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2196-62-5,MFCD09750768
Catalog No.:AA007ONN

2196-62-5 | TDP-Glucose

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007ONN
Chemical Name:
TDP-Glucose
CAS Number:
2196-62-5
Molecular Formula:
C16H26N2O16P2
Molecular Weight:
564.3290
MDL Number:
MFCD09750768
SMILES:
OCC1OC(OP(=O)(OP(=O)(OCC2OC(CC2O)n2cc(C)c(=O)[nH]c2=O)O)O)C(C(C1O)O)O
Properties
Computed Properties
 
Complexity:
978  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
9  
XLogP3:
-5.5  

Literature

Title: Lipophilic sugar nucleotide synthesis by structure-based design of nucleotidylyltransferase substrates.

Journal: Organic & biomolecular chemistry 20080207

Title: Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor.

Journal: Journal of medicinal chemistry 20070503

Title: Synthesis and evaluation of mimetics of UDP and UDP-alpha-D-galactose, dTDP and dTDP-alpha-D-glucose with monosaccharides replacing the key pyrophosphate unit.

Journal: Organic & biomolecular chemistry 20050321

Title: Metabolic block at early stages of the glycolytic pathway activates the Rcs phosphorelay system via increased synthesis of dTDP-glucose in Escherichia coli.

Journal: Molecular microbiology 20040201

Title: High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae.

Journal: The Journal of biological chemistry 20040116

Title: Isolation and characterization of bluensomycin biosynthetic genes from Streptomyces bluensis.

Journal: FEMS microbiology letters 20030227

Title: Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase.

Journal: Journal of molecular biology 20011102

Title: Mechanistic roles of Thr134, Tyr160, and Lys 164 in the reaction catalyzed by dTDP-glucose 4,6-dehydratase.

Journal: Biochemistry 20010807

Title: Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site.

Journal: Biochemistry 20010605

Title: [Cloning of the sugar related biosynthesis gene cluster from Streptomyces tenebrarius H6].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20010501

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