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222551-17-9,MFCD11973649
Catalog No.:AA00BEZ7

222551-17-9 | adoprazine

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5mg
≥98%
in stock  
$481.00   $337.00
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10mg
≥98%
in stock  
$777.00   $544.00
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50mg
≥98%
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$1,966.00   $1,377.00
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  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BEZ7
Chemical Name:
adoprazine
CAS Number:
222551-17-9
Molecular Formula:
C24H24FN3O2
Molecular Weight:
405.4647
MDL Number:
MFCD11973649
SMILES:
Fc1ccc(cc1)c1cncc(c1)CN1CCN(CC1)c1cccc2c1OCCO2
Properties
Computed Properties
 
Complexity:
537  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
4  
XLogP3:
3.7  

Literature

Title: Comparative pharmacology of antipsychotics possessing combined dopamine D2 and serotonin 5-HT1A receptor properties.

Journal: Psychopharmacology 20110801

Title: Differences among conventional, atypical and novel putative D(2)/5-HT(1A) antipsychotics on catalepsy-associated behaviour in cynomolgus monkeys.

Journal: Behavioural brain research 20091105

Title: Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.

Journal: Journal of medicinal chemistry 20071018

Title: Towards a new generation of potential antipsychotic agents combining D2 and 5-HT1A receptor activities.

Journal: Journal of medicinal chemistry 20070222

Title: SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070101

Title: Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060901

Title: SAR study of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees of (Ant)agonism. Selection of a potential atypical antipsychotic.

Journal: Chemical & pharmaceutical bulletin 20060901

Title: Partial agonist properties of the antipsychotics SSR181507, aripiprazole and bifeprunox at dopamine D2 receptors: G protein activation and prolactin release.

Journal: European journal of pharmacology 20060327

Title: Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase.

Journal: European journal of pharmacology 20060318

Title: Novel antipsychotic agents with 5-HT(1A) agonist properties: role of 5-HT(1A) receptor activation in attenuation of catalepsy induction in rats.

Journal: Neuropharmacology 20050801

Title: Andrew C McCreary, et al. SLV313 (1-(2,3-dihydro-benzo,4dioxin-5-yl)-4- -(4-fluoro-phenyl)-pyridin-3-ylmethyl-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology. 2007 Jan;32(1):78-94.

Title: Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534(1-3):63-70.

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