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21436-03-3,MFCD00062986
Catalog No.:AA003BFT

21436-03-3 | (1S,2S)-(+)-1,2-Diaminocyclohexane

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250mg
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1g
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5g
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10g
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25g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003BFT
Chemical Name:
(1S,2S)-(+)-1,2-Diaminocyclohexane
CAS Number:
21436-03-3
Molecular Formula:
C6H14N2
Molecular Weight:
114.1888
MDL Number:
MFCD00062986
SMILES:
N[C@H]1CCCC[C@@H]1N
Properties
Properties
 
BP:
104-110°C at 40 mmHg  
Form:
Solid  
MP:
40-43 °C(lit.);  
Refractive Index:
1.4886  
Stability:
Air Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
62.9  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
-0.3  

Literature

Title: A new 'fully reduced' polyoxovanadate constructed from nanosized triangle-shaped [V(III)3V(IV)18P6O60(DACH)3]}9- cluster anions exhibiting ferrimagnetic interactions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20120917

Title: Antitumor platinum(II) complexes of N-monoalkyl-1R, 2R-diaminocyclohexane derivatives with alkyl groups as hindrance.

Journal: Journal of inorganic biochemistry 20120701

Title: Stereoselective UV sensing of 1,2-diaminocyclohexane isomers based on ligand displacement with a diacridylnaphthalene N,N'-dioxide scandium complex.

Journal: The Journal of organic chemistry 20120601

Title: Diastereoselective imine-bond formation through complementary double-helix formation.

Journal: Journal of the American Chemical Society 20120502

Title: Synthesis, in vitro cytotoxicity, and interaction with DNA of platinum(II) complexes with N-monocycloalkyl derivatives of 1R,2R-diaminocyclohexane as carrier ligands.

Journal: ChemMedChem 20120401

Title: trans-1,2-Diaminocyclohexane mesoporous silica for asymmetric catalysis: enhancement of chirality through confinement space by the plug effect.

Journal: Chemical communications (Cambridge, England) 20120325

Title: Controlling the macrocycle size by the stoichiometry of the applied template ion.

Journal: Chemical communications (Cambridge, England) 20120221

Title: Trinuclear Cu(II) complexes of a chiral N6O3 amine.

Journal: Dalton transactions (Cambridge, England : 2003) 20120207

Title: Steric modifications tune the regioselectivity of the alkane oxidation catalyzed by non-heme iron complexes.

Journal: Inorganic chemistry 20111219

Title: Interactions of an asymmetric amine with a non-C2 symmetric Cu-salen complex: an EPR/ENDOR and HYSCORE investigation.

Journal: Physical chemistry chemical physics : PCCP 20111207

Title: Chiral diaminopyrrolic receptors for selective recognition of mannosides, part 1: design, synthesis, and affinities of second-generation tripodal receptors.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110418

Title: A mechanistic approach for the DNA binding of chiral enantiomeric L- and D-tryptophan-derived metal complexes of 1,2-DACH: cleavage and antitumor activity.

Journal: Chirality 20110301

Title: Oligopyrenotides: abiotic, polyanionic oligomers with nucleic acid-like structural properties.

Journal: Journal of the American Chemical Society 20100602

Title: Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: exploration of 5-6 fused rings as alternative S1 moieties.

Journal: Bioorganic & medicinal chemistry 20091215

Title: Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.

Journal: Bioorganic & medicinal chemistry 20091215

Title: Synthesis, spectroscopic, structural characterization, electrochemical and antimicrobial activity studies of the Schiff base ligand and its transition metal complexes.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091015

Title: Trinuclear C3-symmetric extension of Jacobsen's catalyst: synthesis, characterization, and catalytic properties of a chiral trinuclear Mn(III) triplesalen complex.

Journal: Inorganic chemistry 20091005

Title: Critical role of external axial ligands in chirality amplification of trans-cyclohexane-1,2-diamine in salen complexes.

Journal: Journal of the American Chemical Society 20090902

Title: Quantification of trace elements in natural samples by electrospray ionization mass spectrometry with a size-exclusion column based on the formation of metal-aminopolycarboxylate complexes.

Journal: Analytical chemistry 20090801

Title: Simple cyclohexanediamine-derived primary amine thiourea catalyzed highly enantioselective conjugate addition of nitroalkanes to enones.

Journal: Organic letters 20090702

Title: Synthesis, characterization, and application of vanadium-salan complexes in oxygen transfer reactions.

Journal: Inorganic chemistry 20090420

Title: Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.

Journal: Bioorganic & medicinal chemistry 20080801

Title: Instantaneous low temperature gelation by a multicomponent organogelator liquid system based on ammonium salts.

Journal: Journal of the American Chemical Society 20080625

Title: Trans-cyclohexanediamines prevent thermal inactivation of protein: role of hydrophobic and electrostatic interactions.

Journal: The protein journal 20080601

Title: (1Z,1'Z,3E,3'E)-1,1'-Diphenyl-3,3'-[(1S,2S)-cyclo-hexane-1,2-diyldinitrilo]dibut-1-en-1-ol.

