Catalog No.:AA00BDOG

227619-64-9 | 3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID

Name: Name:3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID
Brand: AABLOCKS
SKU: AA00BDOG
Rating: 90 (10 reviews)

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00BDOG

Chemical Name:

3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-4-CARBOXYLIC ACID

CAS Number:

227619-64-9

Molecular Formula:

C12H16N4O8

Molecular Weight:

344.2774

MDL Number:

MFCD08703102

SMILES:

OC(=O)[C@H]1NC[C@H]2[C@@H]1C(=NO2)O.OC(=O)[C@@H]1NC[C@@H]2[C@H]1C(=NO2)O

Properties

Computed Properties

Complexity:

242

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

XLogP3:

-3.9

Literature

Title: Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reuptake.

Journal: The Journal of pharmacology and experimental therapeutics 20080801

Title: Dissociation of [3H]L-glutamate uptake from L-glutamate-induced [3H]D-aspartate release by 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid and 3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic acid, two conformationally constrained aspartate and glutamate analogs.

Journal: Molecular pharmacology 20040901

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