Title: Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress.
Journal: The Journal of pharmacology and experimental therapeutics 20171001
Title: High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.
Journal: Archives of toxicology 20170101
Title: Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression.
Journal: Toxicology letters 20161116
Title: Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.
Journal: Toxicology letters 20160930
Title: Bardoxolone methyl prevents obesity and hypothalamic dysfunction.
Journal: Chemico-biological interactions 20160825
Title: Bardoxolone methyl prevents the development and progression of cardiac and renal pathophysiologies in mice fed a high-fat diet.
Journal: Chemico-biological interactions 20160105
Title: CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.
Journal: PloS one 20160101
Title: Bardoxolone methyl prevents fat deposition and inflammation in the visceral fat of mice fed a high-fat diet.
Journal: Chemico-biological interactions 20150305
Title: Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress.
Journal: Neoplasia (New York, N.Y.) 20140901
Title: Chemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoids.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140801
Title: Immunosuppressive potential of bardoxolone methyl using a modified murine local lymph node assay (LLNA).
Journal: The Journal of toxicological sciences 20140801
Title: Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway.
Journal: Toxicology 20140406
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.
Journal: Journal of the American Society of Nephrology : JASN 20120928
Title: Inhibition of cell proliferation and induction of apoptosis by oleanane triterpenoid (CDDO-Me) in pancreatic cancer cells is associated with the suppression of hTERT gene expression and its telomerase activity.
Journal: Biochemical and biophysical research communications 20120615
Title: Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.
Journal: Journal of medicinal chemistry 20120524
Title: Oleanolic acid.
Journal: Phytochemistry 20120501
Title: The triterpenoid CDDO-Me promotes hematopoietic progenitor expansion and myelopoiesis in mice.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120301
Title: New hope or drawbacks: will chronic kidney disease be treatable with small molecules in the near future?
Journal: Future medicinal chemistry 20120301
Title: Deal watch: Abbott boosts investment in NRF2 activators for reducing oxidative stress.
Journal: Nature reviews. Drug discovery 20120201
Title: Oleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells.
Journal: Biochemical and biophysical research communications 20120106
Title: CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
Journal: Cancer prevention research (Philadelphia, Pa.) 20120101
Title: Electrophilic PPARγ ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.
Journal: Experimental eye research 20120101
Title: [Chronic kidney disease, new therapeutic approaches].
Journal: La Revue du praticien 20120101
Title: Prospective safety study of bardoxolone methyl in patients with type 2 diabetes mellitus, end-stage renal disease and peritoneal dialysis.
Journal: Contributions to nephrology 20120101
Title: Cardiac and renal function in patients with type 2 diabetes who have chronic kidney disease: potential effects of bardoxolone methyl.
Journal: Drug design, development and therapy 20120101
Title: Inhibition of cell proliferation and induction of apoptosis by CDDO-Me in pancreatic cancer cells is ROS-dependent.
Journal: Journal of experimental therapeutics & oncology 20120101
Title: Synthetic oleanane triterpenoid, CDDO-Me, induces apoptosis in ovarian cancer cells by inhibiting prosurvival AKT/NF-κB/mTOR signaling.
Journal: Anticancer research 20111101
Title: Bardoxolone: augmenting the Yin in chronic kidney disease.
Journal: Diabetes & vascular disease research 20111001
Title: Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.
Journal: Toxicology and applied pharmacology 20110901
Title: Diabetes: bardoxolone improves kidney function in type 2 diabetes.
Journal: Nature reviews. Nephrology 20110823
Title: Bardoxolone methyl and kidney function in CKD with type 2 diabetes.
Journal: The New England journal of medicine 20110728
Title: Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury.
Journal: Free radical biology & medicine 20110701
Title: Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.
Journal: American journal of physiology. Renal physiology 20110501
Title: Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.
Journal: Journal of medicinal chemistry 20110324
Title: Effect of bardoxolone methyl on kidney function in patients with T2D and Stage 3b-4 CKD.