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: Discrimination of enantiomers of alpha-amino acids by chiral derivatizing reagents from trans-1,2-diaminocyclohexane.

Journal: Chirality 20080301

Title: Unique properties of DNA interstrand cross-links of antitumor oxaliplatin and the effect of chirality of the carrier ligand.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Title: Dinuclear platinum complexes with biological relevance based on the 1,2-diaminocyclohexane carrier ligand.

Journal: Inorganic chemistry 20070723

Title: Enantioselective fluorescent recognition of chiral acids by cyclohexane-1,2-diamine-based bisbinaphthyl molecules.

Journal: The Journal of organic chemistry 20070622

Title: The impact of different chelating leaving groups on the substitution kinetics of mononuclear Pt(II)(1,2-trans-R,R-diaminocyclohexane)(X-Y) complexes.

Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070501

Title: A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?

Journal: ChemMedChem 20070401

Title: Asymmetric amplification in catalysis by trans-1,2-diaminocyclohexane bistriflamide.

Journal: Organic letters 20070118

Title: Review of the toxicology of three alkyl diamines.

Journal: Drug and chemical toxicology 20070101

Title: Chiral macrocyclic aliphatic oligoimines derived from trans-1,2-diaminocyclohexane.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

Title: Flexibility of inorganic tennis ball structures inducing anion selectivity.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060918

Title: Asymmetric transfer hydrogenation catalysed by hydrophobic dendritic DACH-rhodium complex in water.

Journal: Organic & biomolecular chemistry 20060907

Title: Luminescent amidate-bridged one-dimensional platinum(II)-thallium(I) coordination polymers assembled via metallophilic attraction.

Journal: Inorganic chemistry 20060710

Title: Racemic N-aryl bis(amidines) and bis(amidinates): on the trail of enantioselective organolanthanide catalysts.

Journal: Dalton transactions (Cambridge, England : 2003) 20060328

Title: Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane.

Journal: Bioorganic & medicinal chemistry letters 20060315

Title: Determination of different classes of amines with capillary zone electrophoresis and contactless conductivity detection.

Journal: Electrophoresis 20060201

Title: Lanthanide complexes of chiral 3 + 3 macrocycles derived from (1R,2R)-1,2-diaminocyclohexane and 2,6-diformyl-4-methylphenol.

Journal: Dalton transactions (Cambridge, England : 2003) 20060114

Title: Rhombimines-cyclic tetraimines of trans-1,2-diaminocyclohexane shaped by the diaryl ether structural motif.

Journal: The Journal of organic chemistry 20051125

Title: New 2+2, 3+3 and 4+4 macrocycles derived from 1,2-diaminocyclohexane and 2,6-diformylpyridine.

Journal: Organic & biomolecular chemistry 20050907

Title: Colorimetric enantiodiscrimination of alpha-amino acids in protic media.

Journal: Journal of the American Chemical Society 20050608

Title: Shape-complementarity in the recognition of tricarboxylic acids by a [3+3] polyazacyclophane receptor.

Journal: The Journal of organic chemistry 20050318

Title: Chromatographic evaluation of poly (trans-1,2-cyclohexanediyl-bis acrylamide) as a chiral stationary phase for HPLC.

Journal: Journal of chromatography. A 20050225

Title: Kinetic resolution of amines: a highly enantioselective and chemoselective acetylating agent with a unique solvent-induced reversal of stereoselectivity.

Journal: Angewandte Chemie (International ed. in English) 20040621

Title: Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability.

Journal: European journal of medicinal chemistry 20040501

Title: X-ray structure and circular dichroism of pure rotamers of bis[guanosine-5'-monophosphate(-1)](N,N,N',N'-tetramethylcyclohexyl-1,2-diamine)platinum(II) complexes that have R,R and S,S configurations at the asymmetric diamine.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20031215

Title: Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand.

Journal: Journal of medicinal chemistry 20031106

Title: A metal-centered hydrophobic pocket recognizing pyridine over piperidine.

Journal: Journal of the American Chemical Society 20030618

Title: Nitrogen lone pair interactions in organic molecules: a photoelectron spectroscopic study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601

Title: Synthesis, characterization and preliminary cytotoxicity assays of poly(ethylene glycol)-malonato-Pt-DACH conjugates.

Journal: European journal of medicinal chemistry 20030101

Title: Occupational contact sensitization to 1,2-diaminocyclohexane.

Journal: Contact dermatitis 20010801

Title: The in vitro antitumour profile of some 1,2-diaminocyclohexane organotin complexes.

Journal: Journal of inorganic biochemistry 20010115

Title: [Oxaliplatin: preclinical in vitro studies].

Journal: Tumori 20010101

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Tags:21436-03-3 Molecular Formula|21436-03-3 MDL|21436-03-3 SMILES|21436-03-3 (1S,2S)-(+)-1,2-Diaminocyclohexane |Organic_Building_Blocks