Home Other Building Blocks 215923-54-9
215923-54-9,MFCD01860868
Catalog No.:AA00BF32

215923-54-9 | (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98+%
in stock  
$45.00   $32.00
- +
25mg
98+%
in stock  
$76.00   $54.00
- +
50mg
98+%
in stock  
$106.00   $75.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF32
Chemical Name:
(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone
CAS Number:
215923-54-9
Molecular Formula:
C14H17NO3
Molecular Weight:
247.2897
MDL Number:
MFCD01860868
SMILES:
O=C(c1ccc2c(c1)OCCO2)N1CCCCC1
Properties
Computed Properties
 
Complexity:
301  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
1.1  

Literature

Title: Excessive novelty-induced c-Fos expression and altered neurogenesis in the hippocampus of GluA1 knockout mice.

Journal: The European journal of neuroscience 20110101

Title: AMPA receptor mediates mGlu 2/3 receptor antagonist-induced dopamine release in the rat nucleus accumbens shell.

Journal: Neurochemistry international 20101101

Title: Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Journal: Journal of medicinal chemistry 20101028

Title: Effects of agents targeting glutamatergic systems on marble-burying behavior.

Journal: Neuroscience letters 20100303

Title: Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats.

Journal: Behavioural brain research 20100211

Title: Modulation of agonist binding to AMPA receptors by 1-(1,4-benzodioxan-6-ylcarbonyl)piperidine (CX546): differential effects across brain regions and GluA1-4/transmembrane AMPA receptor regulatory protein combinations.

Journal: The Journal of pharmacology and experimental therapeutics 20091201

Title: Memory and the NMDA receptors.

Journal: The New England journal of medicine 20090716

Title: Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.

Journal: PLoS biology 20090201

Title: Breathing dysfunction in Rett syndrome: understanding epigenetic regulation of the respiratory network.

Journal: Respiratory physiology & neurobiology 20081210

Title: Central respiratory rhythmogenesis is abnormal in lbx1- deficient mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081022

Title: Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats.

Journal: European journal of pharmacology 20071201

Title: Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20071003

Title: The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

Title: Ampakines alleviate respiratory depression in rats.

Journal: American journal of respiratory and critical care medicine 20061215

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Glutamate-based therapeutic approaches: ampakines.

Journal: Current opinion in pharmacology 20060201

Title: Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus.

Journal: The Journal of pharmacology and experimental therapeutics 20050401

Title: Ampakine CX546 bolsters energetic response of astrocytes: a novel target for cognitive-enhancing drugs acting as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators.

Journal: Journal of neurochemistry 20050201

Title: Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus.

Journal: Neuroscience 20040101

Title: Identification of a site in GluR1 and GluR2 that is important for modulation of deactivation and desensitization.

Journal: Molecular pharmacology 20030701

Title: Dynorphin A toxicity in striatal neurons via an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism.

Journal: Neuroscience 20030101

Title: Ampakines reduce methamphetamine-driven rotation and activate neocortex in a regionally selective fashion.

Journal: Neuroscience 20030101

Title: Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

Journal: The Journal of pharmacology and experimental therapeutics 20021201

Title: A remote-controlled high pressure reactor for radiotracer synthesis with [11C]carbon monoxide.

Journal: Nuclear medicine and biology 20021101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Survival signaling and selective neuroprotection through glutamatergic transmission.

Journal: Experimental neurology 20020301

Title: Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

Journal: Neuropharmacology 20011101

Title: Lauterborn JC, et al. Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons. J Neurosci. 2000 Jan 1;20(1):8-21.

Title: Lipina T, et al. The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice. Neuropsychopharmacology. 2007 Apr;32(4):745-56.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:215923-54-9 Molecular Formula|215923-54-9 MDL|215923-54-9 SMILES|215923-54-9 (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(piperidin-1-yl)methanone |Heterocyclic_Building_Blocks