Home Other Building Blocks 226878-01-9
226878-01-9,MFCD05865239
Catalog No.:AA00BFZ4

226878-01-9 | NPS 2390

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
5mg
98%
in stock  
$61.00   $43.00
- +
10mg
98%
in stock  
$103.00   $72.00
- +
50mg
98%
in stock  
$240.00   $168.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BFZ4
Chemical Name:
NPS 2390
CAS Number:
226878-01-9
Molecular Formula:
C19H21N3O
Molecular Weight:
307.3895
MDL Number:
MFCD05865239
SMILES:
O=C(c1cnc2c(n1)cccc2)NC12CC3CC(C2)CC(C1)C3
Properties
Computed Properties
 
Complexity:
450  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
4.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-US6429207,2002,B1

Literature

Title: Effect of the calcium sensing receptor on rat bone marrow-derived mesenchymal stem cell proliferation through the ERK1/2 pathway.

Journal: Molecular biology reports 20120701

Title: Involvement of calcium-sensing receptor in oxLDL-induced MMP-2 production in vascular smooth muscle cells via PI3K/Akt pathway.

Journal: Molecular and cellular biochemistry 20120301

Title: Post-conditioning protecting rat cardiomyocytes from apoptosis via attenuating calcium-sensing receptor-induced endo(sarco)plasmic reticulum stress.

Journal: Molecular and cellular biochemistry 20120201

Title: Stimulation of Ca2+-sensing receptor inhibits the basolateral 50-pS K channels in the thick ascending limb of rat kidney.

Journal: Biochimica et biophysica acta 20120201

Title: Pharmacological evidences for the stimulation of calcium-sensing receptors by nifedipine in gingival fibroblasts.

Journal: Journal of pharmacology & pharmacotherapeutics 20110101

Title: Nickel induces intracellular calcium mobilization and pathophysiological responses in human cultured airway epithelial cells.

Journal: Chemico-biological interactions 20100105

Title: The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.

Journal: Reproduction (Cambridge, England) 20090901

Title: Positive and negative modulation of group I metabotropic glutamate receptors.

Journal: Journal of medicinal chemistry 20080214

Title: [3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.

Journal: Molecular pharmacology 20030501

Title: Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

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Tags:226878-01-9 Molecular Formula|226878-01-9 MDL|226878-01-9 SMILES|226878-01-9 NPS 2390