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2265-22-7,MFCD00271760
Catalog No.:AA00BHRF

2265-22-7 | dexamethasone 21-methanesulfonate

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Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
2 weeks  
$374.00   $262.00
- +
100mg
2 weeks  
$939.00   $658.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00BHRF
Chemical Name:
dexamethasone 21-methanesulfonate
CAS Number:
2265-22-7
Molecular Formula:
C23H31FO7S
Molecular Weight:
470.5514
MDL Number:
MFCD00271760
SMILES:
O=C1C=C[C@]2(C(=C1)CCC1[C@]2(F)[C@@H](O)C[C@]2(C1C[C@H]([C@]2(O)C(=O)COS(=O)(=O)C)C)C)C
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1.3  

Literature

Title: Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition.

Journal: Bioorganic & medicinal chemistry letters 20161015

Title: Transferrin-PEG-PE modified dexamethasone conjugated cationic lipid carrier mediated gene delivery system for tumor-targeted transfection.

Journal: International journal of nanomedicine 20120101

Title: The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system.

Journal: Hepatology (Baltimore, Md.) 20081001

Title: Effects of acetylation, polymerase phosphorylation, and DNA unwinding in glucocorticoid receptor transactivation.

Journal: The Journal of steroid biochemistry and molecular biology 20060701

Title: Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

Journal: Biochemistry 20050510

Title: Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes.

Journal: Biochemistry 20050308

Title: Modulation of transcriptional sensitivity of mineralocorticoid and estrogen receptors.

Journal: The Journal of steroid biochemistry and molecular biology 20040801

Title: Interleukin-6 and glucocorticoids synergistically induce human immunodeficiency virus type-1 expression in chronically infected U1 cells by a long terminal repeat independent post-transcriptional mechanism.

Journal: Molecular medicine (Cambridge, Mass.) 20011001

Title: New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties.

Journal: Molecular endocrinology (Baltimore, Md.) 20010201

Title: Role of cysteines 640, 656, and 661 in steroid binding to rat glucocorticoid receptors.

Journal: The Journal of biological chemistry 19920605

Title: Localization of the vicinal dithiols involved in steroid binding to the rat glucocorticoid receptor.

Journal: Endocrinology 19901101

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