Home Carboxes 22649-27-0
22649-27-0,MFCD00488345
Catalog No.:AA00CBW0

22649-27-0 | 3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$311.00   $218.00
- +
1g
95%
in stock  
$760.00   $532.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00CBW0
Chemical Name:
3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one
CAS Number:
22649-27-0
Molecular Formula:
C10H7ClO4
Molecular Weight:
226.6132
MDL Number:
MFCD00488345
SMILES:
Oc1cc(O)c2c(c1)oc(=O)c(c2C)Cl
Properties
Properties
 
Form:
Solid  
MP:
306-308℃ (decomp)  

Computed Properties
 
Complexity:
325  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
XLogP3:
2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CHINESEACADEMYOFMEDICALSCIENCES-CN103450134,2017,BLocationinpatent:Paragraph0024;0140;0144

[2]Locationinpatent:experimentalpartAzizian,Javad;Mohammadi,AliA.;Bidar,Ilyar;Mirzaei,Peiman[MonatsheftefurChemie,2008,vol.139,#7,p.805-808]

[3]Mirjalili,BiBiFatemeh;Bamoniri,Abdolhamid;Fazeli-Attar,SeyedeAzita[ResearchonChemicalIntermediates,2022,vol.48,#2,p.839-851]

[4]Rodriguez-Dominguez,JuanC.;Kirsch,Gilbert[Synthesis,2006,#11,p.1895-1897]

[5]Rodríguez-Domínguez,JuanCarlos;Kirsch,Gilbert[TetrahedronLetters,2006,vol.47,#19,p.3279-3281]

[6]Dey[JournaloftheChemicalSociety,1915,vol.107,p.1637]

[7]Chakravarti[JournaloftheIndianChemicalSociety,1931,vol.8,p.407][JournaloftheIndianChemicalSociety,1935,vol.12,p.536,539]

[8]Locationinpatent:experimentalpartLi,Gang;Wang,Dongmei;Sun,Mingna;Li,Guangyan;Hu,Jinfeng;Zhang,Yun;Yuan,Yuhe;Ji,Haijie;Chen,Naihong;Liu,Gang[JournalofMedicinalChemistry,2010,vol.53,#4,p.1741-1754]

Literature

Title: Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice.

Journal: Journal of medicinal chemistry 20100225

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:22649-27-0 Molecular Formula|22649-27-0 MDL|22649-27-0 SMILES|22649-27-0 3-Chloro-5,7-dihydroxy-4-methyl-2h-chromen-2-one