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22503-72-6,MFCD00270874
Catalog No.:AA006XNB

22503-72-6 | 7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide

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1g
98%
in stock  
$45.00   $32.00
- +
5g
98%
in stock  
$107.00   $75.00
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25g
98%
in stock  
$444.00   $311.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006XNB
Chemical Name:
7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
CAS Number:
22503-72-6
Molecular Formula:
C8H9ClN2O2S
Molecular Weight:
232.6873
MDL Number:
MFCD00270874
SMILES:
CC1Nc2ccc(cc2S(=O)(=O)N1)Cl
Properties
Computed Properties
 
Complexity:
314  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.5  

Literature

Title: Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

Journal: The Biochemical journal 20120101

Title: The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques.

Journal: Neuropharmacology 20110601

Title: Glutamatergic targets for enhancing extinction learning in drug addiction.

Journal: Current neuropharmacology 20101201

Title: Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.

Journal: Journal of medicinal chemistry 20100311

Title: Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.

Journal: Biochemistry 20090915

Title: A novel class of allosteric modulators of AMPA/Kainate receptors.

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.

Journal: Bioorganic & medicinal chemistry 20081201

Title: Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.

Journal: Journal of medicinal chemistry 20070628

Title: S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures.

Journal: European journal of pharmacology 20070430

Title: Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data.

Journal: Psychopharmacology 20050401

Title: Interactions of allosteric modulators of AMPA/kainate receptors on spreading depression in the chicken retina.

Journal: Brain research 20041029

Title: IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells.

Journal: Neuropharmacology 20040601

Title: The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys.

Journal: Neuropharmacology 20040101

Title: Effects of 5'-alkyl-benzothiadiazides on (R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor biophysics and synaptic responses.

Journal: Molecular pharmacology 20020901

Title: Synthesis of 3,4-dihydro-2H-1,2,4-benzo-thiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/kainate receptors.

Journal: Journal of medicinal chemistry 20020606

Title: 5'-alkyl-benzothiadiazides: a new subgroup of AMPA receptor modulators with improved affinity.

Journal: Bioorganic & medicinal chemistry 20020501

Title: Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

Journal: Neuropharmacology 20011101

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Tags:22503-72-6 Molecular Formula|22503-72-6 MDL|22503-72-6 SMILES|22503-72-6 7-Chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide