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2235-97-4,MFCD00069207
Catalog No.:AA01E3QU

2235-97-4 | 5-(N,N-dimethyl)-Amiloride(hydrochloride)

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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$166.00   $116.00
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25mg
≥97%
in stock  
$304.00   $213.00
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100mg
≥97%
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$890.00   $623.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E3QU
Chemical Name:
5-(N,N-dimethyl)-Amiloride(hydrochloride)
CAS Number:
2235-97-4
Molecular Formula:
C8H13Cl2N7O
Molecular Weight:
294.1411
MDL Number:
MFCD00069207
SMILES:
NC(=NC(=O)c1nc(Cl)c(nc1N)N(C)C)N.Cl
Properties
Computed Properties
 
Complexity:
317  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
0.1  

Literature

Title: Role of the spinal Na+/H+ exchanger in formalin-induced nociception.

Journal: Neuroscience letters 20110821

Title: Discovery of selective bioactive small molecules by targeting an RNA dynamic ensemble.

Journal: Nature chemical biology 20110626

Title: Non-genomic rapid inhibition of Na+/H+-exchange 1 and apoptotic immunosuppression in human T cells by glucocorticoids.

Journal: Journal of cellular physiology 20100601

Title: Hsp60 is actively secreted by human tumor cells.

Journal: PloS one 20100101

Title: Stimulation by sparkling water of gastroduodenal HCO3- secretion in rats.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20091201

Title: Elevated hydrostatic pressure activates sodium/hydrogen exchanger-1 in rat optic nerve head astrocytes.

Journal: American journal of physiology. Cell physiology 20090701

Title: Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.

Journal: Pharmaceutical research 20090501

Title: Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).

Journal: Bioorganic & medicinal chemistry letters 20090501

Title: Dimethyl amiloride, a Na+-H+ exchange inhibitor, and its cardioprotective effects in hemorrhagic shock in in vivo resuscitated rats.

Journal: The journal of physiological sciences : JPS 20090501

Title: Identification of the Na+/H+ exchanger 1 in dorsal root ganglion and spinal cord: its possible role in inflammatory nociception.

Journal: Neuroscience 20090421

Title: Inhibitions of chloride transport and gap junction reduce fluid flow across the whole porcine ciliary epithelium.

Journal: Investigative ophthalmology & visual science 20090301

Title: Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090201

Title: Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils.

Journal: American journal of physiology. Cell physiology 20081101

Title: Ouabain-induced stimulation of sodium-hydrogen exchange in rat optic nerve astrocytes.

Journal: American journal of physiology. Cell physiology 20080701

Title: Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes.

Journal: American journal of physiology. Endocrinology and metabolism 20080601

Title: Protection of ischaemic-reperfused rat heart by dimethylamiloride is associated with inhibition of mitochondrial permeability transition.

Journal: Clinical and experimental pharmacology & physiology 20080201

Title: Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080201

Title: Solute diffusion through stripped mouse duodenum.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201

Title: Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly.

Journal: American journal of physiology. Cell physiology 20071101

Title: HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Studies on the mechanisms underlying amiloride enhancement of 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats.

Journal: European journal of pharmacology 20070521

Title: The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells.

Journal: Journal of cellular physiology 20070501

Title: Inhibition of lipopolysaccharide-induced prostaglandin E2 production and inflammation by the Na+/H+ exchanger inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: Mechanisms of secretion-associated shrinkage and volume recovery in cultured rabbit parietal cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20070301

Title: Measurement of the filtration coefficient (Kfc) in the lung of Gallus domesticus and the effects of increased microvascular permeability.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060801

Title: Carbonic anhydrases and mucosal vanilloid receptors help mediate the hyperemic response to luminal CO2 in rat duodenum.

Journal: Gastroenterology 20060701

Title: Epithelial carbonic anhydrases facilitate PCO2 and pH regulation in rat duodenal mucosa.

Journal: The Journal of physiology 20060615

Title: [Effect of the NHE-1-specific inhibitor DMA on pHi, proliferation and apoptosis of HL-60/ADM cells in vitro].

Journal: Zhongguo shi yan xue ye xue za zhi 20060601

Title: Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts.

Journal: Archives of physiology and biochemistry 20060201

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages.

