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21498-08-8,MFCD00917022
Catalog No.:AA00I437

21498-08-8 | Lofexidine hydrochloride

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250mg
≥98%
in stock  
$58.00   $40.00
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500mg
≥98%
in stock  
$92.00   $64.00
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1g
≥98%
in stock  
$136.00   $95.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I437
Chemical Name:
Lofexidine hydrochloride
CAS Number:
21498-08-8
Molecular Formula:
C11H13Cl3N2O
Molecular Weight:
295.5927
MDL Number:
MFCD00917022
SMILES:
CC(C1=NCCN1)Oc1c(Cl)cccc1Cl.Cl
NSC Number:
759654
Properties
Computed Properties
 
Complexity:
263  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Outpatient versus inpatient opioid detoxification: a randomized controlled trial.

Journal: Journal of substance abuse treatment 20110101

Title: The pharmacological treatment of opioid addiction--a clinical perspective.

Journal: European journal of clinical pharmacology 20100601

Title: A comparison of methadone, buprenorphine and alpha(2) adrenergic agonists for opioid detoxification: a mixed treatment comparison meta-analysis.

Journal: Drug and alcohol dependence 20100401

Title: Lofexidine, an {alpha}2-receptor agonist for opioid detoxification.

Journal: The Annals of pharmacotherapy 20100201

Title: Buprenorphine for the management of opioid withdrawal.

Journal: The Cochrane database of systematic reviews 20090708

Title: Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study.

Journal: Pharmacotherapy 20090501

Title: Pharmacokinetics of lofexidine hydrochloride in healthy volunteers.

Journal: Journal of pharmaceutical sciences 20090101

Title: Urine and plasma pharmacokinetics of lofexidine after oral delivery in opiate-dependent patients.

Journal: The American journal of drug and alcohol abuse 20090101

Title: A study on Fu-Yuan Pellet, a traditional chinese medicine formula for detoxification of heroin addictions.

Journal: The American journal of drug and alcohol abuse 20090101

Title: A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal.

Journal: Drug and alcohol dependence 20080901

Title: Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse.

Journal: Psychopharmacology 20080301

Title: Tai-Kang-Ning, a Chinese herbal medicine formula, alleviates acute heroin withdrawal.

Journal: The American journal of drug and alcohol abuse 20080101

Title: Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic receptor agonist, in opiate addicts plasma using a highly sensitive liquid chromatography tandem mass spectrometric analysis.

Journal: The American journal of drug and alcohol abuse 20080101

Title: A comparative clinical study of the effects of the traditional Chinese medicine Jinniu capsules and lofexidine on acute heroin withdrawal symptoms.

Journal: The American journal of drug and alcohol abuse 20080101

Title: Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study.

Journal: Pharmacotherapy 20070801

Title: In-patient detoxification procedures, treatment retention, and post-treatment opiate use: comparison of lofexidine + naloxone, lofexidine + placebo, and methadone.

Journal: Drug and alcohol dependence 20070417

Title: Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings.

Journal: Psychopharmacology 20070301

Title: Opiate addiction in China: current situation and treatments.

Journal: Addiction (Abingdon, England) 20060501

Title: Opioid antagonists with minimal sedation for opioid withdrawal.

Journal: The Cochrane database of systematic reviews 20060125

Title: A comparison of buprenorphine and lofexidine for community opiate detoxification: results from a randomized controlled trial.

Journal: Addiction (Abingdon, England) 20051201

Title: Induction of patients with moderately severe methadone dependence onto buprenorphine.

Journal: Addiction biology 20050601

Title: Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats.

Journal: Psychopharmacology 20050501

Title: QT interval increased after single dose of lofexidine.

Journal: BMJ (Clinical research ed.) 20041106

Title: [Clinical observation on effect of modified banxia houpu decoction in treating patients with protracted heroin abstinence syndrome].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040301

Title: Evaluation of the effects of lofexidine and clonidine on naloxone-precipitated withdrawal in opioid-dependent humans.

Journal: Addiction (Abingdon, England) 20030401

Title: A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.

Journal: Journal of psychopharmacology (Oxford, England) 20030301

Title: Major disruptions of sleep during treatment of the opiate withdrawal syndrome: differences between methadone and lofexidine detoxification treatments.

Journal: Addiction biology 20030301

Title: The effectiveness of combined naloxone/lofexidine in opiate detoxification: results from a double-blind randomized and placebo-controlled trial.

Journal: The American journal on addictions 20030101

Title: Lofexidine in hyperactive and impulsive children with autistic disorder.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry 20021201

Title: Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone.

Journal: Drug and alcohol dependence 20020701

Title: Use of qigong therapy in the detoxification of heroin addicts.

Journal: Alternative therapies in health and medicine 20020101

Title: Alpha2-adrenergic agonists in opioid withdrawal.

Journal: Addiction (Abingdon, England) 20020101

Title: Two methods of community detoxification from opiates: an open-label comparison of lofexidine and buprenorphine.

Journal: Drug and alcohol dependence 20011201

Title: Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010901

Title: Randomized placebo controlled trial of lofexidine hydrochloride for chronic pelvic pain in women.

Journal: Human reproduction (Oxford, England) 20010801

Title: Lofexidine versus clonidine in rapid opiate detoxification.

Journal: Journal of substance abuse treatment 20010701

Title: A double-blind randomized placebo-controlled trial of lofexidine in alcohol withdrawal: lofexidine is not a useful adjunct to chlordiazepoxide.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20010101

Title: [Therapy of tic disorders apparently of organic origin in a multi-morbid 5-year-old patient with lofexidine (Britlofex) and clonidine (Catapressan)].

Journal: Wiener medizinische Wochenschrift (1946) 20010101

Title: Alpha-2 adrenergic receptor agonists block stress-induced reinstatement of cocaine seeking.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20000801

Title: Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.

Journal: Drug and alcohol dependence 19980501

Title: Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal.

Journal: Drug and alcohol dependence 19971125

Title: Alcohol withdrawal syndromes: clinical management with lofexidine.

Journal: Alcoholism, clinical and experimental research 19850101

Title: Animal experiments on the safety pharmacology of lofexidine.

Journal: Arzneimittel-Forschung 19820101

Title: Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9(11):1371-7.

Title: Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44(2):343-51.

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