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2252403-56-6,MFCD32062763
Catalog No.:AA01JJX4

2252403-56-6 | Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
95%
in stock  
$598.00   $419.00
- +
25mg
95%
in stock  
$1,201.00   $841.00
- +
100mg
95%
in stock  
$2,352.00   $1,647.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01JJX4
Chemical Name:
Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
CAS Number:
2252403-56-6
Molecular Formula:
C30H30F2N6O3
Molecular Weight:
560.5944
MDL Number:
MFCD32062763
SMILES:
C=CC(=O)N1CCN(C(C1)C)c1nc(=O)n(c2c1cc(F)c(n2)c1c(O)cccc1F)c1c(C)ccnc1C(C)C
Properties

Downstream Synthesis Route
126325-50-6   
(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-4-methyl-2-(1-methylethyl)-3-pyridinyl-4-(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinylpyrido2,3-dpyrimidin-2(1H)-one 

[1]Patent:US2018/334454,2018,A1

[2]JournalofMedicinalChemistry,2020,vol.63,p.52-65

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[4]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[5]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[6]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[7]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[4]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[5]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[6]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[7]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[8]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[9]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[10]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[11]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[12]CurrentPatentAssignee:AMGENINC-WO2021/97212,2021,A1

[13]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN115466259,2022,A

[14]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2022/246459,2022,A1

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[4]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[5]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[6]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[7]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[8]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[9]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[10]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[11]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[12]CurrentPatentAssignee:AMGENINC-WO2021/97212,2021,A1

[13]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN115466259,2022,A

[14]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2022/246459,2022,A1

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[4]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[5]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[6]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[7]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[8]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[9]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[10]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[11]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[12]CurrentPatentAssignee:AMGENINC-WO2021/97212,2021,A1

[13]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN115466259,2022,A

[14]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2022/246459,2022,A1

Literature

Title: Karen Rex, et al. Abstract 3090: In vivo characterization of AMG 510 - a potent and selective KRASG12Ccovalent small molecule inhibitor in preclinical KRASG12Ccancer models. Experimental and Molecular Therapeutics.

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Tags:2252403-56-6 Molecular Formula|2252403-56-6 MDL|2252403-56-6 SMILES|2252403-56-6 Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
Catalog No.: AA01JJX4
2252403-56-6,MFCD32062763
2252403-56-6 | Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
Pack Size： 10mg
Purity： 95%
in stock
$598.00 $419.00
Pack Size： 25mg
Purity： 95%
in stock
$1,201.00 $841.00
Pack Size： 100mg
Purity： 95%
in stock
$2,352.00 $1,647.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01JJX4
Chemical Name: Pyrido[2,3-d]pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(1-methylethyl)-3-pyridinyl]-4-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
CAS Number: 2252403-56-6
Molecular Formula: C30H30F2N6O3
Molecular Weight: 560.5944
MDL Number: MFCD32062763
SMILES: C=CC(=O)N1CCN(C(C1)C)c1nc(=O)n(c2c1cc(F)c(n2)c1c(O)cccc1F)c1c(C)ccnc1C(C)C
Properties
Downstream Synthesis Route
126325-50-6   
(1R)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-4-methyl-2-(1-methylethyl)-3-pyridinyl-4-(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinylpyrido2,3-dpyrimidin-2(1H)-one 

[1]Patent:US2018/334454,2018,A1

[2]JournalofMedicinalChemistry,2020,vol.63,p.52-65

1698293-93-4    2252403-56-6 

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[4]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[5]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[6]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[7]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

82671-06-5    2252403-56-6 

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[4]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[5]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[6]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[7]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[8]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[9]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[10]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[11]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[12]CurrentPatentAssignee:AMGENINC-WO2021/97212,2021,A1

[13]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN115466259,2022,A

[14]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2022/246459,2022,A1

113237-20-0    2252403-56-6 

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[4]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[5]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[6]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[7]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[8]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[9]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[10]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[11]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[12]CurrentPatentAssignee:AMGENINC-WO2021/97212,2021,A1

[13]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN115466259,2022,A

[14]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2022/246459,2022,A1

2252403-81-7    2252403-56-6 

[1]CurrentPatentAssignee:AMGENINC-US2018/334454,2018,A1

[2]Lanman,BrianA.;Allen,JenniferR.;Allen,JohnG.;Amegadzie,AlbertK.;Ashton,KateS.;Booker,ShonK.;Chen,JianJeffrey;Chen,Ning;Frohn,MichaelJ.;Goodman,Guy;Kopecky,DavidJ.;Liu,Longbin;Lopez,Patricia;Low,JonathanD.;Ma,Vu;Minatti,AnaE.;Nguyen,ThomasT.;Nishimura,Nobuko;Pickrell,AlexanderJ.;Reed,AnthonyB.;Shin,Youngsook;Siegmund,AaronC.;Tamayo,NuriaA.;Tegley,ChristopherM.;Walton,MaryC.;Wang,Hui-Ling;Wurz,RyanP.;Xue,May;Yang,KevinC.;Achanta,Pragathi;Bartberger,MichaelD.;Canon,Jude;Hollis,L.Steven;McCarter,JohnD.;Mohr,Christopher;Rex,Karen;Saiki,AnneY.;SanMiguel,Tisha;Volak,LaurieP.;Wang,KevinH.;Whittington,DouglasA.;Zech,StephanG.;Lipford,J.Russell;Cee,VictorJ.[JournalofMedicinalChemistry,2020,vol.63,#1,p.52-65]

[3]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[4]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[5]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[6]CurrentPatentAssignee:AMGENINC-WO2020/102730,2020,A1

[7]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[8]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[9]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[10]CurrentPatentAssignee:AMGENINC-WO2020/106647,2020,A2

[11]CurrentPatentAssignee:AMGENINC-WO2021/97207,2021,A1

[12]CurrentPatentAssignee:AMGENINC-WO2021/97212,2021,A1

[13]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN115466259,2022,A

[14]CurrentPatentAssignee:ROCHEHOLDINGAG-WO2022/246459,2022,A1

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