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221244-14-0,MFCD17010191
Catalog No.:AA007PGJ

221244-14-0 | PP1 Analog II, 1NM-PP1

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Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$14.00   $10.00
- +
5mg
98%
in stock  
$39.00   $28.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007PGJ
Chemical Name:
PP1 Analog II, 1NM-PP1
CAS Number:
221244-14-0
Molecular Formula:
C20H21N5
Molecular Weight:
331.4142
MDL Number:
MFCD17010191
SMILES:
Nc1ncnc2c1c(Cc1cccc3c1cccc3)nn2C(C)(C)C
Properties
Computed Properties
 
Complexity:
462  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.

Journal: Journal of medicinal chemistry 20120308

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.

Journal: Journal of cell science 20080315

Title: The selectivity of protein kinase inhibitors: a further update.

Journal: The Biochemical journal 20071215

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Assignment of protein function in the postgenomic era.

Journal: Nature chemical biology 20050801

Title: Bishop A C, et al. Generation of Monospecific Nanomolar Tyrosine Kinase Inhibitors via a Chemical Genetic Approach. Journal of the American Chemical Society, 1999, 121(4):627-631.

Title: Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401.

Title: Larochelle S, et al. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell. 2007 Mar 23;25(6):839-50.

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SDS
Tags:221244-14-0 Molecular Formula|221244-14-0 MDL|221244-14-0 SMILES|221244-14-0 PP1 Analog II, 1NM-PP1