[1]CurrentPatentAssignee:TAISHOPHARMACEUTICALHOLDINGSCOLTD-US6162832,2000,A
[1]DeLaCruz,GemmaGuedes;Groschner,Klaus;OliverKappe;Glasnov,TomaN.[TetrahedronLetters,2012,vol.53,#29,p.3731-3734]
[1]DeLaCruz,GemmaGuedes;Groschner,Klaus;OliverKappe;Glasnov,TomaN.[TetrahedronLetters,2012,vol.53,#29,p.3731-3734]
[1]DeLaCruz,GemmaGuedes;Groschner,Klaus;OliverKappe;Glasnov,TomaN.[TetrahedronLetters,2012,vol.53,#29,p.3731-3734]
[1]TetrahedronLetters,2012,vol.53,p.3731-3734
Title: Axonal protection achieved by blockade of sodium/calcium exchange in a new model of ischemia in vivo.
Journal: Neuropharmacology 20120901
Title: Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?
Journal: American journal of physiology. Heart and circulatory physiology 20120415
Title: Molecular and functional characterization of the human platelet Na(+) /Ca(2+) exchangers.
Journal: British journal of pharmacology 20120201
Title: SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease.
Journal: Neuropharmacology 20111201
Title: The specific Na(+)/Ca(2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells.
Journal: Neurochemistry international 20110801
Title: Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.
Journal: Brain research 20101202
Title: KB-R7943 inhibits Na+-dependent Mg2+ efflux in rat ventricular myocytes.
Journal: The journal of physiological sciences : JPS 20101101
Title: Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20101101
Title: Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure.
Journal: American journal of physiology. Heart and circulatory physiology 20100501
Title: I(Ks) restricts excessive beat-to-beat variability of repolarization during beta-adrenergic receptor stimulation.
Journal: Journal of molecular and cellular cardiology 20100101
Title: Cerebral ischemia elicits aberration in myocardium contractile function and intracellular calcium handling.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101
Title: Assessing manganese efflux using SEA0400 and cardiac T1-mapping manganese-enhanced MRI in a murine model.
Journal: NMR in biomedicine 20091001
Title: Involvement of protein kinase C in the regulation of Na+/Ca2+ exchanger in bovine adrenal chromaffin cells.
Journal: Clinical and experimental pharmacology & physiology 20090701
Title: Role of Na+/Ca2+ exchanger-mediated Ca2+ entry in pressure-induced myogenic constriction in rat posterior cerebral arteries.
Journal: Journal of pharmacological sciences 20090601
Title: Involvement of the Na(+)/Ca(2+) exchanger in the automaticity of guinea-pig pulmonary vein myocardium as revealed by SEA0400.
Journal: Journal of pharmacological sciences 20090501
Title: A Na+/Ca2+ exchanger isoform, NCX1, is involved in retinal cell death after N-methyl-D-aspartate injection and ischemia-reperfusion.
Journal: Journal of neuroscience research 20090301
Title: Potential therapeutic effects of Na+/Ca2+ exchanger inhibition in cardiac diseases.
Journal: Current medicinal chemistry 20090101
Title: Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3.
Journal: Heart rhythm 20081001
Title: Antiarrhythmic benefits of targeting the Na+/Ca2+ exchanger.
Journal: Heart rhythm 20081001
Title: Burst emergence of intracellular Ca2+ waves evokes arrhythmogenic oscillatory depolarization via the Na+-Ca2+ exchanger: simultaneous confocal recording of membrane potential and intracellular Ca2+ in the heart.
Journal: Circulation research 20080829
Title: SEA0400 fails to alter the magnitude of intracellular Ca2+ transients and contractions in Langendorff-perfused guinea pig heart.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080701
Title: Pharmacological inhibition of na/ca exchange results in increased cellular Ca2+ load attributable to the predominance of forward mode block.
Journal: Circulation research 20080606
Title: The ins and outs of calcium in heart failure.
Journal: Circulation research 20080606
Title: The Na+/Ca2+ exchange blocker SEA0400 fails to enhance cytosolic Ca2+ transient and contractility in canine ventricular cardiomyocytes.
Journal: Cardiovascular research 20080601
Title: Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart.
