Home Amines 226907-52-4
226907-52-4,MFCD21337856
Catalog No.:AA006WY5

226907-52-4 | 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

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1mg
≥98%
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$415.00   $290.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA006WY5
Chemical Name:
6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
CAS Number:
226907-52-4
Molecular Formula:
C15H17N5O3
Molecular Weight:
315.3272
MDL Number:
MFCD21337856
SMILES:
COCCOc1nc(N)c2c(n1)n(Cc1ccccc1)c(n2)O
Properties
Computed Properties
 
Complexity:
405  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
0.7  

Literature

Title: Mast cell-mediated inhibition of abdominal neutrophil inflammation by a PEGylated TLR7 ligand.

Journal: Mediators of inflammation 20120101

Title: Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system.

Journal: PloS one 20120101

Title: Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.

Journal: Blood 20110526

Title: Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept.

Journal: Journal of medicinal chemistry 20100408

Title: Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates.

Journal: Bioconjugate chemistry 20090617

Title: An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models.

Journal: Cancer gene therapy 20090501

Title: 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Comparison of rat and human responses to toll-like receptor 7 activation.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20090201

Title: Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080701

Title: Synthesis and immunostimulatory activity of 8-substituted amino 9-benzyladenines as potent Toll-like receptor 7 agonists.

Journal: Bioorganic & medicinal chemistry letters 20060901

Title: Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.

Journal: Bioorganic & medicinal chemistry letters 20060615

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Tags:226907-52-4 Molecular Formula|226907-52-4 MDL|226907-52-4 SMILES|226907-52-4 6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol