology 20180401

Title: IGF1/MAPK/ERK signaling pathway-mediated programming alterations of adrenal cortex cell proliferation by prenatal caffeine exposure in male offspring rats.

Journal: Toxicology and applied pharmacology 20180215

Title: Melanoma Expressed-CD70 Is Regulated by RhoA and MAPK Pathways without Affecting Vemurafenib Treatment Activity.

Journal: PloS one 20160101

Title: Cadmium promotes the proliferation of triple-negative breast cancer cells through EGFR-mediated cell cycle regulation.

Journal: Toxicology and applied pharmacology 20151115

Title: Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells.

Journal: Toxicology and applied pharmacology 20150815

Title: Antidepressant-like effect of sildenafil through oxytocin-dependent cyclic AMP response element-binding protein phosphorylation.

Journal: Neuroscience 20120103

Title: Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation.

Journal: Experimental hematology 20091001

Title: Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Journal: The Journal of pharmacology and experimental therapeutics 20090601

Title: The effect of doxorubicin on MEK-ERK signaling predicts its efficacy in HCC.

Journal: The Journal of surgical research 20081201

Title: A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment.

Journal: Biological psychiatry 20070301

Title: The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.

Journal: Neoplasia (New York, N.Y.) 20060101

Title: Aggravation of necrotic death of glucose-deprived cells by the MEK1 inhibitors U0126 and PD184161 through depletion of ATP.

Journal: Biochemical pharmacology 20040715

Title: Prolonged extracellular signal-regulated kinase 1/2 activation during fibroblast growth factor 1- or heregulin beta1-induced antiestrogen-resistant growth of breast cancer cells is resistant to mitogen-activated protein/extracellular regulated kinase kinase inhibitors.

Journal: Cancer research 20040701

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