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216167-82-7,MFCD08690469
Catalog No.:AA007POU

216167-82-7 | Butanedioic acid,1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl]ester

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Purity
Availability
Price(USD)
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1mg
98%
in stock  
$14.00   $10.00
- +
5mg
98%
in stock  
$33.00   $23.00
- +
10mg
98%
in stock  
$48.00   $34.00
- +
25mg
98%
in stock  
$82.00   $57.00
- +
50mg
98%
in stock  
$138.00   $96.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007POU
Chemical Name:
Butanedioic acid,1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl]ester
CAS Number:
216167-82-7
Molecular Formula:
C35H52O5S2
Molecular Weight:
616.9144
MDL Number:
MFCD08690469
SMILES:
OC(=O)CCC(=O)Oc1c(cc(cc1C(C)(C)C)SC(Sc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C)(C)C)C(C)(C)C
Properties
Computed Properties
 
Complexity:
870  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
13  
XLogP3:
10.9  

Literature

Title: Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism.

Journal: Journal of pharmaceutical sciences 20120501

Title: Succinobucol induces apoptosis in vascular smooth muscle cells.

Journal: Free radical biology & medicine 20120301

Title: Succinobucol's new coat--conjugation with steroids to alter its drug effect and bioavailability.

Journal: Molecules (Basel, Switzerland) 20111110

Title: Assessment of coronary atherosclerosis by IVUS and IVUS-based imaging modalities: progression and regression studies, tissue composition and beyond.

Journal: The international journal of cardiovascular imaging 20110201

Title: [Novel therapy for atherosclerosis and inflammatory vascular disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110101

Title: Study design and rationale of 'Synergistic effect of combination therapy with cilostazol and ProbUcol on plaque stabilization and lesion REgression (SECURE)' study: a double-blind randomised controlled multicenter clinical trial.

Journal: Trials 20110101

Title: Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.

Journal: Diabetologia 20110101

Title: Probucol and succinobucol in atrial fibrillation: pros and cons.

Journal: International journal of cardiology 20101008

Title: Emerging drugs for hyperlipidemia.

Journal: Expert opinion on emerging drugs 20100901

Title: AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.

Journal: Molecular and cellular endocrinology 20100729

Title: Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.

Journal: Cardiology research and practice 20100101

Title: Analyses of copy number variation of GK rat reveal new putative type 2 diabetes susceptibility loci.

Journal: PloS one 20100101

Title: Heme oxygenase-1 increases endothelial progenitor cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001

Title: Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling.

Journal: American journal of physiology. Cell physiology 20090901

Title: Molecular mechanisms underlying the antiatherosclerotic and antidiabetic effects of probucol, succinobucol, and other probucol analogues.

Journal: Current opinion in lipidology 20090601

Title: Selective thromboxane inhibition after vascular protectant AGI-1067: results of assessment of lipoprotein profiles (ALPS) biomarkers in vitro and in vivo substudy.

Journal: Journal of thrombosis and thrombolysis 20090501

Title: Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects.

Journal: Expert opinion on investigational drugs 20090401

Title: Diabetes treatment.

Journal: Diabetes care 20090301

Title: Current and emerging paradigms in the therapeutic management of atherosclerosis.

Journal: Expert opinion on therapeutic targets 20081201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080901

Title: Novel cardiac therapies and innocent by standers.

Journal: Lancet (London, England) 20080524

Title: Effects of succinobucol (AGI-1067) after an acute coronary syndrome: a randomised, double-blind, placebo-controlled trial.

Journal: Lancet (London, England) 20080524

Title: Effects of the antioxidant succinobucol (AGI-1067) on human atherosclerosis in a randomized clinical trial.

Journal: Atherosclerosis 20080301

Title: Gateways to clinical trials. July-August 2008.

Journal: Methods and findings in experimental and clinical pharmacology 20080101

Title: Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.

Journal: Cardiovascular drugs and therapy 20071201

Title: Pharmacologic approaches to restenosis prevention.

