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22594-69-0,MFCD00011528
Catalog No.:AA003PB6

22594-69-0 | Tricarbonyldichlororuthenium(ii) dimer

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100mg
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$32.00   $22.00
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250mg
98%
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$62.00   $43.00
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1g
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$245.00   $171.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003PB6
Chemical Name:
Tricarbonyldichlororuthenium(ii) dimer
CAS Number:
22594-69-0
Molecular Formula:
C6Cl4O6Ru2
Molecular Weight:
512.0126
MDL Number:
MFCD00011528
SMILES:
[O]#C[Ru+2]1([Cl-])(C#[O])(C#[O])[Cl-][Ru+2]([Cl-]1)([Cl-])(C#[O])(C#[O])C#[O]
Properties
Properties
 
Form:
Solid  
MP:
208°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
12.8  
Covalently-Bonded Unit Count:
8  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  

Downstream Synthesis Route
22594-69-0   
KCo*4CO=KCo(CO)4 
 
Co2Ru*11CO=RuCo2(CO)11 

[1]Roland,Eckehart;Vahrenkamp,Heinrich[AngewandteChemie,1981,vol.93,p.714-715]

[1]Behnken,PaulE.;Hawthorne,M.Frederick[InorganicChemistry,1984,vol.23,#21,p.3420-3423]

[1]Haerkoenen,AapoU.;Ahlgren,Markku;Pakkanen,TapaniA.;Pursiainen,Jouni[JournalofOrganometallicChemistry,1999,vol.573,#1-2,p.225-231]

22594-69-0    56625-78-6   
phosphoricacid 
 
Ru2Ir2H(CO)12Cl 

[1]Haerkoenen,AapoU.;Ahlgren,Markku;Pakkanen,TapaniA.;Pursiainen,Jouni[JournalofOrganometallicChemistry,1999,vol.573,#1-2,p.225-231]

Literature

Title: Andrographolide inhibits hypoxia-induced hypoxia-inducible factor 1α and endothelin 1 expression through the heme oxygenase 1/CO/cGMP/MKP-5 pathways in EA.hy926 cells.

Journal: Environmental toxicology 20180301

Title: Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.

Journal: Environmental toxicology 20170301

Title: Carbon monoxide releasing molecule-2 ameliorates IL-1β-induced IL-8 in human gastric cancer cells.

Journal: Toxicology 20160615

Title: Induction of HO-1 by carbon monoxide releasing molecule-2 attenuates thrombin-induced COX-2 expression and hypertrophy in primary human cardiomyocytes.

Journal: Toxicology and applied pharmacology 20151201

Title: Carbon Monoxide (CO) Released from Tricarbonyldichlororuthenium (II) Dimer (CORM-2) in Gastroprotection against Experimental Ethanol-Induced Gastric Damage.

Journal: PloS one 20150101

Title: The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.

Journal: Toxicology and applied pharmacology 20140101

Title: Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway.

Journal: Toxicology and applied pharmacology 20131115

Title: Treatment with carbon monoxide-releasing molecules and an HO-1 inducer enhances the effects and expression of µ-opioid receptors during neuropathic pain.

Journal: Anesthesiology 20130501

Title: Divergent molecular mechanisms underlay CO- and CORM-2-induced relaxation of corpora cavernosa.

Journal: The journal of sexual medicine 20120901

Title: Cell damage following carbon monoxide releasing molecule exposure: implications for therapeutic applications.

Journal: Basic & clinical pharmacology & toxicology 20120701

Title: Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase.

Journal: Circulation research 20120427

Title: Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis.

Journal: Journal of cellular biochemistry 20120201

Title: Therapeutic potential of carbon monoxide in multiple sclerosis.

Journal: Clinical and experimental immunology 20120201

Title: Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation.

Journal: European journal of pharmacology 20120115

Title: Carbon monoxide protects against ischemia-reperfusion injury in vitro via antioxidant properties.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: The carbon monoxide releasing molecule CORM-2 attenuates Pseudomonas aeruginosa biofilm formation.