Journal: British journal of pharmacology 20080501
Title: Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080201
Title: Effect of partial blockade of the Na(+)/Ca(2+)-exchanger on Ca(2+) handling in isolated rat ventricular myocytes.
Journal: European journal of pharmacology 20071208
Title: S1P1-selective agonist SEW2871 exacerbates reperfusion arrhythmias.
Journal: Journal of cardiovascular pharmacology 20071201
Title: Mechanisms of endothelin-1-induced decrease in contractility in adult mouse ventricular myocytes.
Journal: British journal of pharmacology 20071001
Title: Negative inotropic effects of endothelin-1 in mouse cardiomyocytes: evidence of a role for Na+-Ca2+ exchange.
Journal: British journal of pharmacology 20071001
Title: [Molecular pharmacologic approaches to functional analysis of new biological target molecules for drug discovery].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071001
Title: Preservation of mitochondrial function may contribute to cardioprotective effects of Na+/Ca2+ exchanger inhibitors in ischaemic/reperfused rat hearts.
Journal: British journal of pharmacology 20070801
Title: Monensin causes transient calcium ion influx into mouse splenic lymphocytes in a sodium ion-independent fashion.
Journal: European journal of pharmacology 20070430
Title: Interaction between Na+/K+-pump and Na+/Ca2+-exchanger modulates intercellular communication.
Journal: Circulation research 20070413
Title: [Na+/Ca2+ exchanger (NCX1) and cardiovascular disease].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20070401
Title: Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice.
Journal: British journal of pharmacology 20070201
Title: Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis in guinea-pig myocardium as revealed by SEA0400.
Journal: Journal of pharmacological sciences 20070201
Title: SEA0400, a novel Na+/Ca2+ exchanger inhibitor, reduces calcium overload induced by ischemia and reperfusion in mouse ventricular myocytes.
Journal: Physiological research 20070101
Title: Anesthetic preconditioning enhances Ca2+ handling and mechanical and metabolic function elicited by Na+-Ca2+ exchange inhibition in isolated hearts.
Journal: Anesthesiology 20060901
Title: Inhibition by SEA0400, a selective inhibitor of Na+/Ca2+ exchanger, of Na+ -dependent Ca2+ uptake and catecholamine release in bovine adrenal chromaffin cells.
Journal: Journal of pharmacological sciences 20060901
Title: Reduction by SEA0400 of myocardial ischemia-induced cytoplasmic and mitochondrial Ca2+ overload.
Journal: European journal of pharmacology 20060814
Title: Quantitative fluorescence measurement of cardiac Na+/Ca2+ exchanger inhibition by kinetic analysis in stably transfected HEK293 cells.
Journal: Journal of pharmacological sciences 20060801
Title: Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger.
Journal: Circulation 20060704
Title: Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.
Journal: Kidney international 20060601
Title: Sodium-dependent recovery of ionised magnesium concentration following magnesium load in rat heart myocytes.
Journal: Pflugers Archiv : European journal of physiology 20060201
Title: A selective inhibitor of Na+/Ca2+ exchanger, SEA0400, preserves cardiac function and high-energy phosphates against ischemia/reperfusion injury.
Journal: Journal of cardiovascular pharmacology 20060201
Title: [Na+/Ca2+ exchanger(NCX1) and salt-sensitive hypertension].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060101
Title: Sodium calcium exchange as a target for antiarrhythmic therapy.
Journal: Handbook of experimental pharmacology 20060101
Title: Salt-sensitive hypertension, Na+/Ca2+ exchanger, and vascular smooth muscle.
Journal: Trends in cardiovascular medicine 20051101
Title: Effects of SEA0400 and KB-R7943 on Na+/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050701
Title: Cardioprotection without cardiosuppression by SEA0400, a novel inhibitor of Na+-Ca2+ exchanger, during ischemia and reperfusion in guinea-pig myocardium.
Journal: Life sciences 20050603
Title: SEA-0400, a potent inhibitor of the Na+/Ca2+ exchanger, as a tool to study exchanger ionic and metabolic regulation.