Journal: American journal of nephrology 20110101
Title: Role of reactive oxygen species (ROS) in CDDO-Me-mediated growth inhibition and apoptosis in colorectal cancer cells.
Journal: Journal of experimental therapeutics & oncology 20110101
Title: Bardoxolone methyl: a targeted antioxidant.
Journal: Renal failure 20110101
Title: The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice.
Journal: The Journal of biological chemistry 20101224
Title: Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Journal: Cancer prevention research (Philadelphia, Pa.) 20101101
Title: Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.
Journal: The Journal of biological chemistry 20100903
Title: Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma.
Journal: Spine 20100815
Title: Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100701
Title: Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation.
Journal: Molecular cancer research : MCR 20100701
Title: The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20100701
Title: CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells.
Journal: Radiation research 20100701
Title: The triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20100601
Title: Fatty acid synthesis is a therapeutic target in human liposarcoma.
Journal: International journal of oncology 20100501
Title: Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100315
Title: Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-{kappa}B signaling proteins in colorectal cancer cells.
Journal: Anticancer research 20100301
Title: Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells through a ROS-dependent mechanism.
Journal: Biochemical pharmacology 20100201
Title: Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway.
Journal: BMC cancer 20100101
Title: Inhibition of nuclear factor-kappa B differentially affects thyroid cancer cell growth, apoptosis, and invasion.
Journal: Molecular cancer 20100101
Title: Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Journal: Cancer prevention research (Philadelphia, Pa.) 20091201
Title: Oleanane triterpenoid CDDO-Me inhibits growth and induces apoptosis in prostate cancer cells by independently targeting pro-survival Akt and mTOR.
Journal: The Prostate 20090601
Title: CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.
Journal: Cancer chemotherapy and pharmacology 20090301
Title: Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20081014
Title: Coupling of endoplasmic reticulum stress to CDDO-Me-induced up-regulation of death receptor 5 via a CHOP-dependent mechanism involving JNK activation.
Journal: Cancer research 20080915
Title: Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080715
Title: Synthetic triterpenoids have cytotoxicity in pediatric acute lymphoblastic leukemia cell lines but cytotoxicity is independent of induced ceramide increase in MOLT-4 cells.
Journal: Leukemia 20080601
Title: Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.
Journal: Molecular cancer therapeutics 20080501
Title: Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.
Journal: Cancer research 20080415
Title: The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection.
Journal: Journal of neuroinflammation 20080101
Title: Immunomodulatory activity of synthetic triterpenoids: inhibition of lymphocyte proliferation, cell-mediated cytotoxicity, and cytokine gene expression through suppression of NF-kappaB.
Journal: Immunopharmacology and immunotoxicology 20080101
Title: The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent.
Journal: Molecular cancer therapeutics 20071201
Title: PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Journal: Cancer biology & therapy 20071201
Title: Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils.
Journal: Antioxidants & redox signaling 20071101
Title: c-FLIP downregulation contributes to apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me) in human lung cancer cells.
Journal: Cancer biology & therapy 20071001
Title: Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling.
Journal: Journal of neuro-oncology 20070901
Title: The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling.
Journal: Cancer research 20070501
Title: The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.
Journal: Cancer research 20070315
Title: CDDO-me induces apoptosis and inhibits Akt, mTOR and NF-kappaB signaling proteins in prostate cancer cells.
Journal: Anticancer research 20070101
Title: Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
Journal: The Journal of biological chemistry 20061124
Title: Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
Journal: Cancer biology & therapy 20060501
Title: A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060315
Title: The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells.
Journal: Leukemia 20050801
Title: c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.
Journal: Cancer research 20041015
Title: Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets.
Journal: Journal of medicinal chemistry 20040923
Title: Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL.
Journal: Leukemia 20031101
Title: A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide production.
Journal: Bioorganic & medicinal chemistry letters 20020408
Title: Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia.
Journal: Blood 20020101
Title: Identification of a novel synthetic triterpenoid, methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate, that potently induces caspase-mediated apoptosis in human lung cancer cells.
Journal: Molecular cancer therapeutics 20020101
Title: A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor gamma.
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