Catalog No.:AA00BHR9

214287-99-7 | (4S)-6-CHLORO-4-((E)-2-CYCLOPROPYLVINYL)-4-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE

Name: Name:(4S)-6-CHLORO-4-((E)-2-CYCLOPROPYLVINYL)-4-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
Brand: AABLOCKS
SKU: AA00BHR9
Availability: InStock
Rating: 90 (10 reviews)

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2.5mg

2 weeks

$1,113.00 $779.00

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25mg

2 weeks

$3,817.00 $2,672.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00BHR9

Chemical Name:

(4S)-6-CHLORO-4-((E)-2-CYCLOPROPYLVINYL)-4-(TRIFLUOROMETHYL)-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE

CAS Number:

214287-99-7

Molecular Formula:

C14H12ClF3N2O

Molecular Weight:

316.7061

MDL Number:

MFCD26960895

SMILES:

C1CC1C=CC2(C3=C(C=CC(=C3)Cl)NC(=O)N2)C(F)(F)F

Properties

Form:

Solid

MP:

124 - 126°C

Storage:

Light sensitive;-20 ℃;Inert atmosphere;

Computed Properties

Complexity:

464

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

3.7

Literature

Title: Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.

Journal: Bioorganic & medicinal chemistry 20100715

Title: QSAR for non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Journal: Bioorganic & medicinal chemistry 20060901

Title: Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors.

Journal: Current topics in medicinal chemistry 20040101

Title: General scope of 1,4-diastereoselective additions to a 2(3H)-quinazolinone: practical preparation of HIV therapeutics.

Journal: The Journal of organic chemistry 20030207

Title: Potency of nonnucleoside reverse transcriptase inhibitors (NNRTIs) used in combination with other human immunodeficiency virus NNRTIs, NRTIs, or protease inhibitors.

Journal: Antimicrobial agents and chemotherapy 20020601

Title: DPC-083. DuPont Pharmaceuticals.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010901

Title: 4,1-Benzoxazepinone analogues of efavirenz (Sustiva) as HIV-1 reverse transcriptase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20010604

Title: New antiretroviral agents.

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20010301

Title: Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase.

Journal: Bioorganic & medicinal chemistry letters 20010212

Title: 3,3a-Dihydropyrano[4,3,2-de]quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20010122

Title: Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors.

Journal: Journal of medicinal chemistry 20000518

Title: Expanded-spectrum nonnucleoside reverse transcriptase inhibitors inhibit clinically relevant mutant variants of human immunodeficiency virus type 1.

Journal: Antimicrobial agents and chemotherapy 19991201

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