Journal: PloS one 20120101

Title: Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice.

Journal: PloS one 20120101

Title: Redox-based thrombelastographic method to detect carboxyhemefibrinogen-mediated hypercoagulability.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

Title: Carbon monoxide-releasing molecule-2 enhances coagulation in rabbit plasma and decreases bleeding time in clopidogrel/aspirin-treated rabbits.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

Title: Carbon monoxide and nitric oxide modulate α₂-antiplasmin and plasmin activity: role of heme.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

Title: p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro.

Journal: European journal of pharmacology 20111116

Title: Carbon monoxide releasing molecule-2 improves coagulation in patient plasma in vitro following cardiopulmonary bypass.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110701

Title: Fibrinogen is a heme-associated, carbon monoxide sensing molecule: a preliminary report.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110701

Title: Wound healing activity of carbon monoxide liberated from CO-releasing molecule (CO-RM).

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110701

Title: Beneficial effects of carbon monoxide-releasing molecule-2 (CORM-2) on acute doxorubicin cardiotoxicity in mice: role of oxidative stress and apoptosis.

Journal: Toxicology and applied pharmacology 20110515

Title: Attenuation of transforming growth factor-β-stimulated collagen production in fibroblasts by quercetin-induced heme oxygenase-1.

Journal: American journal of respiratory cell and molecular biology 20110501

Title: Carbon monoxide-releasing molecules protect against ischemia-reperfusion injury during kidney transplantation.

Journal: Kidney international 20110501

Title: Effects of carbon monoxide on ion transport across rat distal colon.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20110201

Title: Carbon monoxide releasing molecule-2 enhances coagulation and attenuates fibrinolysis by two mechanisms: insights gained with colloid dilution.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110101

Title: Control of cell migration and inflammatory mediators production by CORM-2 in osteoarthritic synoviocytes.

Journal: PloS one 20110101

Title: Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages.

Journal: Shock (Augusta, Ga.) 20101201

Title: Carbon monoxide induces cyclooxygenase-2 expression through MAPKs and PKG in phagocytes.

Journal: International immunopharmacology 20101201

Title: Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban.

Journal: Anesthesia and analgesia 20101201

Title: Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells.

Journal: Toxicology and applied pharmacology 20101115

Title: Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in subjects exposed to warfarin.

Journal: Thrombosis research 20100701

Title: Prevention by lansoprazole, a proton pump inhibitor, of indomethacin -induced small intestinal ulceration in rats through induction of heme oxygenase-1.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100601

Title: Carbon monoxide liberated from CO-releasing molecule (CORM-2) attenuates ischemia/reperfusion (I/R)-induced inflammation in the small intestine.

Journal: Inflammation 20100401

Title: Carbon monoxide releasing molecule-2 inhibits pancreatic stellate cell proliferation by activating p38 mitogen-activated protein kinase/heme oxygenase-1 signaling.

Journal: Molecular pharmacology 20100401

Title: Effects of carbon monoxide releasing molecule-liberated CO on severe acute pancreatitis in rats.

Journal: Cytokine 20100101

Title: Cardioprotective effect with carbon monoxide releasing molecule-2 (CORM-2) in isolated perfused rat heart: Role of coronary endothelium and underlying mechanism.

Journal: Vascular pharmacology 20100101

Title: Carbon monoxide-releasing molecule-2 (CORM-2) attenuates acute hepatic ischemia reperfusion injury in rats.

Journal: BMC gastroenterology 20100101

Title: Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.

Journal: Atherosclerosis 20091201

Title: Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages.

Journal: Inflammation 20091201

Title: Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo.

Journal: Molecular pharmacology 20090701

Title: The protective role of HO-1 and its generated products (CO, bilirubin, and Fe) in ethanol-induced human hepatocyte damage.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090601

Title: Carbon monoxide produced by intrasinusoidally located haem-oxygenase-1 regulates the vascular tone in cirrhotic rat liver.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20090501

Title: Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice.

