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2250025-93-3
Catalog No.:AA01LQ63

2250025-93-3 | Clozapine n-oxide dihydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$79.00   $55.00
- +
10mg
≥98%
in stock  
$142.00   $99.00
- +
25mg
≥98%
in stock  
$256.00   $179.00
- +
50mg
≥98%
in stock  
$472.00   $330.00
- +
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  • Technical Information
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Technical Information
Catalog Number:
AA01LQ63
Chemical Name:
Clozapine n-oxide dihydrochloride
CAS Number:
2250025-93-3
Molecular Formula:
C18H21Cl3N4O
Molecular Weight:
415.7445
SMILES:
Clc1ccc2c(c1)N=C(N1CC[N+](CC1)([O-])C)c1c(N2)cccc1.Cl.Cl
Properties

Literature

Title: Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92.

Title: Manvich DF, et al. The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice. Sci Rep. 2018 Mar 1;8(1):3840.

Title: van der Peet PL, et al. Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs. MethodsX. 2018 Mar 23;5:257-267.

Title: Joseph Cichon, et al. Branch-specific dendritic Ca(2+) spikes cause persistent synaptic plasticity. Nature. 2015 Apr 9;520(7546):180-5.

Title: Silva RR, et al. Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor. Front Pharmacol. 2019 Jun 4;10:628.

Title: Zorn SH, et al. Clozapine is a potent and selective muscarinic M4 receptor agonist. Eur J Pharmacol. 1994 Nov 15;269(3):R1-2.

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