Journal: Antimicrobial agents and chemotherapy 20040601

Title: NHE3 inhibition activates duodenal bicarbonate secretion in the rat.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040101

Title: Endothelin receptor blockade has an oxygen-saving effect in Dahl salt-sensitive rats with heart failure.

Journal: American journal of physiology. Heart and circulatory physiology 20031001

Title: [3H]-DA release evoked by low pH medium and internal H+ accumulation in rat hypothalamic synaptosomes: involvement of calcium ions.

Journal: Neurochemistry international 20030701

Title: CO2 transduction in avian intrapulmonary chemoreceptors is critically dependent on transmembrane Na+/H+ exchange.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030601

Title: Secretion of acid and base equivalents by intact distal airways.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030501

Title: Inhibition of apical Na+/H+ exchangers on the macula densa cells augments tubuloglomerular feedback.

Journal: Hypertension (Dallas, Tex. : 1979) 20030301

Title: Noninvasive assessment of aqueous humor turnover in the mouse eye.

Journal: Investigative ophthalmology & visual science 20030201

Title: The role of Na+/H+ exchange in the efficacy of multidose hypothermic cardioplegia in immature rabbit hearts.

Journal: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20021201

Title: The route of bacterial uptake by macrophages influences the repertoire of epitopes presented to CD4 T cells.

Journal: European journal of immunology 20021201

Title: Influence of ANG II on cytoplasmic sodium in cultured rabbit nonpigmented ciliary epithelium.

Journal: American journal of physiology. Cell physiology 20020801

Title: Liquid secretion inhibitors reduce mucociliary transport in glandular airways.

Journal: American journal of physiology. Lung cellular and molecular physiology 20020801

Title: Enhancement of Ca(2+) transients and contraction of single ventricular myocytes of rats by 5-(N,N-dimethyl) amiloride.

Journal: Sheng li xue bao : [Acta physiologica Sinica] 20020625

Title: Metabolic activation of A549 human airway epithelial cells by organic dust: a study based on microphysiometry.

Journal: Life sciences 20020607

Title: Inhibitors of NHE-1 Na+/H+ exchange reduce mouse intraocular pressure.

Journal: Investigative ophthalmology & visual science 20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Uptake and processing of Chlamydia trachomatis by human dendritic cells.

Journal: European journal of immunology 20020301

Title: Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.

Journal: European biophysics journal : EBJ 20020301

Title: Ischemic preconditioning and Na+/H+ exchange inhibition improve reperfusion ion homeostasis.

Journal: The Annals of thoracic surgery 20020201

Title: Roles of NHE-1 in the proliferation and apoptosis of pulmonary artery smooth muscle cells in rats.

Journal: Chinese medical journal 20020101

Title: pH paradox and neonatal heart.

Journal: The Journal of cardiovascular surgery 20010801

Title: Inhibition of mechanical activation of guinea-pig airway afferent neurons by amiloride analogues.

Journal: British journal of pharmacology 20010801

Title: Inhibition of the Na(+)/H(+) antiporter suppresses IL-12 p40 production by mouse macrophages.

Journal: Biochimica et biophysica acta 20010620

Title: Acute adaptive cellular base uptake in rat duodenal epithelium.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010601

Title: NHE and ICAM-1 expression in hypoxic/reoxygenated coronary microvascular endothelial cells.

Journal: American journal of physiology. Heart and circulatory physiology 20010601

Title: Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart.

Journal: Circulation 20010320

Title: Gramicidin-perforated patch analysis on HCO3- secretion through a forskolin-activated anion channel in rat parotid intralobular duct cells.

Journal: The Journal of membrane biology 20010301

Title: Ion exchange activity in pulmonary artery smooth muscle cells: the response to hypoxia.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010201

Title: The effect of 5'-(N,N-dimethyl)-amiloride on cytotoxic activity of doxorubicin and vincristine in CEM cell lines.

Journal: Physiological research 20010101

Title: Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3.

Journal: American journal of physiology. Cell physiology 20001201

Title: Heparin-like molecules inhibit pulmonary vascular pericyte proliferation in vitro.

Journal: American journal of physiology. Lung cellular and molecular physiology 20000801

Title: Sodium transport inhibitors decrease proliferation of Pneumocystis carinii in short-term culture.

Journal: The Journal of eukaryotic microbiology 19940101

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