Home Pyridines 221148-46-5
221148-46-5,MFCD09475687
Catalog No.:AA00BJVD

221148-46-5 | 2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE

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Purity
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1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
≥98%
in stock  
$348.00   $243.00
- +
25mg
≥98%
in stock  
$736.00   $515.00
- +
  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BJVD
Chemical Name:
2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE
CAS Number:
221148-46-5
Molecular Formula:
C21H19N3O3S
Molecular Weight:
393.4589
MDL Number:
MFCD09475687
SMILES:
CCOc1ccc(cc1)c1nn2c(c1c1ccc(cc1)S(=O)(=O)C)cccn2
Properties
Computed Properties
 
Complexity:
607  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
3.5  

Literature

Title: 'Greener' Friedel-Crafts acylations: a metal- and halogen-free methodology.

Journal: Organic letters 20110506

Title: A randomized, controlled, dose-ranging study investigating single doses of GW406381, naproxen sodium, or placebo in patients with acute pain after third molar tooth extraction.

Journal: The Clinical journal of pain 20090901

Title: A double-blind, randomized, placebo-controlled, single-dose study of the cyclooxygenase-2 inhibitor, GW406381, as a treatment for acute migraine.

Journal: European journal of neurology 20080401

Title: Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies.

Journal: Medscape journal of medicine 20080101

Title: GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury.

Journal: Pain 20070301

Title: The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.

Journal: The Journal of pharmacology and experimental therapeutics 20050301

Title: Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20041101

Title: Factors affecting incorporation of drug into solid solution with HPMCP during solvent change co-precipitation.

Journal: International journal of pharmaceutics 20021001

Title: Zhao FY, et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain. 2007 Mar;128(1-2):78-87.

Title: Boswell DJ, et al. Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Medscape J Med. 2008;10(11):259.

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Tags:221148-46-5 Molecular Formula|221148-46-5 MDL|221148-46-5 SMILES|221148-46-5 2-(4-ETHOXYFENYL)-3-(4-MESYLFENYL)PYRAZOLO[1,5-B]PYRIDAZINE