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223387-75-5,MFCD23136998
Catalog No.:AA0038ZV

223387-75-5 | Fg-2216

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
in stock  
$32.00   $22.00
- +
2mg
99%
in stock  
$53.00   $37.00
- +
5mg
99%
in stock  
$78.00   $55.00
- +
50mg
99%
in stock  
$299.00   $210.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0038ZV
Chemical Name:
Fg-2216
CAS Number:
223387-75-5
Molecular Formula:
C12H9ClN2O4
Molecular Weight:
280.6639
MDL Number:
MFCD23136998
SMILES:
OC(=O)CNC(=O)c1nc(Cl)c2c(c1O)cccc2
Properties
Computed Properties
 
Complexity:
366  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
2.5  

Literature

Title: Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.

Journal: ACS chemical biology 20130719

Title: Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors.

Journal: Molecular biology reports 20120401

Title: The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120301

Title: Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.

Journal: Journal of medicinal chemistry 20100128

Title: Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Journal: Journal of medicinal chemistry 20090514

Title: Gas phase reaction of substituted isoquinolines to carboxylic acids in ion trap and triple quadrupole mass spectrometers after electrospray ionization and collision-induced dissociation.

Journal: Journal of the American Society for Mass Spectrometry 20080101

Title: Hong YR, et al. [(4-Hydroxyl-benzo,5thieno,2-cpyridine-3-carbonyl)-amino-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues. Bioorg Med Chem Lett. 2013 Nov 1;23(21):5953-7.

Title: Hsieh MM, et al. HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques. Blood. 2007 Sep 15;110(6):2140-7.

Title: Bernhardt WM, et, al. Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD. J Am Soc Nephrol. 2010 Dec;21(12):2151-6.

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