Journal: American journal of physiology. Cell physiology 20050601
Title: Unique excitation-contraction characteristics of mouse myocardium as revealed by SEA0400, a specific inhibitor of Na+-Ca2+ exchanger.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050601
Title: Therapeutic potential of novel Na+-Ca2+ exchange inhibitors in attenuating ischemia-reperfusion injury.
Journal: The Canadian journal of cardiology 20050501
Title: SEA0400, a specific inhibitor of the Na+-Ca2+ exchanger, attenuates sodium nitroprusside-induced apoptosis in cultured rat microglia.
Journal: British journal of pharmacology 20050301
Title: Functional proteins involved in regulation of intracellular Ca(2+) for drug development: pharmacology of SEA0400, a specific inhibitor of the Na(+)-Ca(2+) exchanger.
Journal: Journal of pharmacological sciences 20050301
Title: Effects of SEA0400, a Na+/Ca2+ exchange inhibitor, on ventricular arrhythmias in the in vivo dogs.
Journal: European journal of pharmacology 20050104
Title: Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early and delayed after depolarization in canine heart.
Journal: British journal of pharmacology 20041201
Title: Effects of SEA0400, a novel inhibitor of the Na+/Ca2+ exchanger, on myocardial stunning in anesthetized dogs.
Journal: European journal of pharmacology 20041128
Title: Inhibitory profile of SEA0400 [2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline] assessed on the cardiac Na+-Ca2+ exchanger, NCX1.1.
Journal: The Journal of pharmacology and experimental therapeutics 20041101
Title: Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle.
Journal: Nature medicine 20041101
Title: Hypertension with a grain of salt.
Journal: Nature medicine 20041101
Title: Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of Na+/Ca2+ exchange inhibitors.
Journal: Journal of pharmacological sciences 20040901
Title: Functional role of the Na+/H+ exchanger in the regulation of cerebral arteriolar tone in rats.
Journal: Journal of neurosurgery 20040801
Title: Effects of sodium-calcium exchange inhibitors, KB-R7943 and SEA0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies.
Journal: The Journal of pharmacology and experimental therapeutics 20040701
Title: Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury.
Journal: Molecular pharmacology 20040701
Title: The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease.
Journal: Expert opinion on investigational drugs 20040601
Title: Cardioprotective effect of SEA0400, a selective inhibitor of the Na(+)/Ca(2+) exchanger, on myocardial ischemia-reperfusion injury in rats.
Journal: Journal of pharmacological sciences 20040601
Title: The selective Na+-Ca2+ exchange inhibitor attenuates brain edema after radiofrequency lesion in rats.
Journal: European journal of pharmacology 20040412
Title: Development and application of Na+/Ca2+ exchange inhibitors.
Journal: Molecular and cellular biochemistry 20040401
Title: Effects of SEA0400 on mutant NCX1.1 Na+-Ca2+ exchangers with altered ionic regulation.
Journal: Molecular pharmacology 20040301
Title: Molecular determinants of Na+/Ca2+ exchange (NCX1) inhibition by SEA0400.
Journal: The Journal of biological chemistry 20040227
Title: SEA0400: a novel sodium-calcium exchange inhibitor with cardioprotective properties.
Journal: Cardiovascular drug reviews 20040101
Title: Discovery of a novel potent Na+/Ca2+ exchanger inhibitor: design, synthesis and structure-activity relationships of 3,4-dihydro-2(1H)-quinazolinone derivatives.
Journal: Bioorganic & medicinal chemistry letters 20031020
Title: A novel and selective Na+/Ca2+ exchange inhibitor, SEA0400, improves ischemia/reperfusion-induced renal injury.
Journal: European journal of pharmacology 20031008
Title: Differing cardioprotective efficacy of the Na+/Ca2+ exchanger inhibitors SEA0400 and KB-R7943.
Journal: American journal of physiology. Heart and circulatory physiology 20030301
Title: Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.
Journal: European journal of pharmacology 20030101
Title: [Functional analysis of Na+/Ca2+ exchanger using novel drugs and genetically engineered mice].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20021101
Title: Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors.
Journal: Circulation research 20020726
Title: Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents.
Journal: British journal of pharmacology 20020301
Title: SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.
Journal: The Journal of pharmacology and experimental therapeutics 20010701
Title: Order and disorder at hospital meetings.
Journal: Dimensions in health service 19751201