Journal: The American journal of cardiology 20070903

Title: A novel class of antioxidants inhibit LPS induction of tissue factor by selective inhibition of the activation of ASK1 and MAP kinases.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070801

Title: Assessment of lipoprotein profiles study (ALPS) and antioxidant activity in healthy subjects treated with AGI-1067.

Journal: Journal of clinical lipidology 20070801

Title: AGI-1067, a novel vascular protectant, anti-inflammatory drug and mild antiplatelet agent for treatment of atherosclerosis.

Journal: Expert review of cardiovascular therapy 20070701

Title: Follicular development and expression of the messenger ribonucleic acid for the inhibin/activin subunits in two genetic lines of turkey hens that differ in total egg production.

Journal: Poultry science 20070501

Title: Vascular cell adhesion molecule-1: a viable therapeutic target for atherosclerosis?

Journal: International journal of clinical practice 20070401

Title: [Research and developmental strategy of anti-dyslipidemic agents].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401

Title: American Heart Association - Scientific Sessions 2006. Cell therapies for ischemic tissues and treatments for lipid metabolism disorders.

Journal: IDrugs : the investigational drugs journal 20070101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: The in vitro effects of a novel vascular protectant, AGI-1067, on platelet aggregation and major receptor expression in subjects with multiple risk factors for vascular disease.

Journal: Journal of cardiovascular pharmacology and therapeutics 20060901

Title: Are small biotechs still underselling themselves?

Journal: Nature biotechnology 20060501

Title: Antioxidants: the good, the bad and the ugly.

Journal: The Canadian journal of cardiology 20060201

Title: AGI-1067: a novel vascular protectant for prevention of restenosis.

Journal: The Annals of pharmacotherapy 20060101

Title: Antioxidants and atherosclerosis: emerging drug therapies.

Journal: Current atherosclerosis reports 20050201

Title: Inhibition of lipoprotein lipid oxidation.

Journal: Handbook of experimental pharmacology 20050101

Title: Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Journal: Journal of medicinal chemistry 20041202

Title: Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent.

Journal: The Journal of pharmacology and experimental therapeutics 20040301

Title: Pharmacologic prevention of both restenosis and atherosclerosis progression: AGI-1067, probucol, statins, folic acid and other therapies.

Journal: Current opinion in lipidology 20031201

Title: Experimental and clinical studies show that the probucol derivative AGI-1067 prevents vascular growth.

Journal: Expert opinion on investigational drugs 20031101

Title: Vascular protectants for the treatment of atherosclerosis.

Journal: Expert review of cardiovascular therapy 20030901

Title: Signal jammer. An academic experiment leads to a new class of drug for attacking heart disease.

Journal: Scientific American 20030701

Title: AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Chemistry and pharmacology of vascular protectants: a novel approach to the treatment of atherosclerosis and coronary artery disease.

Journal: The American journal of cardiology 20030206

Title: Clinical results with AGI-1067: a novel antioxidant vascular protectant.

Journal: The American journal of cardiology 20030206

Title: Effects of AGI-1067 and probucol after percutaneous coronary interventions.

Journal: Circulation 20030204

Title: Drug reverses coronary atherosclerosis.

Journal: Drug discovery today 20020101

Title: Houston SA, et al. An investigation of the antiplatelet effects of succinobucol (AGI-1067). Platelets. 2017 May;28(3):295-300.

Title: Colle D, et al. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity. Mol Neurobiol. 2016 Mar;53(2):1280-95.

Title: Dan Z, et al. A pH-Responsive Host-guest Nanosystem Loading Succinobucol Suppresses Lung Metastasis of Breast Cancer. Theranostics. 2016 Jan 25;6(3):435-45.

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Tags:216167-82-7 Molecular Formula|216167-82-7 MDL|216167-82-7 SMILES|216167-82-7 Butanedioic acid,1-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenyl]ester