Journal: Cardiovascular research 20090401

Title: Protection of carbon monoxide-releasing molecule against lung injury induced by limb ischemia-reperfusion.

Journal: Chinese journal of traumatology = Zhonghua chuang shang za zhi 20090401

Title: [Inhibitive effect of exogenous carbon monoxide-releasing molecules 2 on tissue factor expression in sepsis].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20090401

Title: Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coli.

Journal: Microbiology (Reading, England) 20090301

Title: Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20081101

Title: The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes.

Journal: Rheumatology (Oxford, England) 20080901

Title: Tricarbonyldichlororuthenium (II) dimer (CORM2) activates non-selective cation current in human endothelial cells independently of carbon monoxide releasing.

Journal: European journal of pharmacology 20080820

Title: Investigation of a possible interaction between the heme oxygenase/biliverdin reductase and nitric oxide synthase pathway in murine gastric fundus and jejunum.

Journal: European journal of pharmacology 20080820

Title: Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20080701

Title: Carbon monoxide-releasing molecule tricarbonyldichlororuthenium (II) dimer induces concentration-dependent alterations in the electrophysiological properties of axons in mammalian spinal cord.

Journal: Neuroscience 20080219

Title: Modulation of hTREK-1 by carbon monoxide.

Journal: Neuroreport 20080212

Title: Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death.

Journal: Free radical biology & medicine 20080201

Title: Carbon monoxide-releasing molecules: a pharmacological expedient to counteract inflammation.

Journal: Current pharmaceutical design 20080101

Title: Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC.

Journal: International journal of biological sciences 20080101

Title: Mechanisms of relaxation by carbon monoxide-releasing molecule-2 in murine gastric fundus and jejunum.

Journal: European journal of pharmacology 20071031

Title: [The inhibitory effects of extrinsic carbon monoxide-releasing molecules II on inflammatory responses in liver of mice with severe burns].

Journal: Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20070601

Title: Attenuation of leukocytes sequestration by carbon monoxide-releasing molecules: liberated carbon monoxide in the liver of thermally injured mice.

Journal: Journal of burn care & research : official publication of the American Burn Association 20070101

Title: CO from enhanced HO activity or from CORM-2 inhibits both O2- and NO production and downregulates HO-1 expression in LPS-stimulated macrophages.

Journal: Biochemical pharmacology 20060112

Title: The inhibitory effects of roflumilast on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells are mediated by heme oxygenase-1 and its product carbon monoxide.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20051201

Title: Carbon monoxide reduces the expression and activity of matrix metalloproteinases 1 and 2 in alveolar epithelial cells.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20050930

Title: Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle.

Journal: The Journal of biological chemistry 20050708

Title: Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages.

Journal: British journal of pharmacology 20050701

Title: Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages.

Journal: Biochemical pharmacology 20050615

Title: Protective effect of carbon monoxide-releasing compounds in ischemia-induced acute renal failure.

Journal: Journal of the American Society of Nephrology : JASN 20050401

Title: The effect of a carbon monoxide-releasing molecule on the immunological activation of guinea-pig mast cells and human basophils.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20040301

Title: Heme oxygenase-1 attenuates interleukin-1beta-induced nitric oxide synthase expression in vascular smooth muscle cells.

Journal: Journal of biomedical science 20040101

Title: Induction of heme oxygenase-1 expression in murine macrophages is essential for the anti-inflammatory effect of low dose 15-deoxy-Delta 12,14-prostaglandin J2.

Journal: The Journal of biological chemistry 20030523

Title: Magierowska K, et, al. Oxidative gastric mucosal damage induced by ischemia/reperfusion and the mechanisms of its prevention by carbon monoxide-releasing tricarbonyldichlororuthenium (II) dimer. Free Radic Biol Med. 2019 Dec; 145:198-